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  1. Lunar Loops
    This from The Jerusalem Post:

    5 hallucinogens added to dangerous drugs list

    At the HealthMinistry's request, five dangerous substances sold in kiosks and 24-hour shops were added to the list of "dangerous drugs" by the Knesset Labor, Social Affairs and Health Committee on Monday.

    The addictive "mind-benders," which previously were illegal to sell but were not on the ministry's list of restricted imports, are called Halahit shel Ilanit (Ilanit's Hit); Halom Belavan (White Dream); Rakefet (Cyclamen); Aspirin Im Kritza (Aspirin With a Wink); and Hagigat Kayitz 2008 (Celebration of the Summer of 2008).

    According to the Knesset committee, they come in capsule, pill and liquid form and cause serious and uncontrollable side effects. They also cause harm to internal organs, including the brain, heart, liver and kidneys. The main consumers of these drugs are teenagers.

    Five percent of all drug abuse files opened during the past year involved this type of drug, according to Dep.-Cmdr. Udi Wolf of the Internal Security Ministry. Only this past week, he said, 12,000 capsules were seized, each costing NIS 80 to NIS 120. Until now, those guilty of possession could get up to three years in jail, but now that they are on the serious drugs list, they can get up to 20 years in prison.

    These capsules replace the well-known hagigat, which was previously made illegal, and now they have various street names. "Drug dealers have become increasingly sophisticated and clever" in their aim of selling drugs, committee chairman MK Yitzhak Galanti (Gil Pensioners) said. "This requires the legal authorities to become more alert in identifying new drug compounds. I have no doubt that as we add more to the list, new ones will appear."

Comments

  1. grandbaby
    Re: 5 hallucinogens added to dangerous drugs list

    Hm. Anyone have any idea what's in these ... interestingly ... named products?
  2. enquirewithin
    Re: 5 hallucinogens added to dangerous drugs list

    I suspect these are related to Neo-Doves, Sub-Coca, etc. Perhaps cathinone derivatives like hagigat?
  3. rxbandit
    Re: 5 hallucinogens added to dangerous drugs list

    hmm, as we ban more drugs, more dangerous ones replace them, to ensure public health we must illegalize these new drugs... it sounds as if prohibition is causing more harm potential as the market discovers less tried and true inebriants due to irresponsible legislation.
  4. Nacumen
    Re: 5 hallucinogens added to dangerous drugs list

    SWIM met a former dealer who recently lived in Jerusalem - and he didn't mention anything like this.

    Hallucinogenic? Addictive? Dangerous to the internal organs?

    Nothing that I know of would fit that profile.
  5. Alfa
    Re: 5 hallucinogens added to dangerous drugs list

    I expect so as well.
  6. MrG
    Re: Israel: 5 new drugs added to dangerous drugs list

    Related, probably, but how related. And where is the research to back up the government's claim of how harmful they are?

    They don't say what's in them so what's with the "cause serious and uncontrollable side effects. They also cause harm to internal organs, including the brain, heart, liver and kidneys" reference?

    If there has been any published research on these substances then the government would have referenced it in order to prove their stance. So it sounds as if it is simply scaremongering.
  7. enquirewithin
    Re: Israel: 5 new drugs added to dangerous drugs list

    To most governments, the fact that something is significantly psychoactive is enough to make them ban it. "...serious and uncontrollable side effects"-- such as having fun!
  8. MrG
    Re: Israel: 5 new drugs added to dangerous drugs list

    LOL - Exactly. What is that statement even supposed to mean?

    "serious and uncontrollable" - meaningless nonsense. Look, I don't know if these substances are harmful or not, we don't what the hell they are for starters, but the whole "its drugs so it must be harmful" approach is just lazy. Do the research, present the substansive proof and then you have every right to ban them if they are actually very dangerous.
  9. Systemdoll
    Chemical analysis of Neorganics Products

    Chemical Analysis of Neorg. Products

    The following results stem from analysing 4 x samples, as received by the analytical chemists involved. Before discussing these results, a few points need to be mentioned.

    The analytical procedures were carried out by experienced, qualified forensic chemists working in a NATA accredited laboratory. This is not a police department laboratory, but an independently run lab, the type which is contracted by agencies such as police and other investigative bodies.

