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Downers Documents
Documents about Benzodiazepines, Downers, Sleeping Pills, Z-drugs and Skeletal Muscle Relaxants
New entries announced in forum Downers and sleeping pills
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Access denied A method for screening for various sedative-hypnotics in serum by liquid chromatography/single quadrupole mass spectrometry (2006)
Forensic Science International 2006 Feb 10;157(1):57-70

Miyaguchi H (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Miyaguchi%20H%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Kuwayama K...

See also Drug Testing Documents 
 
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Submitted by Metomni Find all entries from this user
22-10-2008
376.99 Kbytes Hits 51
Access denied A SYNERGISTIC COMBINATION: GABAPENTIN AND PREGABALIN - European Patent EP1196160 5 *
An approved patent application for combining pregabalin and gabapentin. Contains useful information on the relationship between pregabalin and gabapentin, as well as other information such as viable methods of administration for both drugs.  
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Submitted by honourableone Find all entries from this user
06-09-2009
398.17 Kbytes Hits 120
Keywords: gabapentin pregabalin
Access denied Abstinence symptoms after withdrawal from tranquillising drugs; is there a common neurochemical mechanism?
Cowen PJ & Nutt DJ. (1982). Abstinence symptoms after withdrawal from tranquillising drugs; is there a common neurochemical mechanism? Lancet, 2: 360-2.

Abstract: Withdrawal of anxiolytic agents such as ethanol, barbiturates, and benzodiazepines may result in a syndrome characterised in its...

See also Downers Addiction Documents 
 
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Submitted by Bajeda Find all entries from this user
30-06-2009
479.98 Kbytes Hits 36
Keywords: alcohol gaba ethanol benzodiazepines barbituates withdrawal
Access denied Abuse and dependence liability of benzodiazepine-type drugs: GABA(A) receptor modulation and beyond (2008)
Pharmacology Biochemistry and Behaviour 2008 Jul;90(1):74-89

Licata SC (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Licata%20SC%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Rowlett JK...

See also Downers Addiction Documents 
 
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Submitted by Jatelka Find all entries from this user
10-11-2008
506.62 Kbytes Hits 57
Access denied Acute and Chronic Effects of Ramelteon (Rozerem) in Rhesus Monkeys: Dependence Liability studies (2006)
Behav Neurosci. (javascript:AL_get(this, 'jour', 'Behav Neurosci.') 2006 Jun;120(3):535-41

France CP (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22France%20CP%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1), Weltman...
 
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Submitted by Jatelka Find all entries from this user
28-06-2006
106.16 Kbytes Hits 100
Keywords: melatonin ramelteon dependence
Access denied Acute delirium in patients with multiple sclerosis treated with pregabalin
Pregabalin (PGB, Lyrica) is an isomer of gama-aminobutyric acid that is approved as an adjunctive therapy for adult patients with partial seizure. Animal model showed that PGB selectively binds to the alpha2-beta protein of the voltage-gated calcium channels in various central nervous system (CNS)...  
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Submitted by staples Find all entries from this user
31-08-2009
90.49 Kbytes Hits 46
Keywords: pregabalin lyrica
Access denied ALEPH-2, a suspected anxiolytic and putative hallucinogenic phenylisopropylamine derivative, is a 5-HT 2a and 5-HT 2c receptor agonist (2000)
Life Sciences 67 (2000) 3241–3247

Claudio Acuña-Castillo, Cecilia Scorza, Miguel Reyes-Parada, Bruce K. Cassels, J. Pablo Huidobro-Toro

To assess the pharmacodynamic profile of ALEPH-2, a phenylisopropylamine derivative with alleged anxiolytic and hallucinogenic properties, Xenopus laevis...

See also Phenethylamines Documents 
 
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Submitted by ThirdEyeFloond Find all entries from this user
18-01-2008
86.27 Kbytes Hits 103
Keywords: aleph-2
Access denied An effect-size analysis of pharmacologic treatments for generalized anxiety disorder (2007)
J Psychopharmacol. (javascript:AL_get(this, 'jour', 'J Psychopharmacol.') 2007 Nov;21(8):864-72

Hidalgo RB (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Hidalgo%20RB%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus), Tupler...
 
