1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
    PLEASE HELP
  1. Calliope
    Viewed from a great height as we scurry about, it can be hard to tell the difference between human and ant societies. We both live in highly organised communities surrounded by architectural structures where each individual has a well-defined role.

    However, Brian Entler and colleagues, from The University of Scranton, USA, wondered whether we may also share a darker side to our characters. The team explains that some insects are capable of forming addictions if the drug is delivered simultaneously with food, teaching us essential lessons about the neurobiology of addiction. However, humans have the ability to become addicted to drugs that provide pleasure alone, and no other species seem to be able to develop such an addiction without the added temptation of food. Knowing that ants are keen to scurry around searching for titbits even if their escapades are unsuccessful, Entler, John Cannon and Marc Seid wondered whether the highly motivated insects could get hooked on a life of self-administered drug dependency.

    Tempting Florida carpenter ants to visit a feeder full of tasty sugar solution, Entler gradually removed the sugar while simultaneously increasing the concentration of highly addictive morphine over a 6-day period in a bid to get them hooked. Initially, the ants lost interest in the feeders as the sugar concentration declined; however, once the insects were completely weaned off the sugar and only the morphine remained, the ants’ interest in the feeder was rekindled. And when Entler offered the ants a choice of snacks – a feeder full of tasty sugar solution versus another containing the drug – their preferences were abundantly clear as they headed for the morphine-laced feeder to feed their habit despite the lack of nutrition. However, when Entler offered ants that had never touched the drug the same option, they clearly sought out the sweet treat. The ants were certainly attracted to morphine, but were they getting the reward-seeking ‘high’ of true junkies or did they just prefer the taste of morphine water?

    To answer the question, Entler analysed the ants’ brains to find out whether they were producing any of the tell-tale neurotransmitters that indicate addiction, and found that the morphine-fed ants had higher levels of dopamine, which directs reward-seeking behaviour: the ants were true junkies. ‘This study establishes ants as the first non-mammalian model of self-administration that is truly analogous to mammals’, says the team, who are keen to begin untangling the basic neural circuits that drive drug addiction in ants and probably humans.

    by Kathryn Knight
    INSIDE JEB Journal of Experimental Biology 2016 219
    Image: Calliope
    http://jeb.biologists.org/content/219/18/2776


    For those who are interested, the full research article is now in the DF archive:
    Brian V. Entler, J. Timothy Cannon, and Marc A. Seid. Morphine addiction in ants: a new model for self-administration and neurochemical analysis (2016) Journal of Experimental Biology 219, 2865-2869 doi:10.1242/jeb.140616
    ABSTRACT
    Conventional definitions of drug addiction are focused on characterizing the neurophysiological and behavioral responses of mammals. Although mammalian models have been invaluable in studying specific and complex aspects of addiction, invertebrate systems have proven advantageous in investigating how drugs of abuse corrupt the most basic motivational and neurochemical systems. It has recently been shown that invertebrates and mammals have remarkable similarities in their behavioral and neurochemical responses to drugs of abuse. However, until now only mammals have demonstrated drug seeking and self administration without the concurrent presence of a natural reward, e.g. sucrose. Using a sucrose-fading paradigm, followed by a two dish choice test, we establish ants as an invertebrate model of opioid addiction. The ant species Camponotus floridanus actively seeks and self-administers morphine even in the absence of caloric value or additional natural reward. Using HPLC equipped with electrochemical detection, the neurochemicals serotonin, octopamine and dopamine were identified and subsequently quantified, establishing the concurrent neurochemical response to the opioid morphine within the invertebrate brain. With this study, we demonstrate dopamine to be governing opioid addiction in the brains of ants. Thus, this study establishes ants as the first non-mammalian model of self administration that is truly analogous to mammals.

Comments

To make a comment simply sign up and become a member!