    These results are representative of the above mentioned samples. It's possible that the manufacturer/ supplier may have changed the formulae of these products since the time these samples were received. The products could also be packaged differently or may now contain different formulations. Variation in formulae may include:
    • Addition of other compounds not found in tested samples
    • Removal or replacement of one or more active compounds
    • Reformulation of the determined compounds i.e. altered ratios of active compounds.
    Procedures:

    Analyses were accomplished using Gas Chromatography & Mass Spectral Detection (GC/MSD) for volatile and semi volatile organic compounds and Liquid chromatography and Mass Spectral Detection (LC/MSD) to determine molecular weight. Nuclear Magnetic resonance was used to elucidate the structure of one chemical, for which spectral data was unavailable.


    Limitations:

    As pure certified reference samples of the suspected compounds were not available, identification using GC/MSD can only be considered tentative. Interpretation of results from the above mentioned procedures has been independently assessed and conclusions validated.


    Notification of Authorities:

    Due to the illicit nature of 4 of the five compounds identified, authorities were informed of the outcomes of these tests. As far as I understand from the lab report, the products were identified solely by their appearance, and labeled from ‘xxxxxxx-1’ to ‘xxxxxxx-4’ (where ‘xxxxxxx-x’ is a case number or batch code). As the products were not sourced by the analysts, company and product names were not known, and so not stated on the official report.


    Results:

    Product xxxxxxx-1

    [​IMG]

    Procedures used: Marquis presumptive test, GC/MSD, LC/MSD, NMR,

    Reaction with Marquis Reagent produced a pale pink colour. Interpretation of spectral data indicated the presence of:

    4-Methylmethcathinone


    Structural description: 4-methylmethcathinone is a para-substituted, N-methyl cathinone.


    Product xxxxxxx-2


    [​IMG]

    Procedures used: Marquis presumptive test, GC/MSD, LC/MSD

    Reaction with Marquis Reagent was considered relatively insignificant and produced a slightly yellow colour. Interpretation of spectral data indicated the presence of:

    4-Fluoromethamphetamine

    Structural description: 4-fluoromethamphetamine is a para-substituted, N-methylamphetamine

    Phthalimidopropiophenone

    Structural description:
    Phthalimidopropiophenone is a phthalimido derivative of cathinone.


    Products xxxxxxx-3

    [​IMG]

    &

    Product xxxxxxx-4

    [​IMG]


    Procedures used: Marquis presumptive test, GC/MSD, LC/MSD

    It was concluded that products xxxxxxx-3 & xxxxxxx-4 contain the same active compounds, but in different proportions (quantitative data not provided).

    Reaction with Marquis produced a pale orange colour, dissimilar to the colour produced from Marquis Reagent reaction with amphetamine. Results of spectral data indicate the presence of:


    4-Methylmethcathinone (N-methyl-4-methylaminopropiophenone)

    Metamfepramone

    Phthalimidopropiophenone

    Caffeine



    Comments


    There exists little to no pharmacological data for many of these compounds. Where possible some comparisons have been made with similarly structured compounds. It needs to be emphasised though, that in such cases, the following comments are only speculative. However, while the toxicicological profiles for some of these chemicals are still in doubt, it is still worth carefully considering whether, in some cases, there is significant potential for impact on user health and wellbeing. Hopefully, other contributers will be able to further enlighten us on the pharmacology of these compounds.

    Compound:

    4-methylmethcathinone

    [​IMG]

    <IMG style="WIDTH: 480px; ; WIDTH: expression(this.width > 640 ? 480 : true)" alt="" src="http://i254.photobucket.com/albums/hh112/p_d_b_l/image-1.gif" border=0>

    Legal:
    Under Australian law, in most states 4-Methylmethcathinone can be considered an analogue of the scheduled (illicit) drug methcathinone.

    Pharmacological: 4-Methylmethcathinone is sympathomimetic stimulant. From proposed SAR modelling, 4-methylmethcathinone is expected to have similar pharmacological properties to methcathinone, but with increased activity on the serotonin neurotransmitter systems. Methcathinone is suggested as being more potent than its parent cathinone, and methamphetamine (1)

    Methcathinone is a drug with a high abuse potential, with prolonged, high dosages known to cause psychosis and withdrawal tremors. Methcathinone is regarded as being similar in profile to methamphetamine in relation to neurotoxicity, with marked decreases in DA levels noted among abstinent users. While generally below levels associated with Parkinsons Disease, this is considered to be demonstrative of permanent, or semi permanent neurological damage (2)

    Quote:
    Compared with controls, abstinent methamphetamine
    and methcathinone users had significant decreases in
    DAT density in the caudate nucleus (223 and 224%, respectively)
    and putamen (225 and 216%, respectively).


