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Generic version of drug linked to Michael Jackson recalled (Diprivan/Propofol)

By Phungushead, Jul 15, 2009 | | |
  1. Phungushead
    Generic version of drug linked to Michael Jackson recalled

    art.diprivan.fda.jpg Two tainted lots of a generic version of a drug reportedly taken by Michael Jackson have been recalled by the drug maker.

    However, no link has been established between the drug -- a powerful sedative and anesthetic called propofol -- and the singer's death.

    "I have no way of knowing anything related to this specific product -- if it might have played a role or not played a role," said Dr. Arjun Srinivasan, the chief investigator on the recall for the Centers for Disease Control and Prevention.

    The agency is not involved in the investigation into Jackson's death, he said.

    The CDC issued a health advisory Monday, saying two lots of a generic version of the drug had tested positive for endotoxin, a contaminant. The drug maker, Teva Pharmaceuticals, voluntarily recalled the lots.

    Srinivasan said the agency received 40 reports of patients around the country developing high fevers and muscle aches after being injected with the drug.

    "All of the cases had high fevers, some muscle aches, headaches, but no issues with heart problems that we were told of," he said.

    Jackson died June 25 of cardiac arrest. The exact cause of death is pending toxicology results.

    All of the people who had taken propofol recovered; only one was hospitalized and that patient was quickly discharged, he said.

    But, he added, "at high doses, endotoxin can absolutely cause lowered blood pressure and much more serious reactions."

    "It can cause decreases in blood pressure, which could precipitate problems with your heart."

    The manufacturer, Teva Pharmaceuticals, is working with the Food and Drug Administration to determine how the contamination occurred and is voluntarily recalling the affected lots, he said.

    A spokeswoman for Teva said about 57,000 vials were included in the recall of the drug, and said the company had been contacted by the Drug Enforcement Administration.

    "I can say the DEA did contact us about a specific lot number, and that lot number is not from the two we are recalling," said spokeswoman Denise Bradley.

    She would not say whether the contact was related to the Jackson investigation.

    A DEA spokesman did not immediately return a call seeking comment.
    The Associated Press and the Los Angeles Times, citing unidentified sources, have reported that police found the drug Diprivan, a brand-name version of propofol, among Jackson's medicines.

    A source involved with the probe into Jackson's death told CNN that investigators found numerous bottles of prescription drugs in his $100,000-a-month rented mansion in Holmby Hills, California.

    ProPublica, an online news organization, first reported a possible link between Jackson's death and the drug recall on Tuesday.

    But an FDA spokeswoman denied there could have been a link.

    "This is fever, chills," said Karen Riley. "Does that sound like heart failure?"
    She said at least three companies make the generic version of the drug and only one of them -- AstraZeneca -- makes Diprivan, the brand-name version.

    "We don't know what was at Michael Jackson's house, but I'm guessing it was Diprivan because that's what the reporting has been," Riley said. "This [the propofol recall] was endotoxin in the drug. It would not cause heart failure. ... It's unrelated."

    Authorities have said the cause of Jackson's heart failure will not be determined officially until toxicology tests are complete.


    July 14, 2009
    CNN
    http://www.cnn.com/2009/HEALTH/07/14/jackson.drug.recall/

Comments

  1. Handle
    Propofol! I checked, this thing sounds like it would not be too difficult to synth, not for me, I mean for a profesional, but I can't find the law on this stuff, i can't find out basically anything about how it's made, all I know is its related to tetse fly attractant pheromone that mimicks the smell of buffalo or something.

    Diisopropyl phenol, and it comes in a milky emulsion, and also, it has relatives that function much more like benzo's, that could be recreational.

    Rhodium has no file on the synth, I checked. Nobody seems to have a clue. It's a nice, simple, symmetrical molecule, is it, I mean would it be easy or hard to make?
    [again I say, not for me, i mean for someone with a bit of skill. For instance, if someone could make meth, could they make this?]
  2. enquirewithin
    Michael Jackson doctor charged in singer's death

    Michael Jackson's doctor was today charged with involuntary manslaughter, capping an exhaustive investigation into the pop star's stunning death last summer and setting up the prospect of another sensational celebrity courtroom drama.

    Dr. Conrad Murray, a cardiologist who was with Jackson when he died June 25 at his rented Los Angeles mansion, is accused of acting "unlawfully and without malice" in bringing about Jackson's death, according to a complaint filed by prosecutors.

    The complaint said Murray acted "without the caution and circumspection required" when he administered a powerful sedative to Jackson in an effort to help him sleep.

    The charge was expected, and Murray's attorney, Ed Chernoff, said his client planned to surrender to authorities later today.

    "We'll make bail, we'll plead not guilty and we'll fight like hell," Chernoff said before the charge was filed.

    Jackson hired Murray to be his personal physician as he prepared for a series of strenuous comeback concerts in London. Officials say the singer died after Murray administered the powerful general anesthetic propofol and two other sedatives to get the chronic insomniac to sleep.

    Los Angeles investigators were methodical in building a case against Murray, wary of repeating missteps that have plagued some other high-profile celebrity cases, most notably O.J. Simpson and actor Robert Blake, both of whom were acquitted of murder.

    After reviewing toxicology findings, the coroner ruled Jackson's death at age 50 a homicide caused by acute intoxication of the powerful anesthetic propofol, with other sedatives a contributing factor.

    Propofol is only supposed to be administered by an anesthesia professional in a medical setting, because it depresses breathing and heart rate while lowering blood pressure.

    Murray appears to have obtained the drug legally and its use is not in itself a crime. To show the doctor was negligent in his care, detectives spoke to more than 10 medical experts to see if his behavior fell outside the bounds of reasonable medical practice.

    According to court documents, Murray told police he administered propofol just before 11 a.m. then stepped out of the room to go to the bathroom.

    There is some dispute about what happened next. According to court filings, Murray told police that upon his return from the bathroom, he saw Jackson was not breathing and began trying to revive him.

    But an ambulance was not called until 12:21 p.m. and Murray spent much of the intervening time making non-emergency cell phone calls, police say. The nature of the calls, which lasted 47 minutes, is not known.

    Murray's lawyer has said investigators got confused about what Murray had told them, and that the doctor found his patient unresponsive around noon.

    The investigation included several agencies, including the Los Angeles Police Department, the district attorney's office and the federal Drug Enforcement Administration.

    Many witnesses have been interviewed by police, including those who were present during Jackson's last days, those who worked with him in preparation for his series of comeback concerts, "This Is It," and members of his personal entourage, including his security guard and personal assistant.

    Members of Jackson's family later arrived at the Los Angeles court house where prosecutors had announced they had charged Murray.

    Jackson's father Joe said he was "looking for justice".

    Mr Jackson and his wife Katherine arrived at the court house adjacent to Los Angeles International Airport around noon. Also there were the pop star's brother Jermaine and several other family members.

    Michael Jackson doctor charged in singer's death
    By Linda Deutsch, Associated Press Monday, 8 February 2010


    http://www.independent.co.uk/news/w...-doctor-charged-in-singers-death-1893274.html
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