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Submitted by Jatelka Find all entries from this user
27-01-2008
199.72 Kbytes Hits 94
Keywords: anxiety gad
Access denied Anxiolytic-like Effects of 4-Phenyl-2-trichloromethyl-3H-1,5-benzodiazepine Hydrogen Sulphate (PTMB) in Mice (2000)
Braz J Med Biol Res. 2000 Sep;33(9):1069-73

Rubin, M A ; Albach, C A ; Berlese, D B ; Bonacorso, H G ; Bittencourt, S R ; Queiroz, C M ; Maixner, A E ; Mello, C F

The pharmacological effects of 4-phenyl-2-trichloromethyl-3H-1, 5-benzodiazepine hydrogen sulfate (PTMB), a novel synthetic...
 
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Submitted by Jatelka Find all entries from this user
10-05-2007
36.49 Kbytes Hits 88
Keywords: benzodiazepines
Access denied Barbiturate Pharmacology (DeRuiter)
From Jack DeRuiter, Principles of Drug Action 2, Fall 2004  
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Submitted by Jatelka Find all entries from this user
01-12-2006
87.65 Kbytes Hits 1156
Keywords: pharmacology barbiturate
Access denied Barbiturate tolerance: effects on GABA-operated chloride channel function
Allan AM, Zhang X, & Baier LD. (1992). Barbiturate tolerance: effects on GABA-operated chloride channel function. Brain Research, 588(2):255-60.

Abstract: Male ICR mice were fed powdered laboratory chow containing phenobarbital for 7 days to induce tolerance. Mice were sacrificed and brains...
 
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Submitted by Bajeda Find all entries from this user
30-06-2009
753.40 Kbytes Hits 13
Keywords: alcohol phenobarbital ethanol cross-tolerance benzodiazepines tolerance
Access denied Barbiturate-Like Actions of the Propanediol Dicarbamates Felbamate and Meprobamate (1996)
J Pharmacol Exp Ther. 1997 Mar;280(3):1383-91

Rho JM , Donevan SD, Rogawski MA .

Felbamate and meprobamate are structurally related propanediol dicarbamates that possess distinct pharmacological profiles. Felbamate is a minimally sedative, broad-spectrum anticonvulsant, whereas meprobamate...
 
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Submitted by Jatelka Find all entries from this user
12-01-2007
380.98 Kbytes Hits 44
Keywords: meprobamate barbiturate
Access denied Barbiturates and the GABAA receptor complex (1990)
Progress in Drug Research, Volume 34, 1990, Pages 261-286, ISBN 9783034871280

Paul A. Saunders, I. K. Ho

Abstract:
Barbiturates have many effects on the nervous system. Some of the most striking effects of barbiturates are the marked changes they cause in the synapses which use...
 
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Submitted by Behrang Find all entries from this user
20-08-2014
1.09 Mbytes Hits 6
Access denied Basic Mechanisms of Sedative Hyponotics
Chapter from Neuropsychopharmacology: The Fifth Generation of Progress. A Brief history of the discovery of these compounds, also looks at GABA receptors and the effects of theese drugs on various areas of the brain.  
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Submitted by Jatelka Find all entries from this user
01-08-2006
87.50 Kbytes Hits 91
Keywords: pharmacology gaba hypnotics
Access denied Bodyweight gain under pregabalin therapy in epilepsy: mitigation by counseling patients?
Objective:
To evaluate bodyweight gain during pregabalin therapy for epilepsy and the utility of a short counseling program to prevent this side effect.

Methods:
Randomized controlled trial on the effects of extended versus standard patient counseling on the risk of bodyweight gain with 3- and...
 
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Submitted by staples Find all entries from this user
31-08-2009
187.15 Kbytes Hits 49
Keywords: lyrica pregabalin
Access denied Buspirone Data Sheet
Pharmacology, Pharmacokinetics, Indications for use, Overview of research  
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Submitted by Jatelka Find all entries from this user
18-11-2006
79.08 Kbytes Hits 44
Keywords: pharmacology pharmacokinetics buspirone
Access denied Carisoprodol (Soma) Package Insert
Discussion Thread  
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Submitted by Jatelka Find all entries from this user
04-07-2007
138.70 Kbytes Hits 122
Keywords: carisoprodol
Access denied Carisoprodol Abuse In Texas 1998-2003 (2006)
J Med Toxicol. 2006 Mar;2(1):8-13

Forrester MB.


