Documents about Benzodiazepines, Downers, Sleeping Pills, Z-drugs and Skeletal Muscle Relaxants
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Acute delirium in patients with multiple sclerosis treated with pregabalin
Pregabalin (PGB, Lyrica) is an isomer of gama-aminobutyric acid that is approved as an adjunctive therapy for adult patients with partial seizure. Animal model showed that PGB selectively binds to the alpha2-beta protein of the voltage-gated calcium channels in various central nervous system (CNS)...
Anxiolytic-like Effects of 4-Phenyl-2-trichloromethyl-3H-1,5-benzodiazepine Hydrogen Sulphate (PTMB) in Mice (2000)
Braz J Med Biol Res. 2000 Sep;33(9):1069-73
Rubin, M A ; Albach, C A ; Berlese, D B ; Bonacorso, H G ; Bittencourt, S R ; Queiroz, C M ; Maixner, A E ; Mello, C F
The pharmacological effects of 4-phenyl-2-trichloromethyl-3H-1, 5-benzodiazepine hydrogen sulfate (PTMB), a novel synthetic...
Barbiturate tolerance: effects on GABA-operated chloride channel function
Allan AM, Zhang X, & Baier LD. (1992). Barbiturate tolerance: effects on GABA-operated chloride channel function. Brain Research, 588(2):255-60.
Abstract: Male ICR mice were fed powdered laboratory chow containing phenobarbital for 7 days to induce tolerance. Mice were sacrificed and brains...
Barbiturates and the GABAA receptor complex (1990)
Progress in Drug Research, Volume 34, 1990, Pages 261-286, ISBN 9783034871280
Paul A. Saunders, I. K. Ho
Barbiturates have many effects on the nervous system. Some of the most striking effects of barbiturates are the marked changes they cause in the synapses which use...
Basic Mechanisms of Sedative Hyponotics
Chapter from Neuropsychopharmacology: The Fifth Generation of Progress. A Brief history of the discovery of these compounds, also looks at GABA receptors and the effects of theese drugs on various areas of the brain.
Carisoprodol Abuse In Texas 1998-2003 (2006)
J Med Toxicol. 2006 Mar;2(1):8-13
INTRODUCTION: Texas poison centers identified carisoprodol as a skeletal muscle relaxant that is subject to abuse, and this investigation explores the abuse reported by Texas poison centers. METHODS: This study used data from six Texas...
Comparative cue generalization profiles of L-838, 417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, zopiclone, and various benzodiazepines in chlordiazepoxide and zolpidem drug discrimination (2006)
Journal of Pharmacology and Experimental Therapeutics 2006 Mar;316(3):1291-9
Mirza NR (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Mirza%20NR%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Rodgers RJ...
Comparative tolerability of newer agents for insomnia (2009)
Drug Safety. 2009;32(9):735-48.
Newer treatment options for insomnia include the non-benzodiazepine hypnotics zolpidem, zolpidem-controlled release, zaleplon, zopiclone, eszopiclone and the melatonin receptor agonist, ramelteon....
Drugs for sleep disorders: mechanisms and therapeutic prospects (2006)
British Journal of Pharmacology 2006 Jun;61(6):761-6
The past decade has witnessed an explosion of knowledge about the neural mechanisms that control sleep and arousal, triggered by two discoveries relating to the sleep disorder narcolepsy. Narcolepsy is caused by the loss of...
Efficacy and Tolerability of Indiplon in Transient Insomnia (2007)
:AL_get(this, 'jour', 'J Clin Sleep Med.') 2007 Jun 15;3(4):374-9.
Rosenberg, Russell ; Roth, Thomas ; Scharf, Martin B ; Lankford, D Alan ; Farber, Robert
OBJECTIVE: The efficacy of indiplon was evaluated by polysomnography (PSG) in an experimental model of...