Pharmacology

  1. Efficacy of urine alkalinization by oral administration of sodium bicarbonate

    Abstract BACKGROUND: Urine alkalinization is indicated for various medical conditions. Alkalinization is usually achieved by intravenous administration of alkali substances titrated by repeated urinalyses. Some situations such as mass casualty events might require urine alkalinization by the oral route. We evaluated the efficacy of oral sodium bicarbonate administration for urine alkalinization. METHODS: In a prospective open-label trial, 4 g of sodium bicarbonate was administered orally...
  2. What I learned today

    A growing list... 'Mach bands' are a result of lateral inhibition, which is what the horizontal and amacrine cells do with the information provided by a photoreceptor in order to facilitate better edge perception. 'Parallel processing' is responsible for the possibility of a top down influence from higher order cognitive processes in the association cortex like past experiences to influence sensory perception. 'NMDA receptors' play a key role in a phenomena called long term potentiation...
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