INTRODUCTION: Texas poison centers identified carisoprodol as a skeletal muscle relaxant that is subject to abuse, and this investigation explores the abuse reported by Texas poison centers. METHODS: This study used data from six Texas...
 
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Submitted by Jatelka Find all entries from this user
04-07-2007
128.78 Kbytes Hits 59
Keywords: epidemiology carisoprodol
Access denied Carisoprodol use and abuse in Norway: a pharmacoepidemiological study
British Journal of Clinical Pharmacology 2007 Aug;64(2):210-8

Bramness JG (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Bramness%20JG%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Furu K...

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Submitted by Jatelka Find all entries from this user
06-04-2009
213.48 Kbytes Hits 40
Access denied Carisoprodol: Effects on Human Performance and Behaviour (2003)
Forensic Science Review Vol 15, Number 1, January 2003

Robertson MD and Marietti LJ
 
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Submitted by Jatelka Find all entries from this user
12-01-2007
38.35 Kbytes Hits 61
Keywords: carisoprodol
Access denied Characterisation of the Interaction of Indiplon, a Novel Pyrazolopyrimidine Sedative-Hypnotic, with the GABAa Receptor (2004)
J Pharmacol Exp Ther. (javascript:AL_get(this, 'jour', 'J Pharmacol Exp Ther.') 2004 Nov;311(2):537-46.

Sullivan SK, Petroski RE, Verge G, Gross RS, Foster AC, Grigoriadis DE.

Clinically used benzodiazepine and nonbenzodiazepine sedative-hypnotic agents for the treatment of insomnia...
 
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Submitted by Jatelka Find all entries from this user
12-11-2006
353.05 Kbytes Hits 45
Keywords: indiplon gaba
Access denied Chloral Hydrate Data Sheet
 
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Submitted by Jatelka Find all entries from this user
13-11-2006
29.78 Kbytes Hits 88
Access denied Combined Cannabis/Methaqualone withdrawal treated with psychotropic analgesic nitrous oxide.
This article reports the first single-blind study using psychotropic analgesic nitrous oxide (PAN) for treating acute withdrawal states following the abuse of methaqualone combined and smoked with cannabis. Smoked methaqualone combined with cannabis is called "white pipe" (WP). South Africa is the...

See also Nitrous Oxide (N2O) Documents  Downers Addiction Documents 
 
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Submitted by robin_himself Find all entries from this user
29-10-2008
71.68 Kbytes Hits 37
Access denied Comparative cue generalization profiles of L-838, 417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, zopiclone, and various benzodiazepines in chlordiazepoxide and zolpidem drug discrimination (2006)
Journal of Pharmacology and Experimental Therapeutics 2006 Mar;316(3):1291-9

Mirza NR (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Mirza%20NR%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Rodgers RJ...
 
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Submitted by Jatelka Find all entries from this user
29-10-2008
387.02 Kbytes Hits 29
Access denied Comparative tolerability of newer agents for insomnia (2009)
Drug Safety. 2009;32(9):735-48.
doi: 10.2165/11312920-000000000-00000.

Zammit G.

Abstract
Newer treatment options for insomnia include the non-benzodiazepine hypnotics zolpidem, zolpidem-controlled release, zaleplon, zopiclone, eszopiclone and the melatonin receptor agonist, ramelteon....
 
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Access denied Comparative Tolerability, Pharmacodynamics and Pharmacokinetics of a Metabolite of a Quinilizonone Hypnotic and Zolpidem in Healthy Subjects (2000)
Drug Metab Dispos. (javascript:AL_get(this, 'jour', 'Drug Metab Dispos.') 2000 Dec;28(12):1411-6

Dingemanse J , Bury M , Hussain Y , van Giersbergen P.

The objectives of this double-blind, placebo-controlled study were to assess the single dose tolerability, pharmacodynamics, and...
 
