Red Wine Molecule Helps Mice Live Longer (Resveratrol)

By ~lostgurl~ · Nov 2, 2006 · ·
  1. ~lostgurl~
    Red Wine Molecule Helps Mice Live Longer

    Patricia Reaney

    A compound found in red wine and grapes can extend the life-span of obese mice and help them enjoy a healthier old age, scientists said.

    The molecule known as resveratrol not only enabled the mice to live longer than other overweight rodents, it also reduced the negative health effects of eating a high-calorie diet.

    Resveratrol has been shown to have same effect in studies on yeast, flies and worms but the scientists said their research is the first to show it works in mammals.

    "It is possible to find a molecule that activates the body's natural defenses against aging. You can use it to enhance the health of a mouse or mammal. That is unprecedented," said David Sinclair, of Harvard Medical School in Boston, Massachusetts.

    He added that the study, reported in the journal Nature, is proof of the principle that it works in mammals. But the real test will be to develop formulations or find other molecules to treat age-related illnesses such as diabetes, Alzheimer's, heart disease and cancer in humans.

    "The goal here is within the next few years to know it is possible to treat diseases in man," he told Reuters.

    Health Benefits

    Researchers already know that restricting calories can prolong life in mice and other organisms. Resveratrol seems to mimic the beneficial effects of eating less without the hassle of dieting.

    Sinclair and an international team of scientists analysed the impact of molecule by studying three groups of middle-aged mice. One group ate a standard diet. The second was fed a high-calorie diet and the third had the same diet but were given supplements of resveratrol.

    Eight weeks after starting the study, the scientists noticed a difference between the two high-calorie groups. By the time the mice were 114 weeks old, 58 percent in the high-calorie group had died, compared to 42 percent in the other groups.

    "After six months, resveratrol essentially prevented most of the negative effects of the high-calorie diet in mice," said Rafael de Cabo, a co-author of the study from the National Institute on Aging in the United States.

    The study is continuing but so far the compound has extended the life-span in the high-calorie mice by about 10-20 percent.

    "There is no question that we are seeing increased longevity," said Sinclair.

    In addition to increasing survival, the compound reduced the negative effects of being obese so the mice treated with resveratrol lived as long as the lean mice.

    They had healthier heart and liver tissue, decreased blood sugar levels, better insulin sensitivity and were more active than the other rodents.

    When the scientists looked at the genetic level, to see which genes in the mice were switched on or off, they found the molecule had changed the gene expression pattern of the obese mice toward that of a lean mouse.

    The next step is to understand how the compound works.

    Sinclair and his colleagues believe a key component could be the SIRT1 gene which is thought to be linked to life-span extension.

    Sirtris Pharmaceuticals, a therapeutics company co-founded by Sinclair, has started a trial of a proprietary formulation of resveratrol in patients with Type 2 diabetes.

    "The real bang will be if somebody proves this is going to work in people," Sinclair added.,,13440-6512157,00.html
    ©2006 Xtra Limited

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  1. tayo
    My Robot just ordered 50 grams of 50% resveratrol from an online supplier and will recieve it soon and will be using as much as the rats used in mg/kg per body weight (but taking into account human metabolism) for a few days, then cut back to lower doses around 1-2 grams.
    Robot is looking to use this as a weightlifting supplement and to support overall health.
    The only problem with a 50% trans-resveratrol product is that the other 50% could contain up to ~15% emodin, which had a laxative and diuretic effect.
    Newer products are up to 98%-99% trans-resveratrol.

