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Opium, Opiate & Opioids Documents
Documents about Morphine, Codeine, Buprenorphine, Fentanyl, Heroin, Hydrocodone, Methadone, Oxycodone, Tramadol and other opiates and opioids.
New entries announced in forum Opiates & Opioids
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Codeine Documents [19 entries]
Fentanyl Documents [23 entries]
Heroin Documents [85 entries]
Hydrocodone Documents [14 entries]
Methadone Documents [44 entries]
Morphine Documents [35 entries]
Oxycodone Documents [27 entries]
Tramadol Documents [53 entries]

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Access denied (2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics
J Med Chem. 1991 Jan;34(1):397-403.
Vecchietti V, Giordani A, Giardina G, Colle R, Clarke GD.

Abstract

This paper describes the synthesis and structure-activity relationships as kappa opioid analgesics of a novel class of 1-(arylacetyl)-2-(aminomethyl)piperidine derivatives. The active...
 
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Submitted by Anonymous Find all entries from this user
11-11-2010
912.74 Kbytes Hits 20
Keywords: opioid kappa analgesics
Access denied 75 years of opioid research: the exciting but vain quest for the Holy Grail 5 *
British Journal of Pharmacology 2006 Jan;147 Suppl 1:S153-62

Corbett AD, Henderson G, McKnight AT, Paterson SJ.

Over the 75-year lifetime of the British Pharmacological Society there has been an enormous expansion in our understanding of how opioid drugs act on the nervous system, with much...

See also Drug History Documents 
 
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Submitted by Jatelka Find all entries from this user
05-05-2009
256.46 Kbytes Hits 145
Access denied :THE HISTORICAL SHIFT IN THE PERCEPTION OF OPIATES: FROM MEDICINE TO SOCIAL MENACE
(I used file archive search and this did not give a hit, Delete if its there)

THE HISTORICAL SHIFT IN THE
PERCEPTION OF OPIATES: FROM MEDICINE
TO SOCIAL MENACE

John P. Hoffmann

Abstract -- An examination of the origins of the laws prohibiting the use of opiates in the United States is...
 
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Submitted by Basoodler Find all entries from this user
29-10-2012
56.77 Kbytes Hits 12
Access denied A case of acute intoxication due to combined use of fentanyl and 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700) (2016)
Forensic Science International, September 2016, Vol.266, pp.68-72

Coopman, Vera ; Blanckaert, Peter ; Van Parys, Geert ; Van Calenbergh, Serge ; Cordonnier, Jan

•Fatality involving fentanyl and U-47700: case histories and analytical findings.•Determination of U-47700 in blood and urine by...
 
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Submitted by Calliope Find all entries from this user
14-10-2016
606.74 Kbytes Hits 3
Access denied A case of U-47700 overdose with laboratory confirmation and metabolite identification (2016)
Clinical Toxicology, 08/23/2016, pp.1-5

Jones, Matthew J. ; Hernandez, Bradley S. ; Janis, Gregory C. ; Stellpflug, Samuel J.

ABSTRACT
Context: The opioid epidemic has included use of traditional drugs and recently newer synthetics. It ismcritically important to recognize and identify these...
 
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Submitted by Calliope Find all entries from this user
14-10-2016
671.99 Kbytes Hits 3
Access denied A comparison of the analgesic effect of oxymorphone by rectal suppository and intramuscular injection in patients with postoperative pain. (1977)
Journal of Clinical Pharmacology. 1977 May-Jun; 17 (5-6): 276-91.

Beaver WT, Feise GA.

Abstract:

The relative analgesic potency of oxymorphone by rectal suppository and intramuscular injection was evaluated in a double-blind, twin-crossover comparison of graded single doses in 136 patients...
 
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Submitted by Calliope Find all entries from this user
20-08-2012
873.39 Kbytes Hits 8
Keywords: pain-treatment oxymorphone intramuscular dosage analgesia
Access denied A comparison on the abuse liability of tramadol, NSAIDs and hydrocodone in patients with chronic pain
Adams EH, Breiner S, Cicero TJ, Geller A, Inciardi JA, Schnoll SH, et al. Journal of Pain & Symptom Management 2006 May;31(5):465-76.