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Submitted by Jatelka Find all entries from this user
15-05-2007
136.05 Kbytes Hits 50
Access denied Cyclobenzaprine HCL Packet Data Sheet
Includes a brief overview of Pharmacology, Pharmacokinetics, Research done, Indications and Usage etc etc

Discussion Thread
 
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Submitted by Jatelka Find all entries from this user
21-06-2007
230.11 Kbytes Hits 52
Keywords: flexeril cyclobenzaprine
Access denied Cytochrome P450 3A-Mediated Metabolism of Buspirone in Human Liver Microsomes (2005)
Drug Metab Dispos. 2005 Apr;33(4):500-7.

Zhu M, Zhao W, Jimenez H , Zhang D , Yeola S , Dai R , Vachharajani N , Mitroka J

This study was carried out to determine the metabolic pathways of buspirone and cytochrome P450 (P450) isoform(s) responsible for buspirone metabolism in human liver...
 
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Submitted by Jatelka Find all entries from this user
09-06-2007
345.09 Kbytes Hits 48
Keywords: metabolism cytochrome buspirone
Access denied Design, synthesis, and preliminary evaluation of gabapentin-pregabalin mutual prodrugs in relieving neuropathic pain.
Shi W, Liu H, Zhang Y, Zhong B, Yang H.
Arch Pharm (Weinheim). 2005 Aug;338(8):358-64.

As a part of a program for the development of specific analgesics in relieving neuropathic pain, the purpose of the present study was to investigate a new concept that involves the conjugation of two drugs,...
 
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Submitted by Paracelsus Find all entries from this user
01-09-2009
100.98 Kbytes Hits 15
Access denied Designer benzodiazepines: a new challenge
In the February 2015 issue of World Psychiatry, Schifano
et al (1) gave an overview of novel psychoactive substances
and their potentially harmful effects. They highlighted that
in the last couple of years the number of drugs offered via
Internet shops has increased dramatically and that benzo-...

See also Research Chemicals Documents  Benzodiazepines Documents 
 
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Submitted by NeuroChi Find all entries from this user
07-11-2015
42.12 Kbytes Hits 7
Keywords: meclonazepam nifoxipam ubromazolam deschloroetizolam clonazolam
Access denied Dissociating anxiolytic and sedative effects of GABAAergic drugs using temperature and locomotor responses to acute stress (2009)
Psychopharmacology (Berl). 2009 Jun;204(2):299-311

Vinkers CH, Klanker M, Groenink L, Korte SM, Cook JM, Van Linn ML, Hopkins SC, Olivier B

RATIONALE: The stress-induced hyperthermia (SIH) model is an anxiety model that uses the transient rise in body temperature in response to acute...
 
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Submitted by Jatelka Find all entries from this user
26-12-2010
1.23 Mbytes Hits 5
Keywords: diazepam zolpidem
Access denied Distinct Actions of Alcohols, Barbiturates and Benzodiazepines on GABA-Activated Chloride Channels
HARRIS, R. A. ALCOHOL 7(3) 273-275, 1990.--

Similarities and differences in the actions of alcohols, barbiturates and benzodiazepines on GABA-activated
chloride channels are reviewed. This question has been approached using behavioral measures, the uptake of 36C1- by isolated brain ...

See also Alcohol Documents  Benzodiazepines Documents 
 
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Submitted by babymakesbeats Find all entries from this user
29-06-2009
587.24 Kbytes Hits 38
Access denied Drug Facts - Newer Unregulated Drugs
ABOUT THIS BRIEFING:
This briefing provides an overview of “Novel Psychoactive Compounds” or “Research Chemicals” in the UK. It is not intended to provide detailed information on each compound or a list of all such compounds. Where substances have become sufficiently popular or enough is known...

See also Research Chemicals Documents  Donating members file area  Drug History Documents  Drug Policy Debate Documents  Law Documents  Drug Culture Documents  Herbal XTC & Smart products Documents  Various drugs not covered by other sections Documents 
 
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Submitted by NeuroChi Find all entries from this user
07-11-2015
1.72 Mbytes Hits 34
Keywords: drone psychoactive designer compounds highs herbal meow chemicals benzo-fury bath drugs mephedrone
Access denied Drugs During Pregnancy and Lactation, 3rd Ed. (Treatment Options and Risk Assessment) - 2.10: Epilepsy and antiepileptic medications (2015)
Drugs During Pregnancy and Lactation, 3rd Ed. (Treatment Options and Risk Assessment)

Edited by: Christof Schaefer, Paul W J Peters, Richard K Miller

ISBN: 978-0-12-408078-2

http://www.sciencedirect.com/science/book/9780124080782
...

