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  1. ZenobiaSky
    (NEW YORK) -- A single injection of Botox, which is typically used to improve the appearance of facial wrinkles, may be an effective treatment for depression.

    Investigators at the Hannover Medical School in Germany found that treating the facial muscles involved in emotion with Botox eases symptoms of depression.

    "Our emotions are expressed by facial muscles, which in turn send feedback signals to the brain to reinforce those emotions. Treating facial muscles with botulinum toxin interrupts this cycle," study investigator Prof. Tillmann Kruger said at a press conference at the American Psychiatric Association's 2014 Annual Meeting.

    Novel Approach

    According to the investigators, positive effects on mood have been seen in patients who've had Botox treatment for the frown lines in the area above the nose and between the eyebrows. To confirm these results, Kruger and colleague M. Axel Wollmer, MD, from the Asklepios Clinic North Ochsenzoll in Hamburg, Germany, did research on Botox injection as an additional treatment for major depression.

    A total of 30 patients with high levels of chronic and treatment-resistant depression were enrolled in the study. Patients were randomly assigned to receive a single injection of Botox or a single injection of saline placebo ("fake treatment").

    Six weeks after a single treatment, the Botox group had an average 47.1% reduction in depression symptoms vs. 9.2% in the placebo group.

    The investigators found that the effect size was even larger at the end of the study. Improvement was also reflected when other tools were used to measure depression symptoms.

    Kruger said Botox may offer a "novel, effective, well-accepted, and economic therapeutic tool for the treatment of major depression."

    These findings have since been repeated in two other studies.

    The researchers are also testing Botox’s therapeutic potential in other psychiatric disorders.

    Jeffrey Borenstein, MD, president and CEO of the Brain and Behavior Research Foundation in New York City, said at the press conference that pursuing new treatments for depression is "crucial."

    Borenstein said he'd like to see this line of research pursued in studies that include larger numbers of patients.

    Dr. Kruger, Dr. Wollmer, and Dr. Borenstein report no relevant financial conflicts of interest.

    These findings were presented at a medical conference. They should be considered preliminary as they have not yet undergone the "peer review" process, in which outside experts scrutinize the data prior to publication in a medical journal.

    By Caroline Cassels
    Medscape Medical News
    June 19, 2014

    The Newhawks Crew


  1. kumar420
    I'm skeptical. You would think more youthful appearance>feeling better about yourself> neurotransmitter boost. But hey, that's probably why I don't have a PhD.

    I can't see this becoming a widely used treatment. Even the most progressive doctor would balk at prescribing botox injections for depression (thank god plastic surgeons aren't licensed to treat depression).

    IMO civilized society needs to wake up and realise all women are beautiful in someone's eyes, not just thin waisted, perky boobed, thigh gap toting women. I blame the media. While some of the responsibility lies wiyh men for being horndogs, its the media who have perpetuated this obscenity. And hence most of the world's 'sexiest' women fall into this category. I've seen many downright sexual girls who don't fit this stereotype and are down on themselves because of it. Combine that with regular teenage/early 20s angst and its a very toxic combination. Very sad.
  2. ZenobiaSky
    Local doctors using Botox to fight depression

    [IMGL=WHITE]https://www.drugs-forum.com/forum/attachment.php?attachmentid=39506&stc=1&d=1405651747[/IMGL] AUSTIN (KXAN) — “We didn’t want people who wanted free BOTOX, they had to be clinically depressed,” said Austin psychologist Michelle Magid who has treated thousands of people with major depression, as she explained a recent study that shows Botox can be used to fight depression.

    “What I do is I see significantly ill patients, treatment resistant patients, the most severe depression,” says Magid, a specialist in treatment-resistant depression.

    According to a recent survey, 20 million Americans suffer from depression including ten percent of Texans. Of those, Magid says, a third of the patients are treatment resistant, meaning they don’t respond to medications or psychotherapy.

    “There has to be other options out there,” Magid says.

    Magid turned to someone she knows all too well in her search for answers.

    “So I’m a psychologist and he’s a dermatologist. We tend to talk about a lot of medicine at night,” says Magid pointing to her husband Dr. Jason Reichenberg. Together, the doctors questioned whether the cosmetic medicine known as BOTOX and used by many dermatologists including Reichenberg to treat frown lines between the eyebrows could help in treating depression.

    “Botullin intoxin causes the nerve to not make the muscle move as much,” Reichenberg explains about the popular procedure.

