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  1. source
    DOCTORS like to project an air of authority when making their clinical decisions. Patients like it too, for it is reassuring to think that one’s health is in the hands of an expert.

    It would be unsettling if, upon prescribing you a drug, your doctor admitted that the scientific research about what exactly the drug did, and how effective it was at doing it, was patchy and distorted, sometimes to the point where nobody has any real idea of what effects the drugs they are prescribing are likely to have on their patients.

    But that is the reality described in “Bad Pharma”, Ben Goldacre’s new book. A British doctor and science writer, he made his name in 2008 with “Bad Science”, in which he filleted the credulous coverage given in the popular press to the claims of homeopaths, reiki therapists, Hopi ear-candlers and other purveyors of ceremonious placebos.

    Now he has taken aim at a much bigger and more important target: the $600-billion pharmaceutical industry that develops and produces the drugs prescribed by real doctors the world over.

    The book is slightly technical, eminently readable, consistently shocking, occasionally hectoring and unapologetically polemical. “Medicine is broken,” it declares on its first page, and “the people you should have been able to trust to fix [its] problems have failed you.” Dr Goldacre describes the routine corruption of what is supposed to be an objective scientific process designed to assess whether new drugs work, whether they are better than drugs already on the market and whether their side effects are a price worth paying for any benefits they might convey. The result is that doctors, and the patients they treat, are hobbled by needless ignorance.

    So, for instance, pharmaceutical companies bury clinical trials which show bad results for a drug and publish only those that show a benefit. The trials are often run on small numbers of unrepresentative patients, and the statistical analyses are massaged to give as rosy a picture as possible. Entire clinical trials are run not as trials at all, but as under-the-counter advertising campaigns designed to persuade doctors to prescribe a company’s drug.

    The bad behaviour extends far beyond the industry itself. Drug regulators, who do get access to some of the hidden results, often guard them jealously, even from academic researchers, seeming to serve the interests of the firms whose products they are supposed to police.

    Medical journals frequently fail to perform basic checks on the papers they print, so all sorts of sharp practice goes uncorrected. Many published studies are not written by the academics whose names they bear, but by commercial ghostwriters paid by drug firms. Doctors are bombarded with advertising encouraging them to prescribe certain drugs.

    The danger with a book like this is that it ends up lost in abstract discussion of difficult subjects. But Dr Goldacre illustrates his points with a plethora of real-world stories and examples. Some seem almost too breathtaking to be true—but every claim is referenced and backed up by links to research and primary documents.

    In scenes that could have come straight from a spy farce, the French journal Prescrire applied to Europe’s drug regulator for information on the diet drug rimonabant. The regulator sent back 68 pages in which virtually every sentence was blacked out.

    And of course, the upshot of all this is anything but abstract: doctors are left ignorant about the drugs they are prescribing, and which will make their patients sick or get well, or even live or die. Statins, for instance, lower the risk of heart attacks, and are prescribed to millions of adults all over the world. But there are several different sorts of statin. Because there is little commercial advantage to be gained by comparing the efficacy of the different varieties, no studies have done so in a useful way.

    Bereft of guidance, doctors must therefore prescribe specific statins on the basis of little more than hunches or personal prejudice. As Dr Goldacre points out, if one drug is even a shade more effective than its competitors, then thousands of people prescribed the inferior ones are dying needlessly every year for want of a bit of simple research.

    That is a scandal. Worse, the bias and distortions that brought it about are repeated across the entire medical industry. This is a book that deserves to be widely read, because anyone who does read it cannot help feeling both uncomfortable and angry.

    The Economist, 28th September 2012
    http://www.economist.com/node/21563689

Comments

  1. Dr.Evil
    Good find, but overall this book is a stupid thing to release in my honest opinion. I am in the medical field and can say that most everything stated above is true, but this guy seems to be implying that this is very common and the medical system is broken because of it. Not true. This stuff is happening and it is a problem, but only in very specific instances like the very new statins ( only bad doctors prescribe the newer ones anyways, because there isn't enough research to support their use over the older and better tested drugs).

    That all being said, this doctor is just trying to make some cash. The way to change the system isn't by making the public trust their doctors less. It's by educating said doctors to make better decisions when prescribing medications.

    Sorry for the mini- rant but I run into bad doctors prescribing medications that aren't indicated every once in a while and it pisses me off.
  2. constant limbo
    i'm not being cheeky mate.....

    by your own admission the contents of the book are mostly true,yet you say it's a stupid thing to release,as it will cause people to miss trust their doctors

    surely if doctors are prescribing on a hunch or personal predjudice,also that medical journals frequently fail to perform basic checks on papers they print,and that many of the published studies are being written by commercial ghostwriters paid by the drug companys

    then imo people would be correct in showing concern even mistrust in doctors,it is after all the people who will suffer if mistakes are made

    surely it's better to get this out there,so folk can voice concern at these practices and hopfully get the system changed

    you say the way to change the system isn't by making the public trust doctors less,but surely attempts at hiding these facts,would cause more mistrust than being open and making people aware that something is wrong

    i agree educating doctors to make better decisions when prescribing medications would be a good starting point,the problem i forsee with this is,all the skull duggery being done by large pharmaceutical companys,trying to safeguard the billions they make each year

    cheers,constant limbo
  3. BitterSweet
    I have long been cautious with doctors based on some of the issues apparently addressed in this book. The author does sound like he is creating a sense of fear without including positive things we can bank on. Basically the book sounds like it is saying the medical industry is bad and this is why; but people do need to be more aware of this issue to address it and protect themselves.
  4. Sleuthmaster
    My husband and I were both prescribed statins. Mine nearly destroyed my liver. My husbands made him impotent. We have both stopped taking them and VOILA! back to normal. ;)
    The diet and exercise path is always a better way to go.
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