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Painkiller '10 times more powerful' than current drugs on the market raising concerns

  1. kailey_elise
    Painkiller '10 times more powerful' than current drugs on the market raising concerns

    SALT LAKE CITY — Therapists working to get users off their addiction to prescription drugs are worried about a new super painkiller called Zohydro, which is now awaiting approval from the Food and Drug Administration.


    In the hands of licensed physicians serving patients with severe chronic pain, the extended-release pill would provide consistent 12-hour pain relief without having to pair it up with other medications. Though it could prove beneficial to patients with serious chronic pain, there is concern about the drug getting into the hands of abusers.

    Salt Lake City's Journey Healing Centers is among several rehabilitation facilities raising a red flag. Staffers there try to help people who are hooked on a wide range of drugs.

    Sean Hartley works with the Journey group now but remembers well his long-term addiction to painkillers. At age 17, OxyContin was his drug of choice.

    "It started with weekends and then just progressed and progressed," Hartley said. "At first a little pill would last me four days, and then suddenly I'm going through multiple pills per day."

    When the prescription drug got too expensive to buy on the street, Hartley switched to heroin. Through the teenage years into adulthood, his addiction tore him apart.

    "I was kicked out of my house. I've been in numerous rehabs. I was always getting into trouble and had run-ins with police. I had to drop out of college," Hartley said.

    At first, the OxyContin made Hartley feel powerful, as he described it. "There was no end. I could do anything. When I woke up, I couldn't function without it. I felt awful, nauseous, had aches and pains. Basically I was ‘detoxing.' Then I would put the pills back into my system and I was ready to go again."

    Hartley's long battle with drug abuse is why he and others at Journey worry about Zohydro. While beneficial to those patients, Journey clinical supervisor Michael Desjardins says the potent recipe could prove extremely risky in the hands of an abuser. Zohydro, he says, is going to be the first formulation of pure hydrocodone.

    "It's going to be 10 times more powerful than the current medications on the market, like Vicodin," Desjardins said. "It's going to increase the availability of the opiates, and I think that hydrocodone is quickly going to become the number one prescribed medication on the street today."

    Hartley agrees with his colleagues. He's been there and doesn't want to walk that street again.

    "I lived that life," he said. "Now it's time to move on, because I know what it did to me and I see it on a daily basis here at work, and what it's done to others."

    According to Hartley, the pills were a fake mirror. "I didn't know who I was," he said. "I couldn't sit with myself. But now I can sit with myself, and by that I mean in my own skin."

    Desjardins says if Zohydro is approved, it would be the first time pure hydrocodone is sold at the corner pharmacy.

    Ed Yeates || Wednesday, Jan. 25, 2012 2:32 p.m. MST

    http://www.deseretnews.com/article/...ent-drugs-on-the-market-raising-concerns.html

Comments

  1. kailey_elise
    New super painkiller Zohydro is more dangerously potent than Vicodin: narcs and docs

    New super painkiller Zohydro is more dangerously potent than Vicodin: narcs and docs

    [imgr=black]http://www.drugs-forum.com/forum/attachment.php?attachmentid=24441&stc=1&d=1327679113[/imgr]Drug maker to seek feds' approval for painkiller with 10 times the potentially addictive hydrocodone in Vicodin


    Drug companies are cooking up a potent new painkiller that New York narcs and addiction experts say could unleash the worst pill-popping plague since Oxycontin hit the streets.

    A single extended-release capsule will contain up to 10 times the amount of hydrocodone — a potentially addictive opiate — as the lowest-dose Vicodin pill.

    One manufacturer on the verge of asking the feds to approve a formulation it calls Zohydro says it’s “safer and more convenient” for treatment of chronic pain.

    But law enforcement officials and drug experts worry it will open a new front in the war against prescription drug abuse.

    “This has the potential to be Oxycontin all over again,” said Lewis Nelson, an emergency medicine doctor and toxicologist at NYU Langone Medical Center.

    Oxycontin is a time-released version of pure oxycodone that’s been blamed for turning the elderly, housewives and suburban teens into addicts.

    If Zohydro is approved, it would be the first time pure hydrocodone is sold at the corner pharmacy. Right now, the drug is only paired with acetaminophen under the brand name Vicodin, the second-most abused drug in the country.

    Bridget Brennan, the city’s special narcotics prosecutor, questions the effort to market a new pain pill against the backdrop of deadly pharmacy murders and soaring overdose numbers.

    “It’s hard to understand why we need yet another powerful opiate drug available,” she said. “I think the focus should be on non-addictive painkillers.”

    Pain-med cases make up 15% of her office’s workload, up from 3% five years ago. Painkiller poisoning cases have risen 20% in four years.

