Testosterone kills brain cells

By snapper · Sep 27, 2006 · ·
  1. snapper
    Too much testosterone kills brain cells
    POSTED: 3:23 p.m. EDT, September 27, 2006

    WASHINGTON (Reuters) -- Too much testosterone can kill brain cells, researchers say, in a finding that may help explain why steroid abuse can cause behavior changes such as aggressiveness and suicidal tendencies.

    Tests on brain cells in lab dishes showed that while a little of the male hormone is good, too much of it causes cells to self-destruct in a process similar to that seen in brain illnesses such as Alzheimer's.

    "Too little testosterone is bad, too much is bad but the right amount is perfect," said Barbara Ehrlich of Yale University in Connecticut, who led the study.

    Testosterone is key to the development, differentiation and growth of cells and is produced by both men and women, although men produce about 20 times more of the hormone.

    It can also be abused, and recent scandals have involved athletes who use the hormone, or steroids that turn into testosterone in the body, for an unfair advantage.

    "Other people have shown that high levels of steroid can cause behavioral changes," Ehrlich said in a telephone interview.

    "We can show that when you have high levels of steroids, you have high testosterone and that can destroy the nerve cells. We know that when you lose brain cells you lose function."

    Ehrlich's team tried the same thing with the "female" hormone estrogen, just to be fair.

    "We were surprised, but it actually looks like estrogen is neuroprotective. If anything, there is less cell death in the presence of estrogen," she said.

    Writing in the Journal of Biological Chemistry, Ehrlich and colleagues said their findings meant people should think twice about supplementing with testosterone, even if it does build muscle mass and aid recovery after exercise.

    "These effects of testosterone on neurons will have long-term effects on brain function," they wrote.

    "Next time a muscle-bound guy in a sports car cuts you off on the highway, don't get mad -- just take a deep breath and realize that it might not be his fault," Ehrlich said in a statement.

    The cells die via a process called apoptosis, also known as cell suicide or programmed cell death.

    "Apoptosis is an important thing for the brain -- the brain needs to weed out some of the cells. But when it happens too frequently, you lose too many cells and causes problems."

    A similar process is seen in Alzheimer's disease, the most common cause of dementia in the United States, affecting an estimated 4.5 million Americans, and Huntington's disease, another fatal brain illness.

    "Our results suggest that the responses to elevated testosterone can be compared with these pathophysiological conditions," the researchers wrote.


    Thought all you 'roid heads out there might want to know..

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  1. stoneinfocus
    so what´s a high level? is ther eevidence in vitro, and what about the elevated estrogen in testosterone-use, via aromatase?

    How I love half-assing the truth.

    Swim has nothing but more concentration, a more stable circadian rhythm, no more depression and a lot more mpathy, with slightly supra-physiological levels of testosterone.

    He recovered with testo and hgh et al. rom a really bad accident, so quickly, that it wasn´t even funny to some, like it seemed.
  2. London_Bloke
    Unfortunately, the cellular damage is more often directly observed as black eyes on the women who fall for men such as these....

    Not speaking of present company, of course.
  3. El Calico Loco
    Steroids are good for men in small amounts - that being, amounts that would bring the level of the older man's testosterone back up to what it was when he was a younger man. They can help men retain youth and vigor as they age.

    Much more than that, and you get a diseased brain and missing testicles. Some bodybuilding meatheads regularly inject something like 20 times more testosterone than they really need; it's no wonder they have mental problems.

