I am so thankful for this website. This past weekend, as I prepared to begin a hell of 6 days without methadone, I researched w/d help here, and I *finally* found the best way to use to loperamide. I'd used it before, but it never seemed to be to be enough. I was still "sick"...shakes, sweating, you know the drill.
So, now I've been in methadone withdrawal for 4 days, and I've been taking "lope", 20mg in the AM, 20-30mg at night, and it's helped a lot! Very little anxiety, no sickness, very little aches & pains.
There are theories that quinine (it's in tonic water) or cimetidine (an anti-acid) will help the loperamide cross the blood brain barrier...I don't know if that's true, but it's certainly worth a try.
If anyone ever needs help getting through opiate withdrawal, please get some "lope", you will be happy you did, I promise. Also, take a stool softener (or 2) every day with a magnesium citrate supplement, and drink lots of water, that way you will not get constipated. It's all been working wonders for me!