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Stronger cannabis increases the risk of memory loss

By Balzafire, Oct 1, 2010 | | |
Rating:
3.5/5,
  1. Balzafire
    People who smoke strong strains of cannabis are at greater risk of memory loss than those who smoke other types of the drug, according to new research.

    Experts writing in the British Journal of Psychiatry called for cannabis users to be made aware of the risks associated with some strains of cannabis, and encouraged to use varieties with higher levels of the extract cannabidiol instead.

    Cannabidiol and THC are two major constituents of cannabis. THC is the main psychoactive ingredient that makes users feel "stoned", and produces psychotic-like symptoms such as delusions and paranoia.

    In contrast, cannabidiol does not induce these symptoms and may counteract the effects of THC. Levels of cannabidiol in cannabis can range from almost none to up to 40 per cent.

    University College London researchers found that people smoking cannabis with a low cannabidiol content performed much worse on memory tests when they were intoxicated. In contrast, those smoking cannabis high in cannabidiol performed just as well on the tests when they were intoxicated.


    By Lyndsay Moss
    01 October 2010
    http://news.scotsman.com/news/Stronger-cannabis-increases-the-risk.6559743.jp

Comments

  1. veritas.socal
    so, in swib's opinion, would that be the more indica dominant strains, with thier painkilling and sedative effects? just wondering. swims memory sometimes sucks, but is sometimes perfect.
  2. Balzafire
    Swim has no idea. If he smokes cannabis, he spends the next few hours peeping out his windows.
  3. FreeBliss
    yea swim gets delusional and phycotic when he smokes weed sometimes. Swim doesn't think it was always that way but now a days it is.

    so maybe those times when swim actually has a ok high and doesn't get paranoid are times when the weed is high in that cannabinol shit or what ever you call it lol

    Hell give swim a bowl of that cannabinol shit and he will be ok probaly.

    If there was a way someone could separate that out and do experiments on it that would be sweet, it could probably help people some how without making them hyper aware and paranoid

    I bet that stuff has some gaba effects since it counters the paranoid effects but thats just my hypothosis. I bet if swiy took some gaba supplement and thc he would not have the negative effects.
  4. snapper
    SWIM is fine with living with memory loss - SWIM is used to it and thinks that the high is worth the effort .How the hell does one reliably control for cannibinol content anyways?... Plants vary even with the time the flowers ferment, not to mention strain and genetics. SWIM finds most weed is very similar and has never been able to distinguish strains very well or appreciating their subtle differences.
  5. FreeBliss
    There's definitely a difference from the sativa commercial weed and indica hydro, if its properly dried and cured and full of white sticky resin wow that is the bomb
  6. Euthanatos93420
    I think the issue here is higher levels of THC consumption among those who have the resources to afford it.

    Comparing two groups who smoke the same amount of plant matter between commercial mexipress and something grown with skill in a hydro setup isn't even a fair basis for making the headline statement.

    Of course one group has more side effects. They've consumed more THC and that is the cause of side effects not the potency of a strain.

    More propaganstic dumbshit yak without any reference to the supposed study that gives them the liberty to go bawwing about.
  7. veritas.socal
    That was swims point, if one had access to medicinal grade cannabis, as swim does( they even do deliveries, legally) would the higher cbd content be in the indica dominant( master yoda, OG Kush), hybrids(sour kush, headband) or sativa dominant( green crack, urban poison).
    Thanx for the input, and its for info only, not to back up a pointless study about... Wait, what was swim saying?
  8. Euthanatos93420
  9. Terrapinzflyer
    Neither really- both indicas and sativas have been bred for decades for high THC low CBD content. Medical growers focussing on high CBD are really going back to the drawing board on this- often going back to the strains from 20 years ago that are the great grandparents of many modern strains- and then selectively breeding for CBD. There is also a new frontier of growers travelling to india, africa, nepal, pakistan, south america... collecting strains that have not been so selectively bred.

    A good medical marijuana dispensary or collective in CA should be able to put one in touch with a high CBD / low THC strain - they are becoming more available and those that really focus on sick patients (rather then using medical marijuana as an end run around prohibition) should have these available.


    A few of the related threads in the news forum:
    Directions in medical marijuana research

    Project CBD: Marijuana Specialists Plan To Study New Strains

    Is Cutting-Edge Marijuana Lab the Future of Legitimate Pot?

    New Medi-Pot Strips Away the Buzz

    Not just a high

    Form of medical marijuana won't get you high, but it's creating a buzz

    It’s lack of balance that makes skunk cannabis do harm

    New Analysis Says Cannabis Breeders Should Grow for Safety As Well As Potency
  10. Balzafire
    Key ingredient staves off marijuana memory loss

    Cannabis composition determines effects on the brain.

    [imgl=white]http://www.drugs-forum.com/forum/attachment.php?attachmentid=17054&stc=1&d=1285947419[/imgl]Smoking cannabis has long been associated with poor short-term memory, but a study now suggests that the strain of cannabis makes all the difference. In a test of short-term memory skills, only users of 'skunk'-type strains exhibited impaired recall when intoxicated, whereas people who smoked hashish or herbal cannabis blends performed equally well whether they were stoned or sober.