    When the Oxycontin problem spiraled out of control, the manufacturer created a new tamper-proof version that was supposed to prevent snorting and injecting.

    But it didn’t dampen demand: a 30mg pill of Oxycontin still sells for $20 to $30 on the street, according to Brennan’s office.

    The Drug Enforcement Administration has seen a three-fold increase in pharmaceutical investigations in the state since 2009, particularly on Long Island and Staten Island.

    Sen Chuck Schumer (D-New York) wrote to the FDA Sunday urging the agency not to approve the drug without stringent controls to prevent abuse.

    “It’s tremendously concerning that at the same time policy makers and law enforcement professionals are waging a war on the growing prescription drug crisis, new and more powerful super-drugs could well be on their way, flooding the market,” he said. “The FDA needs to grab the reins and slow down the stampede to introduce these powerful narcotics.”

    Wilbert Plummer, acting special agent in charge in New York, expects the new drug will wind up on his radar screen.

    Addicts build up tolerance to their usual drug of choice and “are always looking for the new pill,” he said. And there are always “rogue doctors” willing to write a prescription.

    “The addictive properties of this drug are going to be really strong,” said Dr. Jeffrey Parsons, a psychology professor and addiction expert at Hunter College.

    “You are going to have little old ladies who are in significant pain who get hooked on this and start using it even when they don’t need it.”

    Zogenix, which developed Zohydro, plans to submit an application to the FDA sometime after March, and it could be available early next year.

    It said a pure hydrocodone pill is needed by patients with round-the-clock pain because the acetaminophen in Vicodin can be toxic to the liver.

    While admitting no pill is abuse-proof, it argued that Zohydro will be more tightly regulated than Vicodin and refills will be harder to get.

    But Matthew Neebe, director of Brentwood Mental Health Programs for the drug-treatment center Phoenix House, said the ingenuity of an addict or dealer cannot be underestimated.

    “There are a lots of creative people out there who will get their hands on these pills,” he said.

    Joe Kemp & Tracy Connor || Published: Saturday, January 7, 2012, 12:44 PM & Updated: Monday, January 9, 2012, 9:01 AM

    http://www.nydailynews.com/life-sty...rts-article-1.1002241?localLinksEnabled=false
  2. scartissue_68
    Re: Painkiller '10 times more powerful' than current drugs on the market raising conc

    At least there will be an option for not continuing to poison users of hydrocodone with Acetaminophen. But, I'm guessing all versions of this med will be Schedule II. Why? Higher abuse potential without the danger of liver damage due to APAP? Sounds like the lunacy of the FDA/DEA Pharmacological Complex to me.

    Example: I asked my PCP to give me Codeine WITHOUT the APAP (Schedule III). He agree and wrote the script, but the Pharmacy had to order it special and when it was filled, the prescription for the same amount of Codeine without APAP was a Schedule II. (WTF?) Now, in order to get my "dangerous fix" of 60mg of Codeine/day, I have to get a written script for every refill, spend extra time and gas money to play by the "rules" and it costs me almost 4X as much for 60 pills.

    I'm assuming that the ER Zohydro will be patented and probably follow the Oxycontin OC to OP model (tough to deconstruct for recreational purposes) and thus be very expensive until years from now when it goes generic.

    If you drill down, this "10 times more potent" claim relates only to the ER version, which I'm guessing will have something like 75 MG dosing for a 12 hour duration. According to the manufacturer's website, the drug itself is still just Hydrocodone. It's not some new, super-drug as the article would lead us to believe.

    Thanks for the news Kailey.
  3. scartissue_68
    Re: Painkiller '10 times more powerful' than current drugs on the market raising conc

    Looks like my info is old news, now. Kailey was all over it.

    Go safe fellow travelers.
  4. war209
    Re: Painkiller '10 times more powerful' than current drugs on the market raising conc

    why can't the drug company make pain killers that do not damge you liver or kidney .

    They are still making these pain killers that do damage to your body.
  5. Ghetto_Chem
    Re: Painkiller '10 times more powerful' than current drugs on the market raising conc

    War209- Most painkillers that actually work reasonably well are opioid-related substances, unfortunately one side effect to alot of opiates is damage to the liver and kidneys.

    This must be the drug that swims friend made a thread about a little while back. Alot of people viewed it but no one seemed interested in responding. This new pharmaceutical formula will most definitely be another pill, addicts and recreational users, will want to get their hands on. Personally he thinks this is a much better alternative to oxycodone in slow release formulas, less abuse potential and alot of people find hydrocodone great for pain management.