Concern about abuse/dependence in chronic pain patients taking opioid analgesics may lead to undertreatment of pain, yet little is known about the prevalence of...
 
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Submitted by Paracelsus Find all entries from this user
22-03-2007
104.50 Kbytes Hits 109
Access denied A Fatality Related to the Synthetic Opioid U-47700: Postmortem Concentration Distribution (2016)
J Anal Toxicol. 2016 Oct 26. [Epub ahead of print]

Iain M. McIntyre*, Ray D. Gary, Sandra Joseph, and Robert Stabley

Abstract
In this case report, we present an evaluation of the distribution of postmortem concentrations of 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide...
 
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Submitted by Calliope Find all entries from this user
18-12-2016
95.18 Kbytes Hits 1
Access denied A review of the clinical pharmacokinetics of opioids, benzodiazepines, and antimigraine drugs delivered intranasally (2009)
Clinical Therapeutics, Vol. 31, Issue 12, Dec.2009, Pages 2954–2987

Nicole M.L. Veldhorst-Janssen, Audrey A.A. Fiddelers, Paul-Hugo M. van der Kuy, Cees Neef, Marco A.E. Marcus

Abstract:
- BACKGROUND: Interest in the development of drug-delivery devices that might improve treatment...

See also Benzodiazepines Documents  Pharmacology Documents 
 
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Submitted by Behrang Find all entries from this user
06-08-2014
317.03 Kbytes Hits 14
Access denied A Web-Based Study of Self-Treatment of Opioid Withdrawal Symptoms with Loperamide. 5 *
An interesting web-based study on loperamide discussions.  
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Submitted by Mindless Find all entries from this user
15-06-2014
366.95 Kbytes Hits 61
Keywords: cns effects opioid pharmacokinetics withdrawal loperamide
Access denied Abuse Liability of Prescription Opioids Compared to Heroin in Morphine-Maintained Heroin Abusers (2007)
Neuropsychopharmacology (2007), 1–13

Sandra D Comer, Maria A Sullivan, Robert A Whittington, Suzanne K Vosburg and
William J Kowalczyk

Abuse of prescription opioid medications has increased dramatically in the United States during the past decade, as indicated by a variety of...
 
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Submitted by Jatelka Find all entries from this user
23-02-2008
167.63 Kbytes Hits 95
Keywords: buprenorphine fentanyl heroin morphine opioids oxycodone
Access denied ACMD advice on O-desmethyltramadol
ACMD letter to home secretary recommending the scheduling of o-desmethyltramadol to class B, along with notification that ACMD will review tramadol itself in Dec 2012

See also Law Documents  Research Chemicals Documents 
 
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Submitted by davestate Find all entries from this user
01-11-2012
77.64 Kbytes Hits 29
Access denied An Opioid Agonist that Does Not Induce Opioid Receptor-Arrestin Interactions or Receptor Internalization
C. E. Groer, K. Tidgewell, R. A. Moyer, W. W. Harding, R. B. Rothman, T. E. Prisinzano, and L. M. Bohn

G protein-coupled receptor desensitization and trafficking are important regulators of opioid receptor signaling that can dictate overall drug responsiveness in vivo. Furthermore, different...

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Submitted by Gradient Find all entries from this user
27-09-2009
487.84 Kbytes Hits 39
Access denied Analgesics in Patients with Hepatic Impairment: Pharmacology and Clinical Implications (2012)
Drugs, 72, 12, 1645-1669(25)

Bosilkovska, Marija; Walder, Bernhard; Besson, Marie; Daali, Youssef; Desmeules, Jules

Abstract
The physiological changes that accompany hepatic impairment alter drug disposition. Porto-systemic shunting might decrease the first-pass metabolism of a drug and...
 
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Access denied Analysis of Novel Synthetic Opioids U-47700, U-50488 and Furanyl Fentanyl by LC–MS/MS in Postmortem Casework (2016)
Journal of Analytical Toxicology, 09/01/2016

Mohr, Amanda L. A. ; Friscia, Melissa ; Papsun, Donna ; Kacinko, Sherri L. ; Buzby, David ; Logan, Barry K.