    Some additions to this article are that
    ~trans-resveratrol seems to be the more bioactive form of resveratrol, as opposed to the isomer cis-resveratrol.
    *resveratrol increases the number of mitochondria in muscle tissue
    *-resveratrol decreases insulin sensitivity (more mitochondria, less energy needed for energy conversion through ATP)
    *-mitochondria are responsible for apoptosis which is a programmed cell death, for instance cancer cells, maybe fat cells too! Mitochondria are regulators of cells.
    *lowers total cholesterol
    *half-life appears to be ~1.5 hours
    *little evidence of toxicity
    *increases potency of some antiretroviral drugs
    *many online accounts report increased energy, at least in the "500 club" meaning 500mg of resveratrol or more
    *it is a phytoalexin produced by plants in response to fungus, it is anti-fungal
    *it is found in some berries, nuts, pine, red grape skins
    *most of the extracts are coming from Japanese Knotweed because it is more concentrated and more cost-effective

    This is very exciting for my Robot, here..just read this...

    If you're interested this article is very good, .

    And if you'd like to watch these harvard science junkies talk about it in the first third of a PBS TV show click here...
  2. Corksil

    Thanks so much for the links and the information. This is why SWIM enjoys reading on forums like this, because he eventually stumbles across something which he might be able to directly benefit from, and apply to his own life to [possibly] better it.

    Very excellent stuff, SWIM has read the corresponding linked wiki on it. He will look for trans-resveratrol on the internet after further reading...
  3. Hey :-)
    New pill to fight ageing: Could drug be secret to a longer life?

    A PILL that prevents ageing and keeps people healthier for longer is a step closer, scientists claimed last night.

    [IMGL=''white''][/IMGL]The breakthrough paves the way for a supplement which could be added to a normal diet to rejuvenate the body.

    As people live longer the body becomes less able to repair itself, making it age and become more prone to disease and illness.

    As our scientific knowledge advances, researchers have become engaged in a race to delay the onset of age-related diseases by discovering an “elixir of life” drug.

    Now a team at the National Institute on Ageing at the National Institutes of Health in the US has discovered a “promising strategy” to arrest ageing.

    They have found that activating a specific protein not only extends lifespan, it also delays the onset of age-related metabolic conditions such as heart disease and diabetes, and improves general health by lowering cholesterol and inflammation.

    The discovery centres on a protein called SIRT1. Drugs that increase its activity in the body have been found to slow the onset of ageing and delay age-related diseases in several animal models. Lead researcher Dr Rafael de Cabo said: “Here, we show for the first time that a synthetic SIRT1 activator extends lifespan and improves healthspan of mice fed a standard diet.”

    He added: “We are hoping in the long term to translate some of these findings into humans.

    “That is the ultimate goal. I think rather than to extend lifespan it would be much better to postpone age- related diseases.

    [IMGR=''white''][/IMGR]“If we could eliminate some of those, that would be fantastic or to postpone the onset. If we could delay the onset of Alzheimer’s disease or diabetes say for 10 or even 15 years, the life of the pop*ulation would be hugely improved. Extending healthy life is the ultimate goal.” In 2011, Dr de Cabo discovered a family of drugs based on resveratrol, the “miracle ingredient” in red wine which is credited with inhibiting the development of cancer and heart disease.

    He showed the drugs could activate SIRT1 and their potency would give them the equivalent health benefits of 8,000 bottles of wine.

    Mice given the drugs did not gain an ounce of weight despite being fed fatty foods, and blood tests suggested they were protected against diabetes. They also showed improved stamina.

    At the time, Dr de Cabo said: “To me, the most tantalising thing about the findings are the health benefits.

    “I don’t care much about living five years longer as long as I live what I am supposed to live completely healthy.”

    The findings, which appear online in the journal Cell Reports, point to a potentially promising strategy for improving health and longevity. Animals were fed a standard diet supplemented with the research team’s new synthetic drug to activate SIRT1.

    The researchers found that the drug significantly extended the average lifespan of mice by 8.8 per cent.

    Those fed the drug were also lighter and slimmer with better muscle function and co-ordination throughout their lives.

    Further studies showed that the supplement led to a heart-protective lowering of harmful cholesterol and improved insulin sensitivity which could help prevent diabetes.

    Anti-inflammatory effects were also seen in various tissues. This is important because chronic low-level inflammation is believed to contribute to ageing and age-related diseases.

    By Jo Willey
    Photographs Getty Images
    Friday 28 February 2014
    Express News
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