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Ecstasy (MDMA, MDEA, MDA) Documents
Documents about MDMA, MDEA, MDA, XTC, E
New entries announced in forum Ecstasy & MDMA
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MDMA History Documents [120 entries]

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Access denied "Partying" hard: party style, motives for and effects of MDMA use at rave parties (2005)
Substance use and Misuse 2005;40(9-10):1479-502

M ter Bogt TF, Engels RC.

This study examines motives for and consequences of MDMA use at different types of dance parties in the Netherlands (2001 and 2002). Participants were 490 visitors of three different types of rave parties,...

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Submitted by Jatelka Find all entries from this user
30-05-2008
138.73 Kbytes Hits 269
Keywords: mdma-use mdma
Access denied "Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA)"
Parker MA, Marona-Lewicka D, Kurrasch D, Shulgin AT, Nichols DE (March 1998)
Journal of Medicinal Chemistry 41 (6): 1001–5. doi:10.1021/jm9705925. PMID*9526575


The three isomeric ring-methylated derivatives of the well-known hallucinogen and entactogen MDA (1a) were synthesized and evaluated...
 
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Submitted by Terrapinzflyer Find all entries from this user
09-09-2010
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Keywords: mda nichols shulgin 5-methyl-mda
Access denied "The Great Unmentionable": Exploring the Pleasures and Benefits of Ecstasy from the Perspectives of Drug Users (2008)
Drugs (Abingdon, England) 2008;15(4):329-349

Hunt G, Evans K

Explores the elements of pleasure in the drug-using experiences of young ecstacy users in the San Fransisco Bay area

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Submitted by Jatelka Find all entries from this user
15-01-2009
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Keywords: mdma-use
Access denied The safety and efficacy of (+/-)3,4-methylenedioxymethamphetamine assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study 4 *
Michael C Mithoefer, Mark T Wagner, Ann T Mithoefer, Lisa Jerome and Rick Doblin

J Psychopharmacol OnlineFirst, published on July 19, 2010 as doi:10.1177/0269881110378371

Abstract
Case reports indicate that psychiatrists administered (+/-)3,4-methylenedioxymethamphetamine (MDMA) as a...
 
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Submitted by Anonymous Find all entries from this user
20-07-2010
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Keywords: mdma psychedelic ptsd therapy
Access denied 'Ecstasy' psychosis and flashbacks.
Br J Psychiatry. 1991 Nov;159:713-5.
Creighton FJ, Black DL, Hyde CE.

Comment in:

* Br J Psychiatry. 1992 Feb;160:276.

Abstract

We report three cases of flashbacks and one case of recurrent psychosis experienced by three MDMA users. We draw the attention of clinicians to the...
 
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Submitted by Anonymous Find all entries from this user
20-11-2010
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Keywords: flashbacks mdma psychosis
Access denied (+)-N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine as a discriminative stimulus in studies of 3,4-methylenedioxy-methamphetamine-like behavioral activity.
J Pharmacol Exp Ther December 1990 255:1098-1106

The stimulus properties of 3,4-methylenedioxymethamphetamine (MDMA)-like compounds were studied in rats trained to discriminate saline from (+)-N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine [(+)-MBDB] hydrochloride (7.18 mumol/kg; 1.75 mg/kg),...
 
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01-04-2010
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Access denied (±)-Nantenine analogs as antagonists at human 5-HT2A receptors: C1 and flexible congeners
Bioorganic & Medicinal Chemistry Letters 19 (2009) 2530–2532
Chaudhary et al.

C1 and flexible analogs of (±)-nantenine were synthesized and evaluated for antagonist activity at human 5-HT2A receptors in a calcium mobilization assay. This work has resulted in the identification of the most...
 
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Submitted by Anonymous Find all entries from this user
20-10-2010
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Keywords: 5-ht2a nantenine mdma antagonist
Access denied 2-Deoxy-D-glucose prevents and nicotinamide potentiates 3, 4-methylenedioxymethamphetamine-induced serotonin neurotoxicity.
2-Deoxy-D-glucose prevents and nicotinamide potentiates 3, 4-methylenedioxymethamphetamine-induced serotonin neurotoxicity.
Isabel Hervías, Berta Lasheras, Norberto Aguirre
Journal of Neurochemistry
Volume 75, Issue 3, pages 982–990, September 2000

Abstract:
Neurotoxicity induced by...

