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New antibiotic that attacks MRSA found in ocean microbe

By Rob Cypher, Aug 1, 2013 | |
  1. Rob Cypher
    A completely new and unusual antibiotic compound has been extracted from a marine microorganism found in sediments off the coast of California.

    The discovery of genuinely novel antibiotics is rare, and experts say resistance to the drugs poses a grave threat to human health.

    US scientists say the new compound, called anthracimycin, seems to be effective at killing MRSA and anthrax.

    Details appear in the German journal Angewandte Chemie.

    The unique chemical structure of the compound could lead to up a new class of antibiotic medicines.

    Thomas Frieden, director of the US Centers for Disease Control and Prevention, recently warned of the risk posed by antibiotic-resistant "nightmare" bacteria while Sally Davies, UK Chief Medical Officer described them as a "ticking time bomb" that threatens national security.

    The Infectious Disease Society of America has expressed concern that the rate of antibiotic development to counter resistance is insufficient. This makes this latest discovery particularly welcome news.

    The structure of anthracimycin, described by Kyoung Hwa Jang and co-workers from Scripps in their journal paper, is unlike any previously-reported natural antibiotic.

    The compound was extracted from Steptomyces bacteria that had been collected by Christopher Kauffman in Pacific Ocean sediments.

    Leader of the team of researchers, William Fenical, commented: "The real importance of this work is that anthracimycin has a new and unique chemical structure. The discovery of truly new chemical compounds is quite rare. This discovery adds to many previous discoveries that show that marine bacteria are genetically and chemically unique."

    Initial testing of the antibiotic compound has demonstrated it efficacy in attacking anthrax, a bacterium that has been used as a bioterrorism weapon. But it also showed significant activity against Staphylococcus aureus, the MRSA superbug.

    The discovery highlights the potential resource for new materials and compounds offered by the oceans, much of which remains unexplored.

    Simon Redfern
    BBC
    July 31, 2013

    http://www.bbc.co.uk/news/science-environment-23523507

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