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Integrated sensing platform [drugs and doping agents detection in human fluids]

By YIPMAN, Jan 6, 2012 | Updated: Jan 6, 2012 | |
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  1. YIPMAN
    IRSENS: Integrated sensing platform for gases and liquids in the near and mid-infrared range

    The aim of this project is to create a photonic sensor platform with high performance and reliability. This platform will leverage on the new source, detector saskia clothing design and interaction cell technologies to create a new sensor element with vastly improved performance and lowered cost. These improvements will be demonstrated further by the incorporation into two pilot applications, the first one aiming at the clothing fashion design demonstration of the sensing in the gas phase, ] the second one in the liquid phase. The two SEO Melbourne sensors will be developed in parallel and they will share some common points, namely the optical absorption spectroscopy technique, the compactness of the sensor, and an integrated approach concerning the components business marketing of the sensor (source, interaction region and detection) resulting in an integrated sensing platform like managers.

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    The second main objective of this project consists in developing an integrated sensing platform for fluids based on infrared laser spectroscopy in silicon based systems. The basic idea is to develop a multiwavelength semiconductor laser source based on either mid-infrared QCLs or on near-infrared VCSELs and to couple them to a silicon based optical module where the liquid analyte will flow through a built-in micro-fluidic channel. The integrated approach to this sensor will imply the development of a broadband silicon based detection element being responsible also for the data acquisition. The described platform is intended to be used mainly in bio-medical applications with a particular emphasis on drugs and doping agents detection in human fluids, and it would take advantage of a high sensitivity performance together, with the very small volume of specimen needed for the analysis. A first targeted demonstrative application for this sensor would be the cocaine detection in human saliva...

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    2012-01-02 14:23:57

    http://www.nano-tera.ch/nanoterawiki/IRSENS

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    Infrared attenuated total reflection (IR-ATR) spectroscopy for detecting drugs in human saliva

    Kerstin M.-C. Hans, Susanne Müller, Markus W. Sigrist
    Article first published online: 24 NOV 2011

    DOI: 10.1002/dta.346


    Keywords: infrared spectroscopy;cocaine;metabolites;human saliva;evanescent field

    Abstract

    The consumption of drugs is of great concern worldwide. Various drug tests for humans have been developed but there is no compact and easy-to-use test device available yet for direct semi-quantitative drug testing in the field. We suggest using attenuated total reflection (ATR) infrared spectroscopy as a sensing method to analyze human saliva samples with respect to drugs. In this paper, we present ATR spectra in the infrared range between 2300 and 900 cm−1 as a first step towards such a device. We emphasize the common drug cocaine and its metabolites and investigate the problems of spectral interferences of selected diluents, masking agents, common medication, and soft drinks. Furthermore, spectra of saliva samples are recorded and a time-dependent change of the spectral signatures after alcohol consumption is presented. To the best of our knowledge, it is the first time that not only spectra of the drug of interest (cocaine) dissolved in water and in saliva but also spectra of interfering compounds possibly present in the saliva sample of a tested subject are discussed. This paper presents the most appropriate spectral range for strong cocaine absorption (including its metabolites) and minimum interference by the investigated substances. This spectral window is found to be between 1800 and 1710 cm−1. In addition, we demonstrate the feasibility to identify cocaine in saliva at a concentration of 0.020 mg/ml with IR-ATR-spectroscopy without any separation or extraction procedures. For example, this technique could also be applied for drug detection in waste water. Copyright © 2011 John Wiley & Sons, Ltd.

    Source: http://onlinelibrary.wiley.com

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    Additional information, see: Article "Detection of cocaine in saliva"
    http://www.lss.ethz.ch/research/projects/cocaine


    Image Source - see attachment:
    Sensing cocaine in saliva employing a one-step extraction and MIR spectroscopy
    http://www.nano-tera.ch/pdf/posters2011/0-0-3-1.png

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