1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.

US invents new anti-suicide drug for soliders

By AnrBjotk, Aug 19, 2012 | Updated: Aug 19, 2012 | | |
  1. AnrBjotk
    Latest news: "For those feeling down in the dumps, the US military now has a solution: an anti-suicidal nasal spray that delivers antidepressant chemicals to the brain."

    WHY arent they just given morphine or subutex? Why waste money inventing some new drug that is just gonna hit the streets anyway? If a person is suicidal why not just give them some opiates?


  1. runnerupbeautyqueen
    Here's the actual article

    For those feeling down in the dumps, the US military now has a solution: an anti-suicidal nasal spray that delivers antidepressant chemicals to the brain.

    The US Army has awarded a scientist at the Indiana University School of Medicine $3 million to develop a nasal spray that eclipses suicidal thoughts. Dr. Michael Kubek and his research team will have three years to ascertain whether the nasal spray is a safe and effective method of preventing suicides.

    The research grant comes after the Army lost 38 of its soldiers to suspected suicide in July, setting a record high. So far in 2012, the Army has confirmed 66 active duty suicides and is investigating 50 more, making a total of 116 cases.

    The Army’s suicide rate is at the highest level in history, with more American soldiers taking their own lives than being killed by the Taliban. The Pentagon reported in June that suicides among soldiers averaged one per day this year, surpassing the rate of combat fatalities.

    But the naturally occurring neurochemical thyrotropin-releasing hormone (TRH) could slow the rising suicide rate. The chemical has a euphoric, calming, antidepressant effect. TRH has been shown to decrease suicidal ideas, depression and bipolar disorders.

    “We’ve known since the 1970s that TRH has antidepressant effects, and it works quite rapidly,” Kubek told The Daily. “The bottom-line problem has been figuring out how to get it into the brain.”

    Until now, doctors have only been able to transmit TRH through injections into the spinal cord. Pills and blood injections do not allow TRH to enter the brain. But with new technology, Kubek’s team of research scientists has found the nasal cavity can safely carry TRH across the blood-brain barrier. “This is far from a soldiers-only solution,” Kubek said. “Potentially, if this works, we have an entirely new type of pharmacology.”

    If the nasal spray is proven effective, soldiers in crisis or those taking other antidepressants would also be given TRH.

    “The phase directly after starting an antidepressant is a very vulnerable time frame in a patient’s life,” Dr. Ken Duckworth, medical director for the National Alliance on Mental Illness, told The Daily. “The nasal spray would stabilize them right away, while they wait for the [antidepressants] to do their job.”
    While the suicide rate is increasing in the military, it is also an increasing concern in the US civilian population.

    Suicide is the fourth leading cause of death for adults between the ages of 18 and 65 years. Every day, more than 100 Americans take their own life.
  2. AnrBjotk
    Uhu... Any views on that Runner?
  3. Exitlude
    These are soldiers who have been in a warzone. Men who are paid to fight and kill other men and watch their brothers in arms die. Morphine dulls the pain. Anti-depressants allow one to live with the pain. Treatment for something as serious as shell shock/PTSD/whatever you call fighting a bloody war can only be effective if the pain is actually present and the contributing factors can be addressed. This anti-suicide nasal spray would probably be the first medication administered when a crisis is identified (even that is questionable, how many imminently suicidal individuals will the presence of mind to seek out and administer this spray), which is intended to be followed up with psychotherapy and long-term medications if required.

    Introducing people with serious mental health problems to drugs of addiction is wrong, anyway. Thanks for linking to the article though, it offered some valuable insight.
  4. AnrBjotk
    Mhm. Yes and no.
    Though drug addiction is bad, how many people are not addicted to SSRI's? How many do not choose to stay on SSRI's that don't work rather then suffer the WDs?

    My point is, and as I have purported in other threads, either this Nasal drug works and therefore makes you happy and ipso facto is addictive in some sense, Or it does not work, does not increase mood and therefore is not addictive.
    If it actually works, if it actually increases your mood, unlike SSRI's who might work but not instantly like this claims to, it could be considered a recreational drug.
    Then why not just use opiates, which you Know will increase mood and let the army deal with any addiction that might occur?
    Like my previous posts about using opiates as antidepressants, like it has with subutex, why is it out of the question? Surely a suicidal person should be given something guaranteed to increase their mood right away.
    Better addicted than dead, no?
  5. Exitlude
    No. It's a natural reaction for a human to kill themselves when pain exceeds coping resources.

    I'm assuming you are a fellow user like myself and know where opioid addiction can take you. Why would you wish that hell upon someone who is already suffering through the loss of their entire former selves, their identity, their sanity? Sure, if there's a never ending supply then you retire into eternal bliss. But the essence of the problem is that you never have enough. Also, who pays for these millions of opiate addicts in a state of suspended suicidal intent as long as they're high?
  6. SpatialReason
    Oh god, I hope a moderator steps in here soon and fixes this...

    Better addicted than dead...

    AnrBjotk, by saying that, you just stepped on the worst landmine of them all. That is unforgivable here. Not to mention, your original thread post is absolute rubbish without the need for explaining. I think everyone here, even the most unfamiliar, knows the difference between painkillers and mood stabilizers...