    (And no balls. :D )
  4. Praxis
    Holy shit guys! Did you here that shallowing small amounts of saliva ever day over a long period of time will kill you!? HOLY SHEITE!
  5. AntiAimer
    O no....that there going to make it illegal to be manly.
  6. Praxis
    negative credit for my comments above? Its amazing how some people are so anal and completely void of a sense of humor. I was merely making a comment symbolizing how our society seems to be condemning everything. Even our own sun is a health hazard. Sheesh. Take the forrest out of ye ass.
  7. AntiAimer
    Wtf, are you talking about man?:smoker:
  8. Donmeka
    he doesnt know
  9. godismdma
    So based on this study men and woman who smoke regularly should be using testosterone. Considering I dont remember if it was nicotine or something else but ciggarets lower your testosterone levels. There is so much science does not know about the body especially when it comes to harmones!
  10. Riconoen {UGC}
    Oh shit, now castration is going to be mandatory.
  11. El Calico Loco
    Funny...men and women have the same average IQ score, but the bell curve for men is wider - meaning that the male half of the species has more geniuses and more idiots, on average.

    I wonder where testosterone comes into play. It would be sad if the strongest, healthiest, and most handsome men also turned out to be the dumbest.

    (Sad, but not shocking...least, not to those of us who are diminutive, brainy, and cranky. :D)
  12. stoneinfocus
    We´d be rather not talking about omnipresent stupidity in mankind, myself being no exclusion from this one and, maybe `occasional´, comorbidity in some steroid users. -beside this fact, as mentioned above, testosterone undergoes
    a tantan conversion to estrol by the aromatase enzyme, which is concluded to protecting braincells here, and after spending hours of hours, in years over years, I ´ve never come across a proven study, that was mentioning IQ issues or braindamage problems, or probs with certain tasks in heavy or light steroid-users, the only one I´ve found was, that a large dose of a very androgenic steroid, which testosterone or a huge dose of it is, might slow down speech and building words, but then again, testosterone enhances logical thinking as in mathematical task, etc. ...,which might explain the lingual talent of women opposed to men... why it´s said to be happenign in gays, too, I don´t know, I know, I´m not lacking testosterone for sure:D and think having a talent, as most gays, maybe a hybird? ...probably logic might be used to learn languages, if applied to one?:D I don´t know ??

    And, oh -if testosterone would make you stupid, castrationa and testosterone replacement or at least the latter, were adverstised and maybe sometimes a forced treatment to take care of the health of every individual and the welath of society!
  13. Riconoen {UGC}
    no offense coincidence but I cannot make heads or tails of your post, please clarify it so I can properly respond to it.
  14. London_Bloke
    Agreed - The words are English, but any similarity seems to end there.

    **whew** I thought it was just me.
  15. OccularFantasm
    That is quite interesting but not surprising. Swim beleives this is actually the reaon people consider marijuana to be addictive. Marijuana eliminates excess testosterone (way more effectively than cigarettes swim would imagine). Excess testosterone causes bad descion making. For example you just smoke a whole blunt and this kid starts talkin shit to you. You just say hey man get outta here man i dont feel like fighting. Ok now, same situatoin, take out the blunt. Kid comes up bothering you, and then bam all of a sudden he has to goto the hospital. Easily one could alter the person who didnt smoke weed to a persont aking excess testosterone and the person who did smoke to the person not taking excess testosterone, if it helps for any of swiy to relate, as results owuld be the same. Swim beleives this is what many people consider marijuana withdrawl. Swim also find it ironic, that with this evidence, the anti-pot commerical, is not telling kids to kill their brain cells. You know the commercial. There are kids on a couch smoking weed not in any trouble, and then there are kids without weed going around almost hurting themselves at every turn making bad descions. The point is supposed to be dont be boring dont smoke weed, although swim would have preferred the couch himself. Its just funny that what it is really saying, is kill your brain cells, make bad descions, and endanger your own health, because you don't want weed to make you smarter.
  16. stoneinfocus
    it makes all sense if you think "german" and see the irony and cynics, that are laced into it. *lol*

    The last sentence, iwas meant like, "we ought to be stupid, so if testosterone would make us stupid, it would be mandatory to take it."

    But as I see it, the lack of testosterone makes us stupid and lethargic and makes us lack of logical thinking and taking action to this thinking.

    FYI, obesity is _the_ testosterone killer non plus.... and beer/alcohol.
    That´s why you´re gettign fat and grow titties along getting fat/drinking alcohol.
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