1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
  1. chillinwill
    Dopamine, a chemical with a key role in setting people's moods, could have a much wider-ranging impact on their everyday lives, research suggests.

    Experiments show that altering levels of the chemical in the brain influences the decisions people make.

    One expert said the results showed the relative importance of "gut feeling" over analytical decision making.

    The Current Biology study could help understand how expectation of pleasure can go awry, for example in addiction.

    It follows previous research by the University College London team, which, using imaging techniques, detected a signal in the brain linked to how much someone enjoyed an experience. They found that signal could in turn predict the choices a person made.

    With the suspicion that the signal was dopamine, the researchers set up a study to test how people make complex decisions when their dopamine system has been tampered with.

    The 61 participants were given a list of 80 holiday destinations, from Greece to Thailand, and asked to rate them on a scale of one to six.

    They were then given a sugar pill and asked to imagine themselves in each of 40 of the destinations.

    Researchers then administered L-Dopa, a drug used in Parkinson's disease to increase dopamine concentrations in the brain, before asking them to imagine the other holidays.

    They rated all the destinations again, and a day later they were asked where they would prefer to go, out of paired lists of holidays.

    The extra dopamine gave people higher expectations when rating holiday options.

    And that translated into the choice of trip they made a day later.

    Study leader Dr Tali Sharot, from the Wellcome Trust Centre for Neuro-imaging at UCL, said humans made far more complex decisions than other animals, such as what job to take and whether to start a family, and it seemed dopamine played an important part in that.

    She said they had been surprised at the strength of the effect they had seen.

    "Our results indicate that when we consider alternative options when making real-life decisions, dopamine has a role in signalling the expected pleasure from those possible future events.

    "We then use that signal to make our choices."

    Dr Sharot added that addicts overestimated the pleasure they would gain from something, be it heroin or gambling, because their dopamine system was dysfunctional, and the latest research underpinned that the choices they made would be influenced by that.

    Gut instinct

    She added: "For many conditions we have medication which changes dopamine function, so knowing we may be changing people's expectations and their decision making might change how we think about giving these types of medications."

    Professor John Maule, an expert in decision making, at Leeds University Business School, said that in recent years people had begun to realise emotional or "gut instinct" decision making was just as important in human choices as analytical decision making.

    "At any one time you will have both these processes going on, so it's not surprising to see these results, especially when it comes to emotionally based decisions, such as holidays.

    "It is a sort of shortcut in our thinking."

    January 8, 2010
    BBC News


  1. Eratosthenese
    I can see how that could play an important role in designing a substance that could help people make better decisions in there everyday life. That would be an interesting new class of drug.
  2. jtb
    i think a lot of drugs already do this, just not in an explicit or obvious way. entheogens for example can cause one to view problems with a more objective perspective and allow one to make certain decisions without as much internal bias. swim feels like he makes better social decisions under the influence of a light dose of benzos.. he will be more likely to say things with greater confidence and approach people where he might not have otherwise. amphetamine can make one make better decisions in terms of being productive or getting work done, as can most stimulants.

    there are a lot more examples, but i understand you mean something more of a supplement that doesnt have a pronounced psychoactive character beyond affecting decision making. its an interesting concept because it really makes me think a lot about relying on a drug to be a certain way. like its the idea that perhaps dopamine levels are reflective of one's consciousness and well being as opposed to one's self and decisions and attitude being a product of quantifiable level of chemicals in one's brain. the chicken and the egg of neuroscience.. if dopamine levels are merely a reflection of one's "self" or "soul" then simply taking chemicals to alter them seems as if it would only be a temporary solution, and would be an attempt to cut the corner of one's own growth and development as a human; ultimately, such supplements would be counter productive in the scenario. this is contrary to the idea of an entheogenic experience where the action of spiritual growth and develpoment doesnt lie within altering quantifiable levels of chemicals in the brain, its lies within giving a person an initiative to understand themselves in a different way and then make their own choice accordingly.

    hehe ok that turned into quite a diatribe that im not sure will even be read!
  3. MrG
    Although it should be said that this shortcut isn't necessarily, or even likely, to be the superior method of thinking over objective rationality provided by intellectual thought. The chemical signalling process occurred long before the evolution of the analytical self.

    If anything it is the animalistic drive provided by dopamine in people who are not sufficiently self-aware that is responsible for the heinous acts perpetrated within society. Tie that in with a dysfunctional learning environment and the child grows into a very dangerous adult.
To make a comment simply sign up and become a member!