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How Black Pepper Relieves Cannabis Anxiety

By Phungushead, Aug 23, 2014 | | |
  1. Phungushead
    View attachment 39980 While working at the Victoria Cannabis Buyers Club I was able to teach some of the members about Black Pepper. While benefiting from the medicinal effects of THC, these patients suffered from bouts with anxiety while medicating. Most patients who have tried this simply took a few sniffs of the black pepper to receive an almost immediate effect. Others have reported that after chewing on pepper corns they felt relief within an hour, but that may be a delay most would seek to avoid. So how does this work? The Aug. 2011 British Journal of Pharmacology: Cannabinoids in Biology and Medicine, Part 1 includes numerous articles exploring the nature of the cannabis plants’ chemical dynamism. In the article “Taming THC,” scientists report having discovered more than a hundred terpenes that “may contribute meaningfully to the entourage effects of cannabis-based medicinal extracts.” Terpenes create the many scents of cannabis and are shared among the plant kingdom. Scientists explored how these aromatic oils synergize and mitigate the active cannabinoids contributing to an entourage effect.

    Cannabis in known to produce a wide variety of effects from rendering a individual wide-awake to sending them into a sound sleep. Growers have been tailoring their heirloom heritage varieties of cannabis to uniformly exhibit certain cannabinoid/terpene profiles to produce particular effects. CBD is quickly becoming an essential component to combat the unwelcome effects of using THC rich cannabis, such as anxiety. Another option may be to introduce terpenes from other plant sources to mitigate the effects.

    Ed Rosenthal, author of many books on cannabis, relates that the myrcene in mangos can increase the quality of low potency cannabis when eaten one hour before medicating. Anecdotal evidence suggests that the terpene alpha-pinene is alerting, limonene is “sunshine-y,” and beta-myrcene is sedating. As the names suggest, pinene is abundant in pine needles and limonene in lemons. Traditional responses to cannabis induced anxiety include pinene-rich black pepper, limonene-rich citrus, and calamus root high in myrcene. Myrcene is also found in hops (Humulus), the only other member of the Cannabaceae plant family. “Cannabis terpenoids and flavonoids may also increase cerebral blood flow, enhance cortical activity, kill respiratory pathogens, and provide anti-inflammatory activity.”

    View attachment 39978

    Scientists have discovered that beta-caryophyllene (BCP), which is another terpene that contributes to the aroma and flavour, also found in other herbs, spices, and food plants, activates the CB2 receptor and acts as a non-psychoactive anti-inflammatory. Because it binds to a cannabinoid receptor [...] and since it is an FDA approved food additive and ingested daily with food, it is the first known dietary cannabinoid.(source) Leading the way on terpene identification is a seed company in Holland who have performed spectral analysis of each of their strains and developed a flavour wheel identifying 16 different terpenes to help individuals decide on their strain of choice.

    Cannabis Science Inc. is exploring the possibility that certain terpenes act as building blocks for the production of cannabinoids, with the hope that this will open up to cultivators the opportunity to manipulate cannabinoids to desired ratios. they are exploring how terpenes act synergistically with other terpenes to either catalyze or inhibit the formation of other compounds within a plant.

    Up until now, drug companies have been focusing on single synthetic compounds that can be patented and brought to market. In light of these discoveries, scientists isolating cannabinoids into synthetic compounds have to consider the terpene interaction as another variable potentially responsible for the plants therapeutic effects. Cannabis grown with care and attention to the curing process will contain more terpenes. Many terpenes are FDA approved and therefore easy to obtain for testing.

    17 July 2014

    Owen Smith
    Cannabis Digest


  1. Adas
    Yesterday I took about a handful of black pepper with some chocolate and felt a bit floaty, maybe relaxed, and I think that my overall perception of my surroundings has changed. Might have been the tiredness but there was definitely something going on.

    Could anybody try the combo with cannabis?
  2. best
    Adas, its likely that the Black Pepper elevated your Anandamide levels in that situation.
    Black Pepper was shown to have a Anandamide Reuptake Inhibitor https://www.infona.pl/resource/bwmeta1.element.elsevier-775cc536-c9f3-3e8d-903a-940219266f6b

    And also Black Pepper is shown to inhibit CYP3A4 & CYP2D6 which can prevent Anandamide from Metabolizing into other things according to some sources, plus Piperine is shown to agonize TRPV1; capsaicin was used in a study that showed anandamide is released via TRPV1 Agonism. Anandamide Itself is also listed as a TRPV1 Agonist.

    Also, 60% Macamides Extract (also shown to be a Anandamide Reuptake Inhibitor plus FAAH Inhibitor), can be very delicious and may enhance effects of cocoa like how the black pepper worked (although likely with less efficaciousy).

    The Macamide extract tastes sweet and smooth caramel like compared to regular Maca powder.

    But anyways i also would like to hear how black pepper combines with Marijuana.
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