    It can be speculated that the para substituted compound 4-methylmethcathinone may have reduced stimulant activity, but as said, its likely to have additional affect on serotonin via both monoamine reuptake/ SERT inhibition and direct agonist affects of the 5HT2b receptors. Concerns have been raised regarding the actions of 4-methylmethcathinone in relation to peripheral 5HT (serotonin) stimulation and how that, combined with other catecholamine activity, may be dangerous to the heart.

    In a similar manner to which pulmonary hypertension is caused by peripheral 5HT produced by gastrointestinal carcinoid tumours (and some argue 5HTP), other 5HT2b agonists have been found to cause this effect, which would be exacerbated by increased DA/NE levels and their corresponding affect on the heart. Longer term, such stimulation has been shown to result in fibroblast mitosis of the mitral valve of the left atrium (specifically the Chordae Tendineae). (3,4)

    While it has yet to be demonstrated by means of scientific study that 4-methylmethcathinone produces these effects, I believe it's wise to consider carefully the possible toxicity of this compound if you're intending to ingest or otherwise consume products containing this drug.


    Compound:


    4-Fluormethamphetamine

    [​IMG] <IMG style="WIDTH: 480px; ; WIDTH: expression(this.width > 640 ? 480 : true)" alt="" src="http://i254.photobucket.com/albums/hh112/p_d_b_l/image-2.gif" border=0>

    Legal:
    Under Australian law, in most states 4-Fluoromethamphetamine can be considered an analogue of the scheduled (illicit) drug Methamphetamine.

    Pharmacological: From what I can gather, this compound has not been widely researched. However, the parent compound 4-fluoroamphetamine has been evaluated and compared to other halo amphetamines. While the 4-bromo and 4-chloro amphetamines significantly affect serotonin levels, 4-fluoramphetamine has been found to have minimal effect on 5HT, and contrary to the other halogens, levels are restored within days of use.

    Some concern has been raised regarding potential pulmonary toxicity of the N-methyl analogue, if this compound is a 5HT2b agonist. N-methyl-4-fluoroamphetamine may also have a significantly different neurotoxicity profile than the parent compound (as per methamphetamine when compared to amphetamine) and if meth is anything to go by, will possibly also have increased actions on the 5HT system.

    N-methyl-4-fluoroamphetamine has been noted in Forensic literature (5)


    Compound:

    Metamfepramone



    Legal: Under Australian law, in most states Metamfepramone can be considered an analogue of the scheduled (illicit) drug Methcathinone

    Pharmacological: It has been reported (thanks f&b) that Metamfepramone was once used clinically as an anoretic, although use was ceased due to the abuse potential being higher than with diethylpropion, the N-ethyl homologue, also known as Tenuate Dospan. While Tenuate is less euphoric than Metamfepramone, it too was removed from prescription in Australia and NZ around the early 1980’s for similar reasons.

    Both Metamfepramone and Tenuate are thought to metabolise in a similar manner.

    Quote:
    METHYLEPHEDRINE FINDINGS AFTER INTAKE OF METAMFEPRAMONE - STUDIES ON THE METABOLISM AND THE TOXICOLOGICAL DETECTION OF METAMFEPRAMONE USING GC-MS

    Thomas Kraemer, Negar Makkinejad, and Hans H. Maurer

    Institute of Pharmacology and Toxicology, Department of Toxicology, University of Saarland, D-66421 Homburg (Saar), Germany


    Methylephedrine (ME), a sympathomimetic amine, is ingredient of many over-the-counter cold medications. ME abuse has been reported in some asian countries. Kunsman et al. reported ME findings in drug testing samples in the U.S.A. (1). In our lab, ME was found in urine of patients denying its intake. The only known medication was metamfepramone (R,S-2-dimethylaminopropiophenone, MP), a sympathomimetic used as antihypotonic or as cold medication. To study, whether and how long ME, methylpseudoephedrine, ephedrine (EP) and/or pseudoephedrine (PE) can be detected in urine after intake of MP, we reinvestigated the metabolism of MP, its detection within our STA procedure and the duration of detectability.
    The metabolites were identified in urine after cleavage of conjugates, extraction and derivatization by acetylation using GC-MS. Besides the parent compound, the following metabolites could be identified in urine: ME, EP, PE, nor-EP, nor-MP, hydroxy-nor-MP and hydroxy-nor-EP. Differentiation of the ME and EP diastereomers was achieved after trifluoroacetylation. Three partly overlapping metabolic pathways could be postulated: 1) reduction of the ketogroup, 2) one- and two-fold N-demethylation and 3) ring hydroxylation.
    After intake of 20 mg of MP, its main metabolite ME could be detected for about 140 h, EP and PE for about 132 h (n = 3). Nor-MP, the MP specific metabolite could only be detected for about 52 h. Therefore, in the time window from 52 to 140 h differentiation of MP intake from ME, EP and/or PE use was not possible. The analytical recoveries were 55 % for MP, 98 % for ME and 75 % for PE and the LOD's were 50 ng/mL for MP and 10 ng/mL for ME, EP and PE.
    1. G.W. Kunsman, R. Jones, B. Levine and M.L. Smith; Methylephedrine Concentrations in Blood and Urine Specimens, Abstracts to the SOFT annual meeting, October 5-9, 1997, Utah
    From here


