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  1. Emilita
    [​IMG]Scientists might have found a drug to stop all neuro-degenerative brain diseases, including dementia.

    Dementia isn’t a specific disease but a syndrome. Dementia describes a group of symptoms affecting memory, thinking and social abilities severely enough to interfere with daily functioning. Though dementia generally involves memory loss, memory loss has different causes. So memory loss alone doesn’t lead to dementia.

    Alzheimer’s disease, vascular dementia, multiple sclerosis, Huntington’s disease, and Parkinson’s disease are a few different types of dementia.

    The number of Americans living with Alzheimer’s disease is growing — and growing fast. An estimated 5.5 million Americans of all ages have Alzheimer’s disease. Of the estimated 5.5 million Americans living with Alzheimer’s dementia in 2017, an estimated 5.3 million are age 65 and older and approximately 200,000 individuals are under age 65 and have younger-onset Alzheimer’s.

    One in 10 people age 65 and older (10 percent) has Alzheimer’s dementia. Almost two-thirds of Americans with Alzheimer’s are women. African-Americans are about twice as likely to have Alzheimer’s or other dementia as older whites. Hispanics are about one and one-half times as likely to have Alzheimer’s or other dementia as older whites.

    Because the United States has a growing population of people older than 65 years of age, the incidence of Alzheimer’s and other types of dementias is also increasing and has been projected to keep on increasing in the years to come. According to statistics, every 66 seconds, someone falls into the clasp of some form of dementia. By mid-century, this rate will increase further to every 33 seconds.

    Alzheimer’s disease is the sixth-leading cause of death in the United States. It is the fifth-leading cause of death among those age 65 and older and a leading cause of disability and poor health. As the population of the United States ages, Alzheimer’s is becoming a more common cause of death. It is the only top 10 causes of death that cannot be prevented, cured or even slowed.

    Although deaths from other major causes have decreased significantly, official records indicate that deaths from Alzheimer’s disease have increased significantly. Between 2000 and 2014, deaths from Alzheimer’s disease as recorded on death certificates increased 89 percent, while deaths from heart disease, the number one cause of death, decreased 14 percent. Among people age 70, 61 percent of those with Alzheimer’s are expected to die before the age of 80 compared with 30 percent of people without Alzheimer’s — a rate twice as high.

    A team of the Medical Research Council in the UK in 2013 made headlines around the world when they found out how to stop brain cells from dying in an animal for the first time. This could mean hope for patients suffering from neurodegenerative brain diseases. But the compound used was unsuitable for people, as it caused organ damage.

    More recently, two new drugs have been found that should have the same protective effect on the brain and are already safely used in people. Since 2013, almost 1000 already existing drugs were tested on worms, mice, and human cells. Two of these drugs were found to have stopped brain cells from dying. One of these drugs is already being used by patients suffering from depression. The other is being tested in cancer patients. The drug already being used for depression, called trazodone, was found out to be more effective of the two.

    Prof. Giovanna Mallucci, a researcher for the Medical Research Council’s Toxicology Unit in Leicester, who is also involved in this research, said, “both [drugs] were very highly protective and prevented memory deficits, paralysis, and dysfunction of brain cells.” She also stated that this new development is “really exciting”. She wants to start human clinical trials on dementia patients soon in order to know whether the drugs work.

    “We’re very unlikely to cure them completely, but if you arrest the progression you change Alzheimer's disease into something completely different so it becomes liveable with,” said Prof. Mallucci.

    Image credit: Unknown
    *This article was found by another members, l am posting on their behalf

    Original Source

    Written by: Mike Hardy, Apr 21, 2017, Brain “Wonder-drug” Might be a Cure for Dementia, Facts Chronical
    JaneGault likes this.

Recent User Reviews

  1. mess clean
    4/5, 4 out of 5, reviewed May 3, 2017
    Good article regarding a very specific and horrible set of diseases.

    I use trazodone for sleep. It's amazing to see that it is potentially effective in stopping brain cell death. I'm considering changing my dosage schedule from 150 mg at night to 3x 50 mg throughout the day.

    Great contribution.


  1. profesor
    I took Trazadone for a while. It's very sedating. Psychiatrists often prescribe it for insomnia in their depressed patients. When I took it at night I'd be drowsy all morning, even with a lot of coffee. I can't imagine it is that useful for dementia. It might put the patients to sleep, and the staff at old age homes might like that.
      Alfa likes this.
    1. mess clean
      It can be sedating but it all depends on indication and dosage. It is an SARI in doses above 150 mg/day. Below 150 mg per day it can be used for insomnia. However, in my use of it, it doesn't have much sedative effect. This is regardless of if I take all 150 mg/night or 50 mg 3x through the day. I've used both dosing options in the past.
      To say that staff at old age homes like it because it puts patients to sleep misses the point of the article and merely focuses on a presumption with no merit.
  2. malsat
    Doesn't trazodone have a degree of anticholinergic activity? That would acutely impair memory and anticholinergics have been linked to dementia, similiar to the link between benzos and dementia.
    1. mess clean
      From what I understand, trazodone actually has little anticholineric effect and is preferred for use in the elderly. However, since it is so sedating and falls are a major cause of injury among the elderly, it isn't often used.
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