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  1. Beenthere2Hippie
    View attachment 50965 With the prevalence of Alzheimer's disease expected to almost triple in the United States by 2050, there is an urgent need to identify effective treatments for the condition. Now, a new study suggests marijuana may hold the key to such a treatment.

    Published in the journal Aging and Mechanisms of Disease, the study reveals how a compound present in marijuana triggered the removal of beta-amyloid protein from nerve cells, or neurons. Beta-amyloid is considered a hallmark of Alzheimer's disease; the protein clumps together in the brain of people with the condition, forming plaques.

    Studies have suggested these beta-amyloid plaques disrupt communication between neurons in the brain, which leads to symptoms associated with Alzheimer's, such as impaired memory.

    Preventing beta-amyloid accumulation in the brain might seem like an obvious way to tackle Alzheimer's, but because researchers are still unclear of the exact role the protein plays in the disease process, achieving such a feat is easier said than done.

    High beta-amyloid levels trigger inflammation, nerve cell death

    To find out more about the role of beta-amyloid in Alzheimer's, senior author Prof. David Schubert, of the Salk Institute for Biological Studies in La Jolla, CA, and colleagues modified nerve cells to produce high levels of the protein. The team found that increased beta-amyloid production led to increased expression of pro-inflammatory proteins in nerve cells, causing inflammation and nerve cell death.

    "Inflammation within the brain is a major component of the damage associated with Alzheimer's disease, but it has always been assumed that this response was coming from immune-like cells in the brain, not the nerve cells themselves," notes first author Antonio Currais, also of the Salk Institute for Biological Studies.

    The researchers explain that nerve cells in the brain contain receptors that are activated by lipid molecules known as endocannabinoids. These molecules are naturally produced by nerve cells and are believed to aid nerve cell signaling. Marijuana contains a chemical called tetrahydrocannabinol (THC), which is similar to naturally produced endocannabinoids and activates the same receptors. This got the team thinking: could THC prevent nerve cell death?

    "When we were able to identify the molecular basis of the inflammatory response to amyloid beta, it became clear that THC-like compounds that the nerve cells make themselves may be involved in protecting the cells from dying," explains Currais.

    Marijuana compound prevented nerve cell death

    To test their theory, the researchers applied THC to nerve cells with high beta-amyloid production. They found that the marijuana compound reduced beta-amyloid levels and eradicated the inflammatory response to the protein, which prevented nerve cell death.

    While clinical trials are needed to confirm the role THC might play in protecting nerve cells against beta-amyloid, the researchers believe their findings shed more light on the role beta-amyloid plays in Alzheimer's disease, which could pave the way for new treatments.

    "Although other studies have offered evidence that cannabinoids might be neuroprotective against the symptoms of Alzheimer's, we believe our study is the first to demonstrate that cannabinoids affect both inflammation and amyloid beta accumulation in nerve cells." --Prof. David Schubert



    By Honor Whiteman - Medical News Daily/June 30, 2016
    http://www.medicalnewstoday.com/articles/311347.php
    Graphics: 1-alzheimers.org; 2- nia.nih.gov
    Newshawk Crew

    About Author

    Beenthere2Hippie
    BT2H is a retired news editor and writer from the NYC area who, for health reasons, retired to a southern US state early, and where BT2H continues to write and to post drug-related news to DF.

Comments

  1. Alfa
    Excellent news. I hope this spurs further research into THC treatment of alzheimer's. As well as the effects of cannabinoids on alzheimer. Like CBD related cannabinoids as well as synthetic cannabinoids like CP-47,497 etc.
  2. Booty love
    Its amazing the effects inflammation has on the body and mind.

    I wonder how long the amazing anti-inflammatory properties of the cannabis plant have been known?

    Also getting its anti-inflammatory relief doesnt require getting the psychoactive effects
  3. Beenthere2Hippie
    The credit for finding the story goes to trbofbeingtrd, for his good eyes and for sending it in for DF news for publication. Thanks, trd.

  4. Waiting For The Fall
    I'm currently taking a stack of nootropics to prevent the beta-amyloid buildup as well as herbals to reduce the inflammation. When Texas finally makes marijuana legal (if I'm still alive by then), then I'll add it as backup to the other things. When both of your parents had Alzheimer's and you know you are carrying genes that increase the propensity for it, and you're in your 70s like I am, you feel like you are in a race against time. Keeping dementia and Alzheimer's at bay is a conscious thought every day.
  5. Booty love
    you should be able to legally order CBD oil online. This is all you need to benefit from cannabis' anti-inflammatory properties.

    I think the ordering and shipping of non psychoactive cbd oil is legal in all 50 states
  6. prescriptionperil
    Booty, Inflammation is a killer and I believe the roots of disease.

    This story is ironic.

    I also take a slew of antioxidant with evidence towards neuroprotection.
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