Abstract
Following series of synthetic cannabinoid and synthetic cathinone derivatives, the illicit drug market has begun to see increased...
 
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Submitted by Calliope Find all entries from this user
13-10-2016
252.04 Kbytes Hits 3
Access denied Analytical characterization and comparison of the blood–brain barrier permeability of eight opioid peptides
Peptides. 2010 Jul;31(7):1390-9. Epub 2010 Mar 27.
Van Dorpe S, Adriaens A, Polis I, Peremans K, Van Bocxlaer J, De Spiegeleer B.

Abstract

Opioid drugs, including the newly developed peptides, should penetrate the blood-brain barrier (BBB) for pain management activity. Although BBB transport...
 
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Submitted by Anonymous Find all entries from this user
05-11-2010
762.96 Kbytes Hits 12
Keywords: peptides opioid dermorphin
Access denied Antagonism of the discriminative stimulus effects of the kappa-opioid agonist spiradoline
Psychopharmacology (Berl). 1994 Nov;116(3):243-8.
Holtzman SG, Steinfels GF.

Abstract

This study compared the potency of mixed-action opioids (i.e., agonist-antagonists) and pure antagonists to block the discriminative stimulus effects of spiradoline, a kappa-opioid agonist. Rats were...
 
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11-11-2010
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Keywords: spiradoline opioid kappa analgesics
Access denied Anti-nociceptive effects in N-substituted cyclohexylmethylbenzamides.
Br J Pharmacol. 1973 September; 49(1): 158P–159P.
R. T. BRITRAIN*, D. N. KELLETT, M. L. NEAT and R. STABLES

In the mouse, certain N-substituted cyclohexylmethylbenzamides markedly inhibited
writhing induced by phenylquinone and the nociceptive responses to being placed on
a hot plate (550 C)...

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Submitted by davestate Find all entries from this user
26-09-2012
200.66 Kbytes Hits 17
Keywords: ah7921 ah-7921
Access denied Availability of Opiates for Medical Needs
INCB report of 1996 first highlighted by stoneinfocus, but not uploaded.

Report in cooperation with WHO, to
ascertain whether Governments have fully implemented the recommendations contained in its special
report of 1989, to identify Governments that have not yet fully implemented the...
 
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Submitted by Lunar Loops Find all entries from this user
19-06-2008
112.76 Kbytes Hits 85
Access denied Basal signaling activity of µ opioid receptor in mouse brain: Role in narcotic dependence
Narcotic analgesics cause addiction by poorly understood mechanisms, involving µ opioid receptors (MOR). Previous cell culture studies have demonstrated significant basal, spontaneous MOR signaling activity, but its relevance to narcotic addiction remained unclear. In this study, we tested basal...

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Submitted by Gradient Find all entries from this user
17-04-2009
364.70 Kbytes Hits 56
Access denied Benzimidazol-Derivate und verwandte Heterocyclen III. Synthese von 1-Aminoalkyl-2-nenzyl-nitro-benzimidazolen
Benzimidazol-Derivate und verwandte Heterocyclen III. Synthese von 1-Aminoalkyl-2-nenzyl-nitro-benzimidazolen

A. von Hunger, J. Kebrle, A. Rossi, K. Hoffmann

Helvetica Chimica Acta (1960), Volume XLIII, No. 132

Abstract: The synthesis of a series of...

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Submitted by Phenoxide Find all entries from this user
30-04-2012
1.64 Mbytes Hits 39
Keywords: chemicals opioid metonitazene etonitazene nitazene clonitazene
Access denied Biogenic amines and active polypeptides of the amphibian skin
Annu Rev Pharmacol. 1971;11:327-50.
Erspamer V.
 
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Submitted by Anonymous Find all entries from this user
10-11-2010
2.92 Mbytes Hits 10
Keywords: peptides opioid dermorphin
Access denied Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs (2008)
Brain Research Reviews 2008 Jun;58(1):192-208

Cunha-Oliveira T, Rego AC, Oliveira CR

Abstract: Substance abuse and addiction are the most costly of all the neuropsychiatric disorders. In the last decades, much progress has been achieved in understanding the effects of the drugs of abuse in...

