Prescription Artane (trihexyphenidyl) a Drug of Abuse?

By Boca Bitch · Jul 29, 2009 · Updated Jul 29, 2009 · ·
  1. Boca Bitch
    According to an article in the New York Times:

    Trihexyphenidyl an antimuscarinic typically prescribed for Parkinson's disease can provide one with a sense of "euphoria and well being" when taken in larger doses. There's been a dramatic rise in its abuse with Iraqi soldiers and police.

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  1. chillinwill
    Please post the full article here on DF. Instructions on how to do this can be found in the main drug news forum. The reason being is that links die over time but if the article text is posted on here, it will remain over time.
  2. Politicalchalk
    trihexiphenidyl in the same class as carisoprodol ("somadril" aka "soma")?? Nope. Carisoprodol is a muscle relaxant that is a carbamate derivative (ie: prodrug for meprobamate). Artane, or trihexiphenidyl, plays with muscarinic receptors. Carisoprodol effects GABA more than anything.

    Swim calls bullshit. Of course, anything can CAN be abused will be at some point (like michael jackson's propofol-mobile). The doctor also notes that use varies, with some only taking it under time of heightened stress.

    Addicition just seems too quick a word to throw out . Artane: off-label anxiolytic?
  3. Boca Bitch
    The only FDA indication is treatment for Parkinson's, usually adjunct to levodopa or another anticholinergic agent. Off-label use is pretty much confined to treating the extrapyramidal side-effects of some antipsychotics. It's being looked into for treatment of other forms of dyskinesias, HD, and dystonia.

    So it's pretty much used for maintaining control over voluntary movement and restricting involuntary movements.

    To consider a psychotropic with these indications as an anxiolytic is as much a surprise to me as it is to you.
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