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Study links brain inflammation triggered by chronic pain to anxiety and depression

By RoboCodeine7610, Jun 11, 2015 | Updated: Jun 11, 2015 | | |
  1. RoboCodeine7610
    Brain inflammation caused by chronic nerve pain alters activity in regions that regulate mood and motivation, suggesting for the first time that a direct biophysical link exists between long-term pain and the depression, anxiety and substance abuse seen in more than half of these patients, UC Irvine and UCLA researchers report.

    This breakthrough finding also points to new approaches for treating chronic pain, which is second only to bipolar disorder among illness-related causes of suicide. About a quarter of Americans suffer from chronic pain, making it the most common form of enduring illness for those under the age of 60. The Institute of Medicine estimates that this costs our society more than $635 billion per year.

    In work with rodents, Catherine Cahill, associate professor of anesthesiology & perioperative care at UCI, Christopher Evans of UCLA's Brain Research Institute, and colleagues discovered that pain-derived brain inflammation causes the accelerated growth and activation of immune cells called microglia. These cells trigger chemical signals within neurons that restrict the release of dopamine, a neurotransmitter that helps control the brain's reward and pleasure centers.

    The study also reveals why opioid drugs such as morphine can be ineffective against chronic pain. Morphine and its derivatives normally stimulate the release of dopamine. But in research on mice and rats in chronic pain, Cahill and her colleagues learned that these drugs failed to stimulate a dopamine response, resulting in impaired reward-motivated behavior.

    Treating these animals in chronic pain with a drug that inhibits microglial activation restored dopamine release and reward-motivated behavior, Cahill said.

    'For over 20 years, scientists have been trying to unlock the mechanisms at work that connect opioid use, pain relief, depression and addiction,' she added. 'Our findings represent a paradigm shift which has broad implications that are not restricted to the problem of pain and may translate to other disorders.'

    The results of the five-year study appear online in the Journal of Neuroscience.

    Next, Cahill and her team aim to establish that pain-derived changes in human brain circuitry can account for mood disorders. 'We have a drug compound that has the potential to normalize reward-like behavior,' she said, 'and subsequent clinical research could then employ imaging studies to identify how the same disruption in reward circuitry found in rodents occurs in chronic pain patients.'

    University of California - Irvine.
    ScienceDaily, 9 June 2015.


  1. 5-HT2A
    Re: Study links brain inflammation triggered by chronic pain to anxiety and depressio

    Perhaps the overwhelming pain and trauma from forced neonatal circumcision could result in mood disorders as well through this same mechanism. Comments?
  2. noddygirl
    Re: Study links brain inflammation triggered by chronic pain to anxiety and depressio

    This is an interesting article, but I dont understand how "morphine and it's derivatives normally stimulate the release of dopamine?" What??? I thought it was endorphins.
  3. best
    Re: Study links brain inflammation triggered by chronic pain to anxiety and depressio

    @ noddygirl :

    Morphine is known to bind to the Mu Opioid Receptor, this also is where Beta Endorphin is known to bind to, when a typical Mu Opioid Agonist binds to the receptor it has shown to cause a decrease of GABA release, and this causes Dopamine to release at a higher rate, because GABA acts to Inhibit the release of Neurotransmitters.

    I havent ever read about Mu Opioid Agonists releasing Beta Endorphin, but Endorphins themselves are known agonists at the receptor.
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