Cannabis improves cognitive functioning in bipolar disorder

By chillinwill · Nov 13, 2009 · ·
  1. chillinwill
    Opposite relationships between cannabis use and neurocognitive functioning in bipolar disorder and schizophrenia

    Cannabis use is associated with altered neurocognitive functioning in severe mental disorders, but data are still inconclusive and there are no studies of bipolar disorder. The aim of this study was to investigate the association between cannabis use and neurocognition in bipolar disorder compared with schizophrenia in a naturalistic setting.MethodA total of 133 patients with bipolar disorder and 140 patients with schizophrenia underwent neuropsychological assessments and clinical characterization including measures of substance use. Relationships between cannabis users and neurocognitive function were explored in the two diagnostic groups. Possible interactions between diagnosis and cannabis use were investigated, and findings were controlled for possible confounders. RESULTS: In bipolar disorder subjects, cannabis use was associated with better neurocognitive function, but the opposite was the case for the schizophrenia subjects. There was a statistically significant interaction effect of diagnosis and cannabis use on focused attention (p=0.019), executive functioning (verbal fluency – set shifting) (p=0.009), logical memory-learning (p=0.007) and on logical memory-recall (p=0.004). These differences in neurocognitive function could not be explained by putative confounders. CONCLUSIONS: The findings suggest that cannabis use may be related to improved neurocognition in bipolar disorder and compromised neurocognition in schizophrenia. The results need to be replicated in independent samples, and may suggest different underlying disease mechanisms in the two disorders.

    November 12, 2009
    Psycho Integrator

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  1. chillinwill
  2. adzket
    swim did always feel more stable and with it when smoking mj when they where diagnosed with bi-polar disorder. they always thought it helped before the diagnosis in helping them get out the house and deal with every day situwations as well as memory recal and the like. swim used to asume this was just down to the effects of the mj making them more likly to have to go out and interact with people thus engaging there brain some. shame it can not help with swim's attrousious spelling!
  3. [tanarilla.]
    Sorry, my bunny find it hard to believe that anyone suffering from bipolar could have benefits from regular cannabis use. First of all, this mental health issue involves a high chance of substance abuse and addiction...If a patient was presented with a choice to legally self medicate with mj, then there is a high chance they would eventually abuse it...but that's what most people would do, even if they did not have bipolar. Hey, even my bunny's friend's grandma abuses her prescription for alzheimers.:laugh:
  4. FrankenChrist
    SwiFr has a bipolar buddy who has his art as a release, but he would not be able to sit still and draw a live model for hours on end if he didn't smoke up first.
  5. adzket
    your right it does lead to drug abuse at times how ever this was mainly before swim had a diagnosis so they where basicaly self medicating to deal with there moods and impulses, though they have never over used mj, it has never realy had an abuse potential for swim. mainly because they don't like the real heavy stoned feeling so have always keept use to a min. the only demon they have left is h addiction which is difficult to slay. how ever all other drug use for swim is under control only using a few times a yr. but that is mainly due to meds being right for swim. all they can say is they have noticed a diffirence to how they opperate when smoking to not mostly in a possitve way.
  6. cannademon
    taken from book Kofalvi - Cannabinoids and the Brain (Springer, 2008)

    Taken from book Cannabinoids [Handbook of Experimental Pharmacology 168] - R. Pertwee (Springer, 2005)

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