modafinil article

By Heretic.Ape. · Jun 23, 2007 · ·
  1. Heretic.Ape.
    It might be useful for judges and soldiers - but there are drawbacks
    Dr Thomas Stuttaford: Medical Briefing

    Modafinil first came to the public notice when it was suggested that this was the ideal pill to ensure that judges stayed awake in the court room and that it might have the additional advantage that it might make their already-keen brains even sharper.
    Reports about the clinical use of modafinil first appeared in the journal Neurology in 1997; the following year an even larger study was published in the Annals of Neurology about an American trial of the drug. Following these initial research papers there has been a host of other papers describing its use in different neurological conditions. It is now the drug of choice in treating narcolepsy, which can cause an overwhelming need to go to sleep, often at inconvenient moments. Modafinil is also prescribed to counteract the tiredness associated with shift working, and in those who suffer from sleepiness or lack of energy as the result of obstructive sleep apnoea (loud snoring and restless sleep).
    The Army, which during the Second World War used amphetamines to keep soldiers awake, is said to have stocks of modafinil as it is safer than amphetamines and is not thought to be addictive. However, psychological dependence can develop and it has many potential side-effects. It should not be taken by those who have cardiovascular problems, liver or kidney disease.
    Within the past two or three years it has been tried as a drug that might sharpen up the intellects of people who have suffered strokes, and in general it does seem to have the ability to improve short-term memory.
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    As with any useful drug there is the possibility of abuse and misuse. Some students take modafinil so they can work all hours of the day and night. They don’t realise that the brain, like any other organ, needs periods of rest in between activity if it is to give its best performance.
    If someone continuously takes a stimulant day after day to cut down on sleep, they are likely to become sleep deprived. They will then become tense, edgy, irritable, aggressive and even confused and paranoid. Not the ideal mindset to have before sitting an exam.
    There is a well-known danger that athletics contests can degenerate into a competition between pharmacologists rather than sportsmen.
    It would be even more socially destructive if the difference between a first and a second at a university was determined by the skill of the student doctors’ and their understanding of pharmacology rather than the inherent ability of the student.
    The drugs
    — Licensed in 1997, it is used to treat narcolepsy and other sleep disorders. Helps users to stay awake when needed but still sleep at night. Is not a cure but reduces sleepiness
    — Sold under the name Provigil; Modafinil is the active ingredient
    — Less likely than Ritalin to cause jitteriness; side-effects can include headaches
    — Licensed in 1997, it is used for attention-deficit hyperactivity disorder. Children with ADHD tend to be restless and find it difficult to concentrate
    — Its active ingredient is Methylphenidate hydrochloride
    — Side-effects can include headaches, loss of appetite, jitteriness
    Sources: Cephalon/; Novartis

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  1. stoneinfocus
    Mh, so if someone is good at achieving something, he´s in fact cheating and not good? -wow, seems I´ve always gotten something wrong in the first place.
  2. seechao
    Silly anti-drug paranoia clouding people's minds, if inteligence can be increased, by any means, then it should be allowed, if not encouraged. If the risks and negatives do not outweigh the benefits, it seems like simple common sense to increase your inteligence, and productivity levels, many people will weight differant risks or negative effects differantly, some people wont read books because it keeps them from having the personal life they think they need, some people will only eat rabbit food, and others, like myself, have no problems with using chemicals and herbs responsibly. It's not cheating, no more than yoga, meditation, ginseng, ginko biloba, or even a healthy diet, which will all increase your mental performance and energy levels as well... However, what seems to stand out most here is the comparisson with sport... a competiton, college tests are not competitions, they are simply a way of finding out what a student knows, and whether or not the student has injested a stimulant durring the test, or while studying for it, does not change the fact that if he dosnt know the answer to a question, he wont be able to answer it.
  3. stoneinfocus
    Its´the same as in sports, if you you´re not talented and disciplined and a training/biochemical/medical genius, you can take as much stims and anabolics as you want and won´t even finsih or lose/do a competition in any significant way, as would do any talented sportsman would do, you were just a disturbing charachter, slightly lowering the chances of a talented competitor to other talented competitors.

