ORLANDO, Fla. — Preoperative intravenous ketamine chloride with a subsequent infusion of the drug during or around the time of lumbar surgery reduced morphine use in opiate-dependent chronic back pain patients in a prospective randomized study conducted at Dartmouth Hitchcock Medical Center in Lebanon, N.H.
Dilip K. Sengupta, MD, who presented results of the 102-patient study at the 2010 Annual Meeting of the North American Spine Society, said patients receiving the protocol were compared with a control group that received saline. “For the 24 hours and the 48 hours postop period, the study group had much less requirement of morphine or morphine equivalent and they had much better pain control. Their pain score during that period was much softer or much easier in the study group and even at 6 weeks the same result persisted,” he said.
Both groups were similar in terms of demographics and levels treated and no more adverse or hemodynamic events occurred in the study group compared with controls.
“It was more interesting to find that those patients who were more narcotic or morphine dependent, had a better treatment effect in the study group,” Sengupta noted.
He said these conclusions only apply to surgical patients and therefore should be interpreted with caution.
However, at a recent anesthesia meeting, where Sengupta presented the findings, three papers on this topic all arrived at similar conclusions.
Posted on the ORTHOSuperSite
October 7, 2010
Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.