    Peace
  6. war209
    Re: Painkiller '10 times more powerful' than current drugs on the market raising conc

    Yes but why can't they make the pain killers / opioid that do not do damage ?
  7. Auntie
    Re: Painkiller '10 times more powerful' than current drugs on the market raising conc

    Because to have any effect on the body, drugs have to modify how it functions. When it can be done without any other process than the target being altered it's great, but also an extremely rare luck.
  8. psyche
    Re: Painkiller '10 times more powerful' than current drugs on the market raising conc

    Where did you get this? Opioids generally don't damage liver or kidneys. Acetaminophen does, an additive to a multiple codeine preparations if that's what you mean.

    Mu- and delta-opioid receptor binding, which is how opioids have their effect, is not related to kidney or liver problems. It's a relatively harmless, natural-like process to inhibit pain signals.
  9. Docta
    Re: Painkiller '10 times more powerful' than current drugs on the market raising conc

    An excellent question, kinda makes ya wonder why no one's asking that question.

    Who'd wont to in this kind of climate it's almost un commercial, in this case no good deed goes unpunished.

    Answer, just look at the head lines.

    Just look at the media witch hunt, "10 times more powerful" what an absolute crock of shit, Zogenix make pharmaceutical delivery systems they don't make drugs.
    ZX002 or what ever catchy name it has now is a new oral capsule controlled-release formulation of hydrocodone bitartrate without Acetaminophen.

    What's on the pivotal Phase 3 efficacy study (Study 801) clinical trials is Elan Pharma International Limited’s Spheroidal Oral Drug Absorption System, or SODAS Technology.

    The system will allow 10 times the dose in one administration every 12 hours, it's still the same hydrocodone bitartrate used in Vicodin but with out the APAP loading side effects. The delivery system a control against over dosing.

    Zohydro (ZX002) is a drug designed for patients on full time opioid medication but the media doesn't understand the needs of patient safety, don't give a shit about lessening liver damage side effects of long tern chronic pain management.

    It's this kind of media bias and misinformation that sites like DF fight with it's drug wiki,

    It's like the Salem witch trials, the townsfolk running around with pitchforks and lighted torches.
  10. scartissue_68
    Re: Painkiller '10 times more powerful' than current drugs on the market raising conc

    "Salem Witch Trials", Great analogy Dacta. Concerning the "extra" ingredients the media never reports in drugs with abuse potential, I believe the idea was originally potentiation. Caffeine, APAP, Aspirin, etc. have all been included in many immediate release "pain" pills.

    The media may not care about the style of reporting we're discussing, but Personal Injury Lawyers are starting to use the media via advertising, trolling for victims of Acetaminophen Poisoning. Recently, commercials on 24/7 news networks can be seen (called per inquiry ads, because they are billed to the advertisers based on consumer response). The spots have a big graphic, headlined with 1-800-BAD DRUG and includes all users of Vicodin, Percocet, Codeine with APAP, etc. who have suffered liver damage. If even one multimillion dollar class-action case is settled in favor of those with damaged livers, we'll start to see IR opiate analgesics with no APAP or other dangerous potentiaters. Let hope this doesn't lead to even stricter prescribing guidelines and more DEA intervention. As I posted earlier in this thread, 30mg of Codeine without APAP is currently sold, but is a Schedule II. T-3 (30mg with APAP) is Schedule III. (?)
  11. war209
    Re: Painkiller '10 times more powerful' than current drugs on the market raising conc

    I'm sorry I do not understand

    Are you saying there is this movement in media now that is starting to get worked up over pain killers now. A media sensation that there is this pain killer epidemic abuse in the US .

    The media loves sensation it makes the headlines . What more of sensation of headlines saying Americans are hooked on pain killers or teens in school are getting high of pain meds.
  12. scartissue_68
    Re: Painkiller '10 times more powerful' than current drugs on the market raising conc

    There were two separate concepts relating to the same topic in my post.

    The media will always take stories with strife, death and personal tragedy as fodder for selling us sensationalized stories. Unfortunately, drug users, dealers and illegal manufacturers/growers fit in that category.

    The point I was making about 1-800-BAD-Drug being advertised in the media is that the Personal Injury Lawyers are using the Liver damage caused by Acetaminophen in an attempt to build class action law suites. They are simply using pain drugs with APAP as a way to communicate to viewers that they may have been damaged, if they took too many T-3's. This could be a good thing for getting APAP and other "poteniator's" out of common pain pills, but may have a negative effect on doctors being even more unwilling to prescribe Opiates for pain relief. Drug Companies and Doctors will be the prime targets of the PI attorneys for the litigation against APAP.

    Hope that helped explain what I was trying to say.

