Adolescent Amphetamine Usage Could Impact Short-Term Memory in Adulthood

By chillinwill · Dec 19, 2009 · ·
  1. chillinwill
    Researchers at the University of Illinois have discovered that lab mice given large amounts of amphetamine during adolescence have impaired working (short-term) memory in adulthood. The scientists found that mice given the drugs during adolescence performed activities far more poorly than mice given the same amount of amphetamine as adults.

    The study’s lead investigator, Psychology professor Joshua Gulley, said during the results unveiling at the Society for Neurosciences in Chicago, the results indicate working memory capacity is severely impacted by early exposure to amphetamine. The theory as to why this happens is that the brain is still developing during adolescence and exposure to the harsh drug can lead to long-term consequences in cognitive performance.

    The scientists say that early abuse of amphetamine may also be relevant for children taking the drug to treat Attention Deficit Hyperactivity Disorder.

    December 18, 2009
    Behavioral Health Central

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  1. chillinwill
    High Amphetamine Use in Adolescence Impacts Adult Memory

    It isn’t any real surprise that drugs can have a negative impact on a person – especially with prolonged use. Now, research conducted on rats is finding that high doses of amphetamines at an age that corresponds to the later years of adolescence tends to greatly impact memory in adult life.

    This finding, discussed in Science Daily shows that such an impact on the memory presents itself long after the exposure ends. One interesting finding from this study showed that the memory deficit did not emerge until adulthood. Those in adolescence using the drug still had full memory capacity.

    "Animals that were given the amphetamine during the adolescent time period were worse at tasks requiring working memory than adult animals that were given the same amount of amphetamine as adults," said psychology professor Joshua Gulley, who led the study with graduate student Jessica Stanis. "This tells us that their working memory capacity has been significantly altered by that pre-exposure to amphetamine."

    To conduct this study, researchers tested two types of amphetamine exposure, which included intermittent – or a steady dose every other day – and “binge escalation” in which increasing amounts of the drug were given over a period of four days and then followed by a simulated binge or a high dose every two hours for eight hours on the fifth day.

    This study reveals some of the potential long-term consequences associated with amphetamine abuse by adolescents and could be relevant to those taking amphetamines for therapeutic purposes, including those being treated for Attention Deficit Hyperactivity Disorder (ADHD).

    "Adolescence is a time when the brain is continuing to develop into its mature form, so drug exposure during this critical period could have long-lasting, negative consequences," Gully said. "Our findings reveal that adolescents are particularly sensitive to the adverse effects of amphetamine on cognitive function and that these effects can persist well after drug use is discontinued."

    October 28, 2009
    Drug Addiction Treatment
  2. Nnizzle
    Is there going to be a publication about this? I'd like to see some numbers.
  3. NeuromindeD
    SWIM was prescribed 60mg of Adderall when 14 years old and took this does over the period of 5 years. SWIM for some dumb reason stopped a while back (SWIM's new found love didn't like all the pills). Since then, about three years, SWIM just hasn't been the same. Not happy, very little motivation and of course focus out the window.

    Fed up, a couple weeks ago SWIM tried pressing his GP for a script to begin again and the conversation quickly turns out of his favor. The GP clearly doesn't like the idea and suggest referral to another doc. Not so long ago they were pretty much handing out all the amphetamine based scripts. Today if you ask they look at you like your some junkie.

    SWIM just wants to feel "normal again". So yes, SWIM can contest to this somewhat obvious news.

    Thanks for the post!
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