    Mental health experts suggest frown lines are one indicator on your face that shows how one is feeling. Meaning we carry our emotions on our face by smiling when we are happy or frowning when we are sad. The doctors wondered if BOTOX could keep one from frowning less could it lead to less depression.

    “We had to be careful, we didn’t want people who wanted free BOTOX, they had to be clinically depressed,” Reichenberg said.

    “I felt different.”
    The doctors chose 30 clinically depressed and first time BOTOX users including Brittany Whittenberg to be part of the study.

    “When you are at your lowest point you’re willing to try anything,” Brittany says. She was diagnosed with major depression in 2011. She says her facial expressions of constantly frowning and furrowing her brows reflected how sad she felt on the inside.

    “Maybe it’s something I do all the time. I don’t even know I’m doing it, it just happens. So maybe that’s making me approachable and people don’t feel comfortable approaching me,” she said.

    The 24-week-long study was as follows: For 12 weeks, 19 patients received a placebo injection, 11 patients received BOTOX injections in the forehead. The doctors studied the patients’ symptoms of depression then switched the groups at 12 weeks and studied the patients for the remainder of the 6-month-long study.

    Patients were allowed to stay on previously prescribed psychiatric medications, the BOTOX was an added treatment. However, four patients were not taking any medication at the time and the BOTOX injections were the sole treatment.

    “I felt different,” says Brittany, who was in the first group to receive the BOTOX injections. She says she looked and felt a significant difference, less depressed.

    The doctors say the results of the study were “pleasantly surprising,” according to Dr. Magid. “What we found was in the botulinum toxin (BOTOX) group there was a 42-percent reduction in depression symptoms. Whereis in the placebo there was a 15-percent reduction.”

    While the doctors were intrigued with the results they were also looking for answers as to exactly how the BOTOX can change a depressed patient’s mood.

    “That’s the big question and we don’t necessarily agree on it,” says Reichenberg.

    The doctors say there are two theories as to why BOTOX may lead to less depression. Dr. Reichenberg’s theory is biological.

    “If you are thinking of botullum toxin (BOTOX) as depressing the nerve activity just to these specific muscles then your brain doesn’t feel it that you are frowning.” He adds, “your brain stops having that feedback and there are actual chemical changes that reduce all the signs of depression and anxiety.”
    Dr. Magid suggests the effects are more of a social theory.

    “The more you smile, the happier you feel. The more you frown the sadder you feel. So it’s not the other way around, it’s not that you frown because you’re sad. It might be you’re sad because you frown,” Magid argues.

    Whatever the reason, the doctors hope for a bigger study to catch the attention of the Food and Drug Administration which can ultimately approve the use of BOTOX to treat depression, doing so would clear the way for insurance coverage for the nearly $300 treatment.

    A spokesperson for the FDA tells KXAN News “information about plans to seek FDA approval for additional uses of Botox would need to be addressed by the drug company. Under the law we are not able to disclose that information.”

    The makers of BOTOX have not responded to KXAN’s request for information.

    In May, the doctors’ research study was published in the Journal of Clinical Psychiatry.

    The doctors are hopeful and say the results show while the cosmetic effects of BOTOX usually wear off in 3-4 months, patients in their study felt less depressed for as long as six months.

    “Something is changing the brain to keep the antidepressant effects going even though the cosmetic effects wear off,” adds Dr. Magid. That finding brings a smile to Brittany’s face, “the idea of helping my mood and helping me through a major depressive episode is definitely very hopeful.”

    We wanted to know about potential side effects of Botox; The Mayo Clinic says the treatment is relatively safe when performed by an experienced doctor.

    The most common side effects are swelling or bruising at the injection site, sometimes headache or flu-like symptoms.

    If the injections are in the wrong place, the Botox could spread to other areas, causing eyelid droop, cockeyed eyebrows, a crooked smile, dry eye or excessive tearing.

    And while it’s very unlikely, there is a possibility that the Botox could further spread to other parts of the body, causing muscle weakness, vision problems, trouble speaking or swallowing, trouble breathing, and loss of bladder control.

    Doctors also say you shouldn’t use Botox when you’re pregnant, because it’s unknown how it could affect the baby.

    By Sally Hernandez
    Published: July 17, 2014, 6:00 pmUpdated: July 17, 2014, 8:40 pm

    The Newhawks Crew
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