    The findings suggest that an ingredient more plentiful in some types of marijuana than in others may help to reduce the memory loss that some users suffer.

    The key difference between the types of cannabis is the ratio of two chemicals found in all strains. Tetrahydrocannabinol (THC) is the primary active ingredient, and is responsible for the effects associated with the classic 'high', including euphoria and giddiness but also anxiety and paranoia. The second chemical, cannabidiol, has more calming effects, and brain-imaging studies have shown that it can block the psychosis-inducing effects of THC2. Skunk-type strains of cannabis contain a higher ratio of THC to cannabidiol than do hashish or herbal types.

    Valerie Curran, a psychopharmacologist from University College London who led the latest study, says that if habitual users must partake they should be encouraged to use strains with higher levels of cannabidiol, rather than using skunk. She also argues that studying cannabidiol could provide insight into the mechanics of memory formation, and that it may have therapeutic benefits for disorders involving memory deficits. The findings are published in the British Journal of Psychiatry today1.

    Cannabis use has increased in recent years — almost as many 16–24-year-olds in the United Kingdom have tried as haven't, according to the 2008 report Statistics on Drug Misuse by the National Health Service — and concerns have been raised that increased levels of THC in 'skunk' varieties owing to agressive plant breeding over the past decade are responsible for a rise in the number of young users displaying mild-to-severe cognitive impairment. However, links to a possible higher incidence and earlier onset of psychotic conditions such as schizophrenia remain controversial, as do associations with long-term psychological problems. Researchers suspect any effects of the drug on mental health could be a result of an increased ratio of THC to cannabidiol in cannabis, because levels of cannabidiol have not kept pace with rising THC concentrations.

    Total recall

    To test this hypothesis, Curran and her colleagues travelled to the homes of 134 volunteers, where the subjects got high on their own supply before completing a battery of psychological tests designed to measure anxiety, memory recall and other factors such as verbal fluency when both sober and stoned. The researchers then took a portion of the stash back to their laboratory to test how much THC and cannabidiol it contained.

    The subjects were divided into groups of high (samples containing more than 0.75% cannabidiol) and low (less than 0.14%) cannabidiol exposure, and the data were filtered so that their THC levels were constant. Analysis showed that participants who had smoked cannabis low in cannabidiol were significantly worse at recalling text than they were when not intoxicated. Those who smoked cannabis high in cannabidiol showed no such impairment.

    The results suggest that cannabidiol can mitigate THC's interference with memory formation. This is the first study in human to show such effects. One previous study, led by Aaron Ilan, a cognitive neuroscientist at the San Francisco Brain Research Institute in California, failed to find variations in cognitive effects with varying concentrations of cannabidiol3.

    Ilan attributes the positive finding of Curran and her team to their more powerful methodology in analysing subjects' own smoking preferences. In the United States, government policy dictates that only marijuana provided by the National Institute on Drug Abuse can be used for research — and it "is notorious for being low in THC and of poor quality", says Ilan.

    Lester Grinspoon, professor emeritus of psychiatry at Harvard Medical School in Boston, Massachussetts, who has studied the effects of marijuana on patients since 1967, says that Curran's study is important. "Cannabis with high cannabidiol levels will make a more appealing option for anti-pain, anti-anxiety and anti-spasm treatments, because they can be delivered without causing disconcerting euphoria," he says.


    Published online
    1 October 2010
    http://www.nature.com/news/2010/101001/full/news.2010.508.html
  11. skips
    This isn't the first time swim has heard of this, and he suspects it may be to convince those that previously used to smoke/saw no harm in smoking that todays cannabis is actually evil and dangerous and must be stopped.

    If weed being low in cannabidiol is responsible or used as justification for it still being classed as dangerous and thus illegal, then why not legalise cannabidiol and sell it, or legalise and standardise weed so it has a certain concentration of cannabidiol?
  12. Terrapinzflyer
    ^^ High CBD / low THC cannabis doesn't particularly get one "high" - and will never catch on for recreational use. It is however extremely promising in the field of medical marijuana, where it can provide many of the therapeutic effects without the often undesirable side effect of intoxication.

    It, along with more traditional medical preparations (ie, standardized and not requiring smoking) such as Sativex are seen by many as a key to federal approval as well as both doctor and patient acceptance of marijuana as medicine.
  13. echoes
    this is kinda funny lol like no shit sherlock. if you smoke more potent bud the effects and side effects will be stronger. and yea bud higher in CBD (indicas) are less psychedelic compared to sativa (higher in THC) dominant. swims preference is for indica's, when swim smokes 100% incia like dutch nebula, it's like taking opiates. VERY sedative. And he loves it HAHHA
  14. reformer
    That is physically impossible. No way that poor plant is 40% by weight cannabidiol. Where do they come up with these numbers?
  15. Terrapinzflyer
    The 40% number is unusually high- but the % are based on the overall cannabinoid content- not weight of the plant material.

    Normally high grade buds test out at ~10-15% THC and often only 1-2% CBD. When high CBD strains first really hit the market a year or two ago they were ~10% CBD and 3-4% THC. I don't have more recent numbers (nor time to research) but would assume the CBD to THC ratio has widened slightly more since then.
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