    Go Safe.
  13. Ghetto_Chem
    Re: Painkiller '10 times more powerful' than current drugs on the market raising conc

    To Psyche,

    Don't really know much about kidney and liver damage, just heard it around. Heres a ref to support the claim,

    Liver and Kidney toxicity in chronic use of opioids: An Experimental Long-Term Treatment Model; SEBNEM ATICI, ISMAIL CINEL, LEYLA CINEL, NURCAN DORUK,
    GULCIN ESKANDARI and UGUR ORAL; Department of Anesthesiology and Reanimation, Department of Pathology, Department of Biochemistry, Mersin University, School of Medicine, Mersin, Turkey

    In that ref they found that rats did take some damage, don't know much about that terminology but things like "centrolobular congestion and focal necrosis in the liver" don't sound too great lol.

    Swims friend has personally used opiates for the past 5 years almost daily and has definitely noticed pains in his kidneys and liver area, just another motivation to get off this shit.

    Peace
  14. talltom
    Re: Painkiller '10 times more powerful' than current drugs on the market raising conc

    I would think if this is approved it would be a schedule II drug like codeine without acetaminophen or some other additive. As others on the thread have pointed out, this means you have to see your doctor and get a separate prescription each time you get a refill. This is inconvenient, but it may cut down on abuse.

    And yes, the media are overhyping the dangers of prescription pain medication. I posted an article about this on the "Crisis in Pain Medication" thread in the Drug Policy Reform section. (It's a little confusing because it was automerged with an NPR transcript on the same subject I had posted earlier in that thread.)
  15. VagabondWraith
    Re: Painkiller '10 times more powerful' than current drugs on the market raising conc

    I hate to rant, but on media/law enforcement dissemination of misinformation, I get exponentially pissed off. This new drug, if approved, will fill a very important niche which is currently not filled, IS sorely needed, and will widen the spectrum of flexibility of treatment for patients of CP, such as myself. This includes the availability of medical cannabis, and other such treatments, but I digress.

    As others have pointed out, the "10 times the strength of Vicodin" hype is a garden growing load of BS. It's the same dose, but spread out over 12 hours, and one can dose twice a day as opposed to 4-6 times. The MOST important feature however, is the exclusion of the NSAID, which over the long term, can cause a *lot* of damage, especially to a patient with type 1 diabetes, such as myself. The acetaminophen/paracetamol is bad enough, but many people cannot take aspirin (fatal allergy, or salicylate intolerance), and ibuprofen over the long term can harm the kidneys and the pancreas (horrible by itself, but worse for patients with either kind of diabetes). Also, a lot of people don't need or want oxycodone, or hydromorphone, morphine, fentanyl, et al, but if they want hydrocodone or codeine, are forced to take an NSAID.

    I truly hope this new drug (which isn't a NEW creation, just in its formulation/time release formula), gets FDA approval as it *will* help a lot of people. To exercise prior restraint because of a possibility of illicit use is like saying "We are going to deny you a legal course for treatment, because some people might decide to act like a$$holes, and will make our jobs harder". Moreover, to act in this way is to do harm by inaction/improper action, which is in direct contradiction to the Hippocratic oath, which all doctors must take in order to get license to practice. This IS a decision for doctors to make, NOT any government political/law enforcement agency, or media fueled misinformation hawkers.
  16. draz3
    Re: Painkiller '10 times more powerful' than current drugs on the market raising conc

    Scarface,

    Good point about the bloodsucking lawyers who advertise about drugs with APAP causing cirrhosis and fatty liver. There are plenty of schedule two products without APAP-Opana, Dilaudid, Oxycontin, Codeine, Morphine, etc. The media just loves sensationalizing this stuff. I never saw an article when Opana ER 40mg came out and that is a lot stronger than Zohydro is going to be.
  17. teletrooper
    Re: Painkiller '10 times more powerful' than current drugs on the market raising conc

    The irony of the OC to OP is that a domestic snimal can still chew a pill and get feline euphoria but actual pain patients ( who have no rights) shit out like 25% or something ( someone tested the little balls of shitty green...) cause the op's come out looking like they went in. Out of 100 patients, 98 said OP sucked compared for pain control.
  18. teletrooper
    Re: Painkiller '10 times more powerful' than current drugs on the market raising conc

    I actually am glad that the absurd toxicity of APAP is discussed. In the old days my parakeet took percocet and drank beer with no idea that is pickling ones liver in sulfuric acid
  19. usually0
    Re: Painkiller '10 times more powerful' than current drugs on the market raising conc

    So, Zohydro is an extended release hydrocodeine? What's the difference?

    What's the fuss? Fentanyl already exists and it's much more potent than oxycodeine.
  20. Hollow Hippie
    Re: Painkiller '10 times more powerful' than current drugs on the market raising conc

    More scare news from the good ol' American media machine. This is basically the OxyContin equivalent to Percocet. A lot of opioids come in extended release forms (morphine, oxycodone, etc.) so why is it so bad for hydrocodone to be the same? Maybe these people should start giving a shit about actual pain patients that need these sort of things.
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