See also The Euphoric body Documents  Various drugs not covered by other sections Documents 
 
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Access denied Drugs During Pregnancy and Lactation, 3rd Ed. (Treatment Options and Risk Assessment) - 2.11: Psychotropic drugs (2015)
Drugs During Pregnancy and Lactation, 3rd Ed. (Treatment Options and Risk Assessment)

Edited by: Christof Schaefer, Paul W J Peters, Richard K Miller

ISBN: 978-0-12-408078-2

http://www.sciencedirect.com/science/book/9780124080782
...

See also Benzodiazepines Documents  Z-Drugs Documents  The Euphoric body Documents  Various drugs not covered by other sections Documents  Anti-psychotics Documents  Antidepressants Documents 
 
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Access denied Drugs for sleep disorders: mechanisms and therapeutic prospects (2006)
British Journal of Pharmacology 2006 Jun;61(6):761-6

Szabadi E

The past decade has witnessed an explosion of knowledge about the neural mechanisms that control sleep and arousal, triggered by two discoveries relating to the sleep disorder narcolepsy. Narcolepsy is caused by the loss of...
 
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Submitted by Jatelka Find all entries from this user
12-03-2009
107.77 Kbytes Hits 36
Access denied Early preclinical studies of discriminable sedative and hallucinogenic drug effects
Psychopharmacology (Berl). 2008 Aug 20. [Epub ahead of print]

Barry H 3rd, Appel JB.

RATIONALE: One important technique in behavioral pharmacology is to train laboratory animals to discriminate between a psychoactive drug effect and a nondrug condition. Tests with different drugs have...

See also Hallucinogens in general Documents 
 
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Submitted by ThirdEyeFloond Find all entries from this user
07-09-2008
171.66 Kbytes Hits 69
Access denied Effects of gabapentin and pregabalin on K+-evoked 3H-GABA and 3H-glutamate release from human neocortical synaptosomes.
Brawek B, Löffler M, Weyerbrock A, Feuerstein TJ.
Naunyn Schmiedebergs Arch Pharmacol. 2009 Apr;379(4):361-9. Epub 2008 Nov 11.

One site of action of the anticonvulsant, analgesic, and anxiolytic drugs gabapentin and pregabalin is the alpha(2)delta-subunit of voltage-sensitive Ca(2+) channels...
 
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Submitted by Paracelsus Find all entries from this user
01-09-2009
243.24 Kbytes Hits 6
Access denied Effects of zopiclone and temazepam on sleep, behaviour and mood during the day (1989).
Kleijn, E. (1989). Effects of zopiclone and temazepam on sleep, behaviour and mood during the day. European Journal of Clinical Pharmacology, 36(3), 247-251. doi:10.1007/BF00558155

Summary
Over a 3 week period the hypnotic effect of zopiclone 7.5 rag, temazepam 20 mg and placebo was...

See also Benzodiazepines Documents  Z-Drugs Documents 
 
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Submitted by staples Find all entries from this user
20-12-2011
631.63 Kbytes Hits 6
Keywords: benzodiazepines hypnotics sleep temazepam zopiclone
Access denied Efficacy and Tolerability of Indiplon in Transient Insomnia (2007)
J Clin Sleep Med. (javascript:AL_get(this, 'jour', 'J Clin Sleep Med.') 2007 Jun 15;3(4):374-9.

Rosenberg, Russell ; Roth, Thomas ; Scharf, Martin B ; Lankford, D Alan ; Farber, Robert

OBJECTIVE: The efficacy of indiplon was evaluated by polysomnography (PSG) in an experimental model of...
 
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Submitted by Jatelka Find all entries from this user
13-01-2007
469.67 Kbytes Hits 43
Keywords: indiplon
 



 
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