    It comes to mind, that soemthing with a significance will be spotlighted with all its positives and negatives while some god seling "Bio"-rubbish might be cancerogenic, sensitvising, hyperallergical and have many more downsides, yet unknown, than something that had passed medical evaluation and is then given a bad reputation by some monkeys, always overstating the dangers and "forseeing" hell on earth, if there actually is "something" with this subnstance, that´s not as save or well put like praying and fuckin your newly married virgin.
  4. old hippie 56
    Another article about Provigil from EurekaAlert.

    Brain-boosting pill alleviates post-chemotherapy fogginess

    A drug described by some people as a “genius pill” for enhancing cognitive function provided relief to a small group of Rochester breast cancer survivors who were coping with a side effect known as “chemo-brain,” according to a University of Rochester Medical Center study.

    Sixty-eight women, who had completed treatment for breast cancer, participated in an eight-week clinical trial testing the effects of modafinil (Provigil). All women took the drug for the first four weeks. During the next month half of the women continued to receive the drug while the other half took an identical looking placebo pill. The women who took modafinil for all eight weeks reported major improvements in memory, concentration and learning.

    “I am very enthusiastic about the potential we’ve demonstrated,” said Sadhna Kohli, Ph.D., M.P.H., lead author of the study and a research assistant professor at the University of Rochester’s James P. Wilmot Cancer Center. “This is a novel drug and after completing the trial, many of the women wanted to know how they could continue to get modafinil.”

    Kohli presents the research -- which is believed to be the first to examine the drug’s use in breast cancer patients -- on June 3 at the American Society of Clinical Oncology meeting in Chicago. ASCO is honoring Kohli with a Merit Award.

    Originally licensed to treat narcolepsy, modafinil promotes wakefulness and seems to boost brainpower without causing the jittery, restless feelings induced by amphetamines. Modafinil is part of a class of drugs called eugeroics, which stimulate the brain only when it is required. The effects of modafinil disappear in about 12 hours. For this reason, sleep-deprived college students, athletes, soldiers or others who want to gain an edge in a competitive environment sometimes seek out the drug, calling it a “genius pill.”

    The application for cancer care is unique and entirely appropriate, Kohli said. Although some in the scientific community doubt the existence of “chemo-brain,” many cancer patients insist they are suffering from an impairment of brain function after chemotherapy and desire some form of relief. In a separate study last year, Kohli found that 82 percent of 595 cancer patients reported problems with memory and concentration. Importantly, the deficits can lead to job loss or social dysfunction.

    Scientists have not yet discovered the precise cause of “chemo-brain.” A separate research group at the University of Rochester is investigating the toxicity of cancer-killing drugs on healthy brain cells. In 2006 they showed that chemotherapy disrupts cell division in the hippocampus, the brain region essential for learning and memory.

    Until now, cancer patients had few options. Some studies have tested Ritalin, which stimulates the central nervous system. But Ritalin has unwanted side effects like headaches, irritability and addiction, Kohli said. Since modafinil does not linger in the body, side effects are minimal, according to recent studies.

    Initially, researchers looked at whether modafinil might help alleviate fatigue, another persistent side effect, given the drug’s use in narcoleptic patients. Once researchers saw the drug’s positive effect on fatigue, they conducted secondary analyses to assess whether modafinil could improve the breast cancer patients’ memory and attention skills.

    Results showed the women had a faster memory and could more accurately recognize words and pictures after four weeks on the drug. The ability to focus attention, however, did not change at first. But after taking modafinil for another four weeks, attention deficits improved and memory was even greater. Larger studies are still needed to confirm the results.

    Cephalon Inc., the maker of modafinil, and the National Cancer Institute funded the research.
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