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  1. chillinwill
    If you are still wondering whether humans were intended to enjoy and benefit from marijuana's main psychoactive ingredient, THC, pick up a copy of Michael Pollan's bestseller "The Botany of Desire." Pollan, a contributor to The New York Times, should be required reading for anyone weighing the pros and cons of marijuana's booming new acceptance, both as a medicine and perhaps further down the line as a recreational drug.

    I stumbled across it while researching my own book on medical marijuana, and this is one of the best I've found explaining the drug's affect on the human brain. Most fascinating to me is the revelation that the brain is pre-wired to accept cannabinoids, the active ingredients in cannabis of which THC is one. Just as the brain has receptor cells for endorphins, serotonin and other chemical compounds, so too are there cells specially designed to pair with cannabinoids to unlock certain mental functions.

    Here' the gist, in Pollan's words:

    In 1988, Allyn Howlett, a researcher at the St. Louis University Medical School, discovered a specific receptor for THC in the brain -- a type of nerve cell that THC binds to like a molecular key in a lock, causing it to activate. Receptor cells form part of a neuronal network; the brain systems involving dopamine, serotonin and the endorphins are three such networks. When a cell in a network is activated by its chemical key, it responds by doing a variety of things: sending a chemical signal to other cells, switching a gene on or off, or becoming more or less active. Depending on the network involved, this process can trigger cognitive, behavioral or psychological changes. Howlett's discovery pointed to the existence of a new network in the brain.

    The cannabinoid receptors Howlett found showed up in vast numbers all over the brain (as well as in the immune and reproductive systems) though they were clustered in regions responsible for the mental processes that marijuana is known to alter: the cerebral cortex (the locus of higher-order thought), the hippocampus (memory), the basal ganglia (movement), and the amygdala (emotions). Curiously, the one neurological address where cannabinoid receptors didn't show up was in the brain stem, which regulates involuntary functions such as circulation and respiration. This might explain the remarkably low toxicity of cannabis and the fact that no one is known to have ever died from an overdose.

    On the assumption that the human brain would not have evolved a special structure for the express purpose of getting itself high on marijuana, researchers hypothesized that the brain must manufacture its own THC-like chemical for some as-yet-unknown purpose. ... In 1992, some thirty years after his discovery of THC, Raphael Mechoulam (working with a collaborator, William Devane) found it: the brain's own endogenous cannabinoid. He named it "anandamide," from the Sanskrit word for "inner bliss."

    So there you have it. Not only is part of the brain designed specifically to react to cannabinoids like THC, but it produces its own in order to achieve effects similar to smoking marijuana, including pain relief, sedation, impairment of short-term memory and cognitive befuddlement. (It should be noted that THC is far stronger and longer-lasting than anandamide, exaggerating and prolonging the effects of the naturally occurring chemical.) Why would the brain want to do this to itself?

    Pollan (and the scientists he consulted with) have a few theories, the most intriguing of which is as a natural curative for the "routine slings and arrows of life." Not only is pain dulled (such as during childbirth; there are cannabinoid receptors in the uterus) but quickly forgotten.

    Another possibility is that the brain equips us with the natural ability to be amused and excited by our surroundings, that it allows us (through the activation of these cannabinoid receptors) to forget what we know, however mildly, and see the world anew from time to time through the lens of suspended knowledge and rediscovery. As anyone who has ever been high knows, this is one of the main pleasures of the experience -- hearing a song as if for the first time, appreciating textures and colors more fully, being much more intimately aware of one's tactile surroundings.

    Such experiences might seem like a waste of time to those who rail against marijuana as the "devil's weed," but evolution apparently considered them valuable enough to develop an entire neural network devoted to their pursuit.

    And who's to argue with your own brain?

    By Greg Campbell
    April 7, 2010
    Green Zone


  1. dmtHELLA
    Re: Evolution and cannabis -- human brain is hard-wired to experience marijuana's hig

    oh my gosh the brain is made to accept cannabinoids?

    how amazing!

    this is so much different then the bodies natural use of opioids!
    or the bodys tendency to accept nicotine in it's nicotine receptors!
    or how it uses DMT!

    people people please.
  2. dmtHELLA
    Re: Evolution and cannabis -- human brain is hard-wired to experience marijuana's hig

    what this article doesnt tell you is that anandamine activates the short-term memory loss channel and THAT is what causes all those happy feelings.

    Simply put
    America = Hard Work
    America + Weed = Lazy Work
  3. Joe-(5-HTP)
    Re: Evolution and cannabis -- human brain is hard-wired to experience marijuana's hig

    How correct is this evolutionary argument? Do the cannabinoid receptor systems serve no other function in the body other than to respond to cannabinoids?
  4. b3ni
    Re: Evolution and cannabis -- human brain is hard-wired to experience marijuana's hig

    I love that attached picture of the brain. It shows a baked journalist wasting some time on Ms Paint.
  5. Paradox
    Re: Evolution and cannabis -- human brain is hard-wired to experience marijuana's hig

    I've read this book, and the article is entirely off base. Pollan talks about how anamandine works in the body as a natural "forgetful" molecule and how the endocannabinoid system works, then he relates this to how cannabis effects the human brain and perception. He doesn't say that "we evolved to smoke pot." The author of this article seriously misread or misinterpreted the book.

    The short term memory disruption, especially when controlled endogenously, can be highly beneficial to the human experience. Just like endogenous endorphines. If the brain wanted people to be high all of the time, it would overexpress the endogenous cannabinoids.

    In other words "Omigosh, our bodies respond to this chemical! We must have evolved to react to this chemical!" is inane logic. Cannabis, just like most psychoactive drugs hijacks internal brain function. This has positive and negative benefits. Cannabis evolved to effect the brain (and this is what Pollan ACTUALLY says) rather than the brain evolving to effect cannabis.
  6. Terrapinzflyer
    Re: Evolution and cannabis -- human brain is hard-wired to experience marijuana's hig

    Should point out that PBS (I think- may have been BBC) did a documentary on this book- and researchers pointed out the marijuana/brain receptor link revolutionized understandings of how the brain works - got them to investigate things they had not previously considered.

    Polan also makes an excellent case in the book that changing ones consciousness is a part of human history and one that can not/should not be legislated. It is more a biological imperative then a choice. I can not recommend the book and documentary highly enough.
  7. corvardus
    Re: Evolution and cannabis -- human brain is hard-wired to experience marijuana's hig

    Think Horizon did a documentary on this am not sure if this is the one you are referring to, but Horizon tends to make good documentaries so this might be an interesting watch.

    I have linked the first Video if a 5-video set to the site, click on the first and you have the rest to the side of them.

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