1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.

Prescription weight-loss medication helps with opiate addiction recovery

Researchers from The University of Texas Medical Branch at Galveston have confirmed that a prescription weight-loss pill decreases the urge to use...
  1. DroppedYourPocket
    IMG_0654.jpg Image: Arena PharmaceuticalsResearchers from The University of Texas Medical Branch at Galveston have confirmed that a prescription weight-loss pill decreases the urge to use opiates such as oxycodone.

    In a study published in ACS Chemical Neuroscience, the researchers led by UTMB scientist Kathryn Cunningham found that the drug, lorcaserin, reduced the use and craving for the opioid oxycodone in preclinical studies. Cunningham is director of UTMB's Center for Addiction Research and a professor in the department of Pharmacology and Toxicology.

    Opiate abuse is a major public health problem and according to the U.S. Centers for Disease Control and Prevention, the number of deaths from prescription opiate overdose in America has quadrupled since 1999. High relapse rates and too few people remaining in treatment programs long enough for it to really benefit them continues to pose major challenges in treatment for the misuse of prescription opiates such as oxycodone and illegal opiates such as heroin.

    Most of the treatments available to reduce opiate misuse work by occupying opioid receptors in the brain. If someone were to take an opiate while on these treatments, they would not feel the signature euphoria as strongly. However, a person's drug-taking environment is a powerful cue that can condition someone to anticipate the experience of taking of the drug; this is called cue reactivity. People who have tried the currently available medications often relapse when they are around the people, places or paraphernalia that they associate with opiate use.

    Lorcaserin, prescribed for weight loss, alters the serotonin system by changing chemical signals that affect satiety, the sensation of fullness. Serotonin regulates the brain circuitry involved in drug reward and cue reactivity, particularly though activating serotonin 2C receptors. Previous work by Cunningham and her team have shown that lorcaserin decreases how many times rats will complete a simple task to earn a dose of cocaine. However, much less is known about the involvement of the serotonin 2C receptors in altering how opiates feel rewarding for the user.

    The researchers trained rats to self-administer oxycodone while exposed to specific lights and sounds that create a drug-taking environment. Once the rats were used to regularly consuming oxycodone, they went through a period where no oxycodone was available to them. The researchers then gave lorcaserin to some of the rats while others were given a placebo and placed them in the drug-associated environment. At this point, oxycodone was again made available to the rats. The lorcaserin rats self-administered less oxycodone and reacted less strongly to cues associated with taking the drug. In order to show that this effect was attributed to the lorcaserin, a group of rats was given lorcaserin as well as a drug that blocks the serotonin 2C receptors -- thus cancelling out the effect of the lorcaserin -- those rats tried very hard to get oxycodone.

    "The effectiveness of lorcaserin in reducing oxycodone seeking and craving highlights the therapeutic potential for lorcaserin in the treatment of opioid use disorder," said Cunningham. "We plan more studies to better understand how drugs like lorcaserin can help us stem the tide of addiction in America."

    Original Source

    Written by: Unspecified, Mar 24, 2017, Prescription weight-loss medication helps with opiate addiction recovery, study confirms, University of Texas Medical Branch at Galveston


  1. TheCountess
    Those lucky little rats! *smiles* I've got the funniest image in my head right now imagining this study.

    Sounds like it could be a step in the right direction. Would love to hear other opinions on this research.

    1. DroppedYourPocket
      Well, I heard there were a lot of bad side effects that come with this drug so I don't how good it would actually be.

      I still think it's fucking cool though. People out here fighting the good fight.
  2. Andy54
    Wow loose weight and get the TRAMADOL MONKEY off my back would be great. Do you think the FDH will pass it soon?
    1. DroppedYourPocket
      Honestly, I don't know. I know it was rejected by the FDA in 2010 but eventually passed in 2012. So I guess if a doctor wants to try it with a patient, it's up to him. Not sure how all that works.
  3. Dr. Amapola
    Whatever it is, it can't help too much because that'd put all of the Dr. Feel Goods and Methadone Clinics out of business. Methadone alone is a multi-billion dollar per year industry. If anything allows people to get off of that stuff quickly and safely, you can bet your balls to a barn dance that every step will be taken to ensure it's as difficult as humanly possible for an opiate-dependent person to get it.

    I hate to be the pessimist throwing water on such a young flame, but that's just me. I became opiate-dependent in 2007; after kicking heroin at just 19 I was led by some by-the-book type physicians into a "harm reduction program"---the local methadone clinic. I had kicked for the Nth time and they told me it was, "a temporary treatment that will stop cravings for drugs, and thus help you get on your feet again."

    I was 19 years old when a nurse who had been working with methadone since 1978 told me with a smile, "If you follow the rules here and work the program you should be out of here in six to eight months."
    While I'm not a medical professional, even I knew that stunk like bullshit. However with my life in ruins and ultimatums at my head like a gun, I all-but had to drink the methadone and go along with the program...and I did.

    Now I'm 30 years old and I can't get off of methadone.

    What's the moral of the story? The medical industry is full of people who want your money. For each person who becomes dependent on their medicine, they have another customer. So whether you're a patient at a methadone clinic or you just have a bad recurring rash, you can bet your last dollar that somebody somewhere is looking to capitalize on your sickness.
      perro-salchicha614 likes this.
  4. Dmax72
    I was using heroin and alcohol daily. Someone suggested I try methamphetamine intranasally. Since I started using meth I have not had the first thought of using heroin or consuming alcohol. It has been 8 weeks since I used H or drank. I personally know several people this has worked for. I consume about a Graham cracker every 5 days. Many will say that it is trading one evil for another, maybe so, but I have watched my bank account steady grow instead of being broke 3 days after payday.
    1. California.sweet.mommy
      I so when u used meth instead of heroin didn't u withdraw pretty bad the first few days?
    2. DroppedYourPocket
      I actually know a few people who have used meth to get off heroin. Unfortunately, for them, it was trading one evil for another. In the end, nothing was solved.
      perro-salchicha614 likes this.
    3. Dmax72
      Very very mild withdrawal symptoms.. Was still able to work and function. ROA was IV. A couple Geese would be gone in less than 2 days. I tried kratom and that did absolutely nothing... That has got to be a placebo effect.
To make a comment simply sign up and become a member!