See also Cocaine & Crack Documents  Amphetamine Documents 
 
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Submitted by Gradient Find all entries from this user
19-07-2009
569.08 Kbytes Hits 85
Access denied Central serotonergic neurons are differentially required for opioid analgesia but not for morphine tolerance or morphine reward
Zhao ZQ, Gao YJ, Sun YG, Zhao CS, Gereau RW, Chen ZF. Proceedings of the National Academy of Sciences Aug 20 (early edition) 2007

Discussion Thread (https://drugs-forum.co.uk/forum/showthread.php?t=37738)
 
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Submitted by Heretic.Ape. Find all entries from this user
28-08-2007
420.14 Kbytes Hits 46
Keywords: opioid serotonin analgesic tolerance
Access denied Changes in Illicit Opioid Use in Canada (Fisher et al, 2006)
Originally published in The Canadian Medical Journal  
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Submitted by Jatelka Find all entries from this user
18-09-2007
485.80 Kbytes Hits 81
Keywords: opioids drug-use
Access denied Changes in resting EEG following methadone treatment in opiate addicts (2014)
Clinical Neurophysiology, Vol. 126, Issue 5, Pages 943-950, 2015.May

Grace Y Wang, Rob Kydd, Trecia A Wouldes, Maree Jensen, Bruce R Russell

Abstract:
-Objective: This study investigated the electrophysiological activity associated with methadone maintenance treatment (MMT).
-Methods: The...

See also Methadone Documents 
 
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Submitted by Behrang Find all entries from this user
11-05-2015
581.90 Kbytes Hits 5
Keywords: opiate methadone eeg dependence
Access denied Characterization of the receptor binding profile of (3H)-dermorphin in the rat brain
Int J Pept Protein Res. 1988 Dec;32(6):506-11.
Amiche M, Sagan S, Mor A, Delfour A, Nicolas P.

Abstract

Amphibian skin synthesizes a variety of biologically active peptides. Of these, dermorphin (Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2) is an extraordinarily potent opioid peptide up to 1000 times...
 
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06-12-2010
685.92 Kbytes Hits 12
Keywords: dermorphin
Access denied Chromatographic study of expert and biological samples containing desomorphine".
7. 9. Savchuk, S. A.; Barsegyan, S. S.; Barsegyan, I. B.; Kolesov, G. M. (2011). "Chromatographic study of expert and biological samples containing desomorphine".

Journal of Analytical Chemistry 63 (4): 361–70.

doi:10.1134/S1061934808040096 .
 
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27-09-2013
206.44 Kbytes Hits 11
Access denied Chronic pain and addiction: challenging co-occurring disorders (2012)
J Psychoactive Drugs.2012 Apr-Jun;44(2):119-24.

Pohl M, Smith L

Chronic pain is commonly treated by prescribing an opioid medication. For those suffering from both chronic pain and substance dependence, barriers to adequate pain management increase. This often causes both disorders to...

See also Opiate Addiction Documents 
 
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Submitted by Jatelka Find all entries from this user
29-06-2013
85.55 Kbytes Hits 15
Keywords: addiction opiates chronic-pain
Access denied Chronic Pain Management with Opioids in Patients with Past or Current Substance Misuse Problems (Fudin et al 2003)
Originally published in The Journal of Pharmacy Practice. A really interesting overview.  
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09-08-2006
151.01 Kbytes Hits 121
Keywords: opioids
Access denied Chronic use of opioids and the endocrine system
Merza Z.
Horm Metab Res. 2010 Aug;42(9):621-6

Abstract

Opioids are widely used for the management of acute and chronic pain. They are also abused for recreational purposes. Long term use may lead to abnormalities in the endocrine system. The axis mainly affected is the gonadal axis leading...
 
