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Schizophrenia Drug Bitopertin Fails in Late-Stage Trials: Roche Holding AG

By Hey :-), Jan 21, 2014 | | |
  1. Hey :-)
    Swiss pharmaceutical major Roche informed Tuesday that experimental schizophrenia drug bitopertin failed in two late-stage trials.

    The results found from the drug use could not reduce negative symptoms among patients. The company will continue with third late-stage study.

    Bitopertin was used with along with antipsychotics to reduce symptoms of schizophrenia. Bitopertin could have been the first drug in new class of treatment for the ailment. As per official communication from Roche, the phase III trials could not offer significant improvement after 24 week treatment.

    The company is working on several projects in neuroscience which include drug development for multiple sclerosis, schizophrenia and Alzheimer’s disease.

    The impact on stock could be minimal as market analysts were not having big expectations from bitopertin. The company statement said that the future course will be decided after considering the data from ongoing studies.

    Bitopertin is a glycine transporter type 1 (GlyT1) inhibitor. It works by increasing the level of the neurotransmitter glycine by inhibiting its reuptake from the synaptic cleft.

    Schizophrenia impacts 26 million people across the world. University of Birmingham research team has also been involved in the research and development of the drug for schizophrenia.

    By Naledi Nyamambi
    Tuesday 21 January 2014
    News Tonight Africa


  1. C11H15
    Very interesting,
    This brings some research conducted in the 90's to light. There were several studies that supported and postulated the relation and mechanism behind glycine modulation of NMDA receptor sub-types in schizophrenic pathology. Not just acknowledging the studies but applying it in a real world application.

    Heresco-Levy, U., Javitt, D.C., Ermilov, M., Mordel, C., Silipo, G., Lichenstein, M. (1999). Efficacy of High-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Archive of General Psychiatry. 56(1):29-36. doi:10.1001/archpsyc.56.1.29.
    Javitt, D.C. (2002). Glycine modulators in schizophrenia. Current Opinion in Investigational Drugs. 3(7):1067-1072.
    Javitt, D.C., Zylberman, L., Zukin, S.R., Heresco-Levy, U., Lindenmayer, JP. (1994). The American Journal of Psychiatry. 151(8):1234-1236.
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