    Quote:
    Diethylpropion [Tenuate Dospan]

    Disposition in the Body.

    Readily absorbed after oral administration. Metabolised by N-dealkylation, reduction, deamination, and N-hydroxylation primarily to active metabolites; keto reduction is stereoselective resulting in the formation of threo–hydroxylated metabolites; glucuronide formation also occurs along with the formation of hippuric and mandelic acids. About 80 to 90% of a dose is excreted in the urine; the amount excreted in the urine is reduced when the urine is alkaline; of the urinary excreted material, N-ethylaminopropiophenone, norephedrine (phenylpropanolamine), and hippuric acid are the main metabolites together with small amounts of unchanged drug, aminopropiophenone, N-diethylnorephedrine, and N-ethylnorephedrine. Diethylpropion crosses the blood–brain barrier and the placenta. The drug and its metabolites are distributed into breast milk.

    Therapeutic concentration

    Following a single oral dose of 75 mg to 5 subjects, a mean peak plasma concentration of 0.007 mg/L was attained in 0.5 h; total concentrations of the monodesethyl and didesethyl metabolites reached an average peak of 0.19 mg/L at 2 h. [G. J. Wright et al.,Drug Metab. Rev.,1975, 4, 267–276.]

    Toxicity.

    The estimated minimum lethal doses are 200 mg for a child and 2 g for an adult.

    The following disposition was reported in a case of fatal overdose resulting from the injection of illicit diethylpropion tablets: blood 5.4 mg/L, bile 14.4 mg/L, kidney 0.9 μg/g, liver 0.9 μg/g, injection site 43.2 μg/g. [R. R. Fysh and J. F. Taylor,Bull. Int. Assoc. Forensic Toxicol.,1978, 142, 16–17.]
    Half–life.

    Derived from urinary excretion data, 1.5 to 3 h in subjects whose urines are acidic.

    From Clarke’s Analysis of Drugs and Poisons



    Compound:

    Phthalimidopropiophenone



    Legal: Under Australian law, if Phthalimidopropiophenone produces an illict drug in-vivo, this compound is considered a pro-drug and as such covered by analogue legislation as applies to most states.

    Chemistry: A known method of producing amines (including beta-keto amines) is to react an alkyl halide with potassium phthalimide (which is itself made from phthalic anhydride and ammonia). The reaction is known as the Gabriel Synthesis of primary amines. Normally, then phthalimido compound is subjected to either acid or alkali hydrolysis to cleave off the phthalate ion and release the amine either as a salt (acid) or a free base (alkali, hydrazine).

    One thing I’ve not mentioned so far concerns the shelf life of cathinones. Cathinones with a secondary or tertiary amine are far more stable than is cathinone itself, which has been noted to sometimes form a cyclization product when being synthesized, and age to form a dimer like product when left standing.

    Cleaving the phthalimido group in the lab therefore not only results in a product with a short shelf life, but is also known for producing side reaction products. In short, it’s messy, with the best method considered to be to use hydrazine, and hydrazine is not nice to work with. Also, by leaving the group attached, the free amine is essentially ‘hidden’, and so its thought this would help to mask an already illicit substance.

    Pharmacological: A range of prodrugs incorporating a GABA-phthalimide structure have been developed, in particular, for applications in the treatment of epilepsy. One question is; can the phthalimido group be adequately cleaved in the stomach? Acid hydrolysis is normally a very slow process, but it’s been suggested that this may be hastened via enzymatic activity or be performed completely by pyramidinases enzymes (thanks vecktor). Concerns to health include the metabolic elimination of the phthalate ion/ phthalic acid, particularly with prolonged use, and the possible impacts if cleavage occurs in sensitive organs. If hydrolysis does occur in the stomach, then it might explain how effects differ with different routes of administration. Either way, it’s expected the rate at which cleavage occurs would be slow, and may explain the noted changing of effects over several hours.


