Alleged Mafia boss John "Junior" Gotti is to go on trial in New York, as prosecutors launch a fresh bid to convict him.
Mr Gotti, 45, has been charged with conspiracy linked to cocaine trafficking and three gangland murders.
But the son of the late Gambino crime family boss denies the charges, saying he abandoned organised crime in 1999.
He has already served jail time for racketeering. Three later trials folded after juries failed to reach a verdict.
His father, John Gotti Senior, was nicknamed the "Teflon Don" because of his ability to escape justice.
He eventually died in prison in 2002 after being convicted of murder and racketeering.
Jury selection for the trial, to be held in a Manhattan court, will take place on Monday.
The charges, which follow an FBI investigation in Florida and New York, relate to murders in 1988, 1990 and 1991.
Mr Gotti faces life in prison if convicted. He has been in custody since his arrest in August 2008.
He was released from prison in 2005 having served more than six years for racketeering crimes including bribery, extortion, gambling and fraud.
In 2006, US prosecutors failed for a third time to convict him on more racketeering charges, after the jury was deadlocked.