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03-03-2011
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Access denied Clinical pharmacology of opioids for pain (2002)
Clin J Pain. (javascript:AL_get(this, 'jour', 'Clin J Pain.') 2002 Jul-Aug;18(4 Suppl):S3-13

Inturrisi CE (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Inturrisi%20CE%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1)
...
 
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Submitted by Jatelka Find all entries from this user
01-03-2008
62.58 Kbytes Hits 131
Keywords: pharmacology opioid
Access denied CNS Drug Delivery: Opioid Peptides and the Blood-Brain Barrier 5 *
Peptides are key regulators in cellular and intercellular physiological responses and possess enormous promise for the treatment of pathological conditions. Opioid peptide activity within the central nervous system (CNS) is of particular
interest for the treatment of pain owing to the elevated...
 
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Submitted by H Bomber Find all entries from this user
08-06-2009
242.05 Kbytes Hits 43
Access denied Cocaine and opioid use during pregnancy: prevalence and management (2008)
Primary Care Companion to the Journal of Clinical Psychiatry

Bhuvaneswar CG (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Bhuvaneswar%20CG%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Chang G...

See also Drug Use Documents  Cocaine & Crack Documents 
 
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09-07-2009
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Access denied Comparing fatal cases involving U-47700 (2016)
Forensic Sci Med Pathol (2016) 12:369–371

Xiulu Ruan, Srinivas Chiravuri, Alan D. Kaye

U-47700 (3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide) is a novel compound with opioid properties, developed by Upjohn in the 1970s and derived from the earlier opioid analgesic AH-7921...
 
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13-10-2016
318.46 Kbytes Hits 5
Access denied Comparison Chart of Heroin Dependence and Agonist Therapies
Nifty little chart, compares Heroin, Methadone, Buprenorphine and LAAM (Levo-Alpha Acetyl Methadol).

Looks at lots of variables including speed of onset, duration, euphoria, tolerance, withdrawal and craving
 
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15-09-2007
265.98 Kbytes Hits 157
Keywords: methadone heroin buprenorphine
Access denied Component analysis of Iranian crack; a newly abused narcotic substance in iran (2014)
  Iranian Journal of Pharmaceutical Research, Vol. 13, Issue 1, Pages 337-344

Ali Farhoudian, Mandana Sadeghi, Hamid Reza Khoddami Vishteh, Babak Moazen, Monir Fekri, Afarin Rahimi Movaghar

Abstract:
Iranian crack is a new form of narcotic substance that has found widespread prevalence in Iran...

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30-07-2014
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Access denied COMPOUNDS POSSESSING MORPHINE-ANTAGONIZING OR POWERFUL ANALGESIC PROPERTIES
Nature. 1965 Apr 3;206:102-3.
BENTLEY KW, BOURA AL, FITZGERALD AE, HARDY DG, MCCOUBREY A, AIKMAN ML, LISTER RE.
 
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11-11-2010
259.39 Kbytes Hits 21
Keywords: cyprenorphine m285 opioid kappa analgesics
Access denied Consensus Statement of an International Expert Panel with Focus on the Six Clinically Most Often Used World Health Organization step III Opioids (Buprenorphine, Fentanyl, Hydromorphone, Methadone, Morphine, Oxycodone) 5 *
Opioids and the Management of
Chronic Severe Pain in the
Elderly: Consensus Statement of
an International Expert Panel
with Focus on the Six Clinically
Most Often Used World Health
Organization step III Opioids
(Buprenorphine, Fentanyl,
Hydromorphone, Methadone,
Morphine, Oxycodone)
 
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11-06-2009
202.83 Kbytes Hits 51
Access denied Cost-Effectiveness of Distributing Naloxone to Heroin Users for Lay Overdose Reversal (2013)
Annals of Internal Medicine. 2013;158:1-9.

Coffin PO, Sullivan SD.

Abstract
Opioid overdose, a major source of morbidity and mortality worldwide, accounts for half of the mortality among heroin users and is a leading cause of death among adults in the United States. Naloxone is a safe,...

See also Heroin Documents 
 
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Submitted by Calliope Find all entries from this user
03-04-2014
2.62 Mbytes Hits 3
Keywords: overdose opioid naloxone heroin
 



 
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