    Compound:

    Caffeine



    Legal: Legal under Australian law


    There's much information available on the effect of caffeine. Caffeine is known to have effect on the absorption of some drugs and drug combinations (6).


    ~~~~~~~~~~~~~~~~~

    Much has not been covered in this post. We have not considered isomers of these compounds and their variations in effects, impurities from synthesis, possibility of interactions with other drugs, etc.....




    Refs

    1) Martin D Schechter; Drug-Drug Discrimination: Stimulus Properties of Drugs of Abuse Upon a Serotonergic-Dopaminergic Continuum; Pharmacology Biochemistry and Behavior Volume 56, Issue 1, January 1997, Pages 89-96

    2) Una D. McCann, Dean F. Wong, Fuji Yokoi, Victor Villemagne, Robert F. Dannals, and George A. Ricaurte; Reduced Striatal Dopamine Transporter Density in Abstinent Methamphetamine and Methcathinone Users: Evidence from Positron Emission Tomography Studies with [11C]WIN-35,428; The Journal of Neuroscience, October 15, 1998, 1 20):8417–8422

    3) Takafumi Nagatomo, Mamunur Rashid, Habib Abul Muntasir and Tadazumi Komiyama; Functions of 5-HT2A receptor and its antagonists in the cardiovascular system; Pharmacology & Therapeutics Volume 104, Issue 1, October 2004, Pages 59-81

    4)- removed- link to other forum

    5) Peter Ro¨sner, Bernd Quednow, Ulrich Girreser, Thomas Junge; Isomeric Fluoro-methoxy-phenylalkylamines: a new series of controlled-substance analogues (designer drugs); Forensic Science International 148 (2005) 143–156

    6) Removed- link to other forum.
    ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ ~~~~

    Comments, criticisms etc on the above are most encouraged.


    I would like to extend a big thanks to the numerous Bluelighters and Non-Blers who assisted with this project. Without the parts you've all played, it simply wouldn't have happened.

    With this report, HR Australia sends a simple message to all manufacturers and suppliers of psychoactive products; List the ingredients of your products.

    I would like to think these outcomes will provide a convincing argument towards providing an analytical service that can evaluate, scrutinize and validate all such products, ranging from health to pharmaceuticals to everything that lies in between.
  10. trptamene
    Re: Chemical analysis of Neorg. Products

    Good stuff, tho not sure about the forum link

    You state
    But I see no type of quantitative data to indicate current ratios...or more importantly actual amounts of each compound.

    Do you know if any type of quantitative analysis was done? Or am I just not seeing it?
  11. Alfa
    Re: Chemical analysis of Neorg. Products

    I wonder if this had such a quick effect already:
    Israel: 5 new drugs added to dangerous drugs list

    Either way; we will soon hear of bans of these compounds. As much as I dislike the way these products are marketed, the people responsible for this analysis are directly responsible for the bans of these compounds in any country where authorities where alerted as a result of this.

    Note:
    white = SC2 = 4-Fluoromethamphetamine with Phthalimidopropiophenone
    yellow = spirit = 4-methylmethcathinone
    blue = subcoca = Metamfepramone + 4-methylmethcathinone + Phthalimidopropiophenone + cafeine
    neo dove = green =Metamfepramone + 4-methylmethcathinone + Phthalimidopropiophenone + cafeine
  12. Alfa
  13. MrG
    Re: Israel: 5 new drugs added to dangerous drugs list

    Now we're talking, proper information at last!
  14. MrG
    Re: Chemical analysis of Neorganics Products

    Be aware that this company changed the colouring on a couple of their products since this test was done.

    The Green and Cream coloured product (ND) was changed on the 8th September 2007 to a single dark blue colour.

    The Light Blue and White product (subcoca) changed to single white colour on the same date.


    Interesting to note that these two products have the same content but different ratios.


    Anyway, this is going to make for some interesting reading and I imagine the following imminent wave of connected postings concerning this report net-wide should at least allow us to get a more accurate insight into the physiological aspects. Something that has been wanted for some time now.

