I've had this floating around in his head for a while. I doesn't know shit about biology or neurochem - so this is about as realistic as a unicorn.
Disclaimer up front: Yes - there are plenty of steps a user can take to avoid post-MDMA depression. That's not the point here.
Lots of people have experienced long(er)-term depression after using MDMA. This is anecdotal, but prevalent enough to say is a fairly common thing. 4-6 hours of fun burns out those little receptors and the body spends the next few days (weeks) replenishing and coming back to normal - during which the seratonin balance is effed and the people feel generally down in the dumps and blue. SWIM's friends call the effect "Bluesdays" - cause the blues last till Tuesday.
Is the door a two-way street? Could a substance be made that so completely depresses a person for a short intense time, that the lingering after-effect is a low-level bliss?
Obviously, if it was possible, the person taking it would need constant monitoring. Vigilant and rigorous shelter from any kinds of potential venues for physical harm. And yes, the journey in those dark hours would be excruciating (though there's plenty of anecdotal evidence suggesting that negative self-examination is cathartic...but that's another topic).
But does the body/brain work that way. If a short, intense bliss experience equates to prolonged low-level doldrums - can a harrowing, brief bout of abject depression result in an extended period of elevated mood?
And you know....I've also often wondered...there are all sorts of viruses. Right?
But they ALL make the host feel bad.
Knowing what little I know - organisms in general tend to have more success proliferating their genetic code through pleasure.
Has anyone ever done research to see if there are viruses out there that make us happy as a result of infection? You know...there are those perpetually stoked folks. They have a seeming aura of sunshine. Gravity weighs them down less. You know someone like this. maybe they're just infected with a virus that no one has ever bothered to look for.