    Opiates can help, yes, but implying addictive drugs as a solution and welcoming addiction as an okay solution openly is wrong. Opiates can create warmth like no other that helps, but it most certainly will not save a damaged soul from chemically driven depression.
  7. source
    Hmm wouldn't like to live in a country that is defended by soldiers on opiates. What a ridiculous suggestion.

    Your last comment is also an odd thing to say, I really have no reply to that other than WTF =/
  8. AnrBjotk
    I do have experience with addiction. And though I have never experienced much pain with addiction, none really, after being on subutex program, I guess, with some stretch of the imagination, I can understand.
    What I can say is that suicidal depression, clinical depression and severe despair is worse than any addiction I can imagine.
    Of course, being a junkie on the streets is one of the worst ways to live, what i suggested was that the army would supply methadone and any therapy should addiction take over.
    Opiates increases mood, that's a fact, and the addiction is a problem when forced to buy dangerous drugs on the streets and steal in order to get money, plus diseases and infections.
    But, if we imagine a traumatized soldier gets a shot of morphine to remove despair, and stop the trend of suicide, is that not better? Then the addiction can be managed by doctors.

    Does anyone know what this nasal drug does? Because having experience with antidepressants, I know they do not make you feel "good" right away, and rarely ever.
    Is not the key to have a chemical that elevates mood rapidly and masks trauma, since trauma cannot be removed except with therapy.
    Just like subutex is being used more and more in treating severe depression.

    Why is that such a wasps nest to claim?
  9. SpatialReason
    It'd behoove you to say all of that from the start with your claims, opinions, and statements.

    I respectfully agree and disagree. The issue is that you can't hand something to someone with the risk of creating a bigger problem. If they just finished fighting one battle in a war, why send them to fight another front: addiction.

    You'd get a lot more addicts with no working value than happy and produtive veterans. More are likely to kill themselves due to having trauma AND addiction. Man, that would be hell on earth...

    In my opinion, Ketamine is a better instant-fix substance for onslaughts of suicidal depression. It has the right sort of brain interacting properties and calming effects, with many medical journals backing the NMDA receptor interaction claim, to be effective in helping what your original thread addresses.
  10. Docta
    It's easy to forget that opiates have been used, abused and prescribed as a remedy come therapy for war related PTSD from time immemorial and well documented by the USVA, from the US civil war on.

    There is not much in this thread that we haven't discussed here before with gulf war vets and so on, so no harm no foul.
  11. SpatialReason
  12. kumar420
    so now they have rapid-action antidepressants to try and cope with PTSD? stupid, in my opinion. antidepressants mask symptoms as much as any other drug, and its not the way to go about treating traumatised soldiers. they should be receiving therapy, not intra-nasal SSRI's and shit... big pharma strikes again?
    EDIT: reread the article and its not an SSRI or any other type of traditional medication, since its a natural occurring hormone its not quite so bad... however i still don't like the predecent.
  13. Alien Sex Fiend
    Swim didn't know soldiers were that suicidal. Don't they get paid 100$ an hour?
    I still doubt this: nasal spray so soldiers don't commit a suicide? come on, this sounds bunk
  14. profesor
    BUNK! Most antidepressants take weeks to be effective. The SSRIs and SNRIs, and even other antidepressants have short-term increase in suicidality. The main problem is, there may be many periods of suicidal ideation before other symptoms of depression occur. Once a person is deeply depressed they may no longer have the will, energy or even confidence to act on those thoughts and feelings. Ironically, sufferers can be too depressed to attempt suicide (thinking one will not succeed at suicide as they feel about other goal-driven activities!)
    Okay, now introduce a medication or chemical which will energize the body and increase confidence-- the sufferer has the same suicidal ideation- but is now physically and emotionally able to carry out an attempt! This phenomenon is also observed in depressed patients who aren't taking any medication- they cheer up, feel better and see a (short) future for themselves, all because of the decision to finally go through with it!
    So a short acting chemical (I won't dignify the mythical substance as a medication) is highly likely to increase suicide rates, and any decent clinician would recognize this.
    The whole concept is actually very insulting to depression sufferers, because it implies suicidal thoughts and feelings can be cured with a magic nasal spray. It trivializes suicide.
  15. profesor
    On a lighter note, haven't any of you seen "Apocalypse Now"? The Vietnam War did have high rates of drug use, and in particular opiate use, and that didn't turn out very well.
    On the other hand, I wonder if methoxetamine has similar antidepressant properties as ketamine. It might possibly be helpful to relieve some of the symptoms of depression quickly.
  16. SpatialReason
    This is where I think they need to experiment with the Ketamine anti-depressant theoretical property. In fact, the "theoretical" word should be "realistic" as it is proven but without much in terms of widespread clinical tests. I think the soldier aspect is perfect since the results would be immediate, and it would also give promise to eliminate some of the physical pain for a bit. It is a win-win for everyone. Physical and emotional pain can be dealt with, a soldier gets money for tests, medical advancements in the field of psychoactive drugs go further, and everyone leaves happy.
To make a comment simply sign up and become a member!