    Just hope it isn't bad news.:(
  15. enquirewithin
    Re: Israel: 5 new drugs added to dangerous drugs list

    Interesting-- as expected, cathinone derivatives and one 'speedy' one--- 4-Fluoromethamphetamine.
  16. Zaprenz
    Re: Chemical analysis of Neorganics Products

    A(nother) good reason not to import products where the ingredients are unknown. Especially considering what occured with RC raids.

    In the UK:

    4-Fluoromethamphetamine
    Surely covered by the PEA catch all clause [?] 4-fluoro-amp was, so cant imagine the methyl variant not being.

    Phthalimidopropiophenone
    Depending on the synth & properties might mean %cathinone content in sample [?] Also the UK has no analogue law but doesn't the PEA catch all mention salt there of etc, this compound could definately be a potential problem in some legal way.

    Metamfepramone, 4-methylmethcathinone
    Probably ok ? Although synth technique ?
  17. MrG
    Re: Chemical analysis of Neorganics Products

    Found this statement from Neorganics on another board. Seems that they are claiming the analysis isn't 100% correct.

    Dear Neorganics Customer.

    The fact that our range of products became very popular made some authorities and some private organizations to put a research into it. And lately They made a lot of progress in discovering what’s in them.
    This is something that we expected because it happened to us 3 times before with other products that we had to stop selling cause they were banned due to their popularity.
    With the current range we work for 3 years.

    So it seems that in the near future all our line of products will be banned first in Israel and after a few months worldwide.
    It’s not going to happen tomorrow. Cause the law says that in order to ban a substance they have to first put it on a "published notification list" for at least 31 days and only than it will be banned. So people could make them selves ready for it.

    They didn’t publish it yet so it means that we have more than 31 days to keep selling this range.
    We really don’t know how much time it’s going to take we will give a 1 month notification when the act will be published. Meaning we will notify with another email to say that we stop selling this range with in 1 month.

    At the time that this range will be banned we will release a new range of products that we think are in much higher quality. I hope that you will like them as much as you liked this range.

    p.s. about the reports published in Bluelight this is what we have to say:
    Some of the substances mentioned are true. But most of them are not true.
    There is no meth related or any meth analogue in our products.
    Our products are safe to use and never caused anyone no harm.

    Whilst the impartiality of the supplier is obviously questionable, one does have to wonder the same about those behind the testing when they make statements like this:


    We have been somewhat coy about the details of where the lab is as much as to protect the investigators as anyone.


    I'm sorry but, as much as I applaud those who arranged the analysis under the guise of harm reduction I feel that, in being as evasive as the manufacturer when it comes to detailing those involved in its lab testing, it would appear that they may be trying to hide a conflict of interest on their side as well.


    There would be absolutely no need to withhold the details of the laboratory unless they felt that, in doing so, it may compromise the claimed impartiality of the results.
  18. Alfa
    Re: Chemical analysis of Neorganics Products


    Great work guys. Until now either greedy vendors, irresponsible consumers and overzealous governments where responsible for research chemicals getting banned. Now you can add certain members of BL to this.



    Analysis of exotic compounds like these are difficult to say the least. Often such analyses are simply not correct, or only come close to the real substances.
    How do you reference the analysis data, when there is no reference data on a compound? This is often the case with new research chemicals.


    Very true. MrG. Also; I can understand that they analysed neorganics products, from a harm reduction perspective, but what is the motivation of the investigators to alert various governments and send the result to those governments?

    They must have known these research chemicals would get banned in the countries they send the lab reports to.
    This surely reeks of alternative motives. Who are these investigators? What lab was used? Where is the original report?
  19. phase
    Re: Israel: 5 new drugs added to dangerous drugs list

    Being the author of the BL post mentioned in the above thread, I can say with some confidence that the Israeli government has been intending to crack down on the company's current range of products for some time. This was confirmed in a chat between a user and the company rep, which was passed on to me.

    Also, Hagigat has been looked into in some detail, with a published artilce on reports to the Israel Poison Information Center. In this article (ref & abstract below) it's mentioned that one casualty required neurosurgical intervention for intracerebral hemorrhage.


    One of the ingredients in the range of products in question is considered a prodrug (phthalimidocathinone), which, it is thought will produce cathinone in-vivo. Methcathinone, the metabolic product of another ingredient, metamfepramone (dimethylcathinone), has also been fairly widely researched.


    In conclusion, I do not believe the analysis of these products has had any appreciable affect on already planned changes to Israeli legislation.
  20. Alfa
    Re: Israel: 5 new drugs added to dangerous drugs list

    Please explain which governments where alerted and why.
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