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Submitted by chaos69 Find all entries from this user
20-01-2012
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Keywords: mdma neurotoxicity nicotinamide
Access denied 3,4-Dihydroxymethamphetamine (HHMA). A Major In Vivo MDMA Metabolite in Humans (2001)
Chemical Research in Toxicology 2001 Sep;14(9):1203-8

Segura M, Ortuño J, Farré M, McLure JA, Pujadas M, Pizarro N, Llebaria A, Joglar J, Roset PN, Segura J, de La Torre R.

There is evidence that some heavy users of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) show signs of...
 
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Submitted by Jatelka Find all entries from this user
30-01-2007
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Keywords: mdma
Access denied 3,4-Methylenedioxy analogues of amphetamine: defining the risks to humans (1999)
Neuroscience and Biobehavioural Reviews 1999 Mar;23(4):539-53

Hegadoren KM, Baker GB, Bourin M.

The 3,4-methylenedioxy analogues of amphetamine [MDMA ("Ecstasy", "Adam"), MDA ("Love") and MDE ("Eve")] are recreational drugs that produce feelings of euphoria and energy and a desire to...
 
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Submitted by Jatelka Find all entries from this user
02-09-2009
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Keywords: mda mde mdma
Access denied 3,4-Methylenedioxymethamphetamine (ecstasy) activates skeletal muscle nicotinic acetylcholine receptors (2005)
Journal of Pharmacology and Experimental Therapeutics 2005 Sep;314(3):1267-73

Klingler W, Heffron JJ, Jurkat-Rott K, O'sullivan G, Alt A, Schlesinger F, Bufler J, Lehmann-Horn F

Adverse 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) effects are usually ascribed to neurotransmitter...
 
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11-08-2008
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Access denied 3,4-Methylenedioxymethamphetamine (ecstasy) and alcohol interactions in humans: psychomotor performance, subjective effects, and pharmacokinetics (2002)
Journal of Pharmacology and Experimental Therapeutics 2002 Jan;300(1):236-44

Hernández-López C...
 
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Submitted by Alfa Find all entries from this user
13-06-2006
153.90 Kbytes Hits 75
Keywords: psychomotor interactions pharmacokinetics mdma alcohol
Access denied 3,4-methylenedioxymethamphetamine (ecstasy) inhibits dyskinesia expression and normalizes motor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates (2003)
Journal of Neuroscience 2003 Oct 8;23(27):9107-15

Iravani MM, Jackson MJ, Kuoppamäki M, Smith LA, Jenner P.

Ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] was shown to prolong the action of L-3,4-dihydroxyphenylalanine (L-DOPA) while suppressing dyskinesia in a single patient with...
 
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02-09-2009
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Keywords: dyskinesia l-dopa mdma parkinsonism
Access denied 3,4-Methylenedioxymethamphetamine (MDMA) abuse may cause oxidative stress and potential free radical damage (2003)
Published in Free Radical Research 2003 May;37(5):491-7.

Authors: Jun F. Zhou; Peng Chen; Ye H. Zhou; Liang Zhang; Huai H. Chen

OBJECTIVE: To investigate whether 3,4-methylenedioxymethamphetamine abuse (MDMA abuse) may cause oxidative stress and potential free radical damage in the bodies...
 
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Submitted by ThirdEyeFloond Find all entries from this user
13-01-2008
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Keywords: mdma neurotoxicity
Access denied 3,4-Methylenedioxymethamphetamine (MDMA) Administration to Rats Does Not Decrease Levels of the Serotonin Transporter Protein or Alter its Distribution Between Endosomes and the Plasma Membrane (2005)
JPET Fast Forward. Published on June 7, 2005

Xiaoying Wang, Michael H. Baumann, Heng Xu, Marisela Morales and Richard B. Rothman

We showed that the serotonin (5-HT) neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) reduces brain tissue 5-HT, decreases expression of 5-HT transporter (SERT)...
 
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Submitted by Alfa Find all entries from this user
04-06-2006
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Keywords: mdma serotonin
Access denied 3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions (2001)
Journal of Pharmacology and Experimental Therepeutics Jun;297(3):846-52

Bankson MG, Cunningham KA

(+)-3,4-Methylenedioxymethamphetamine (MDMA; "ecstasy"; "X"; "E") is a popular recreational amphetamine analog that produces a unique set of effects in humans and animals. MDMA use is often...
 
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08-08-2006
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Keywords: serotonin mdma dopamine
Access denied 3,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findings (2007)
Psychopharmacology (Berl) 2007,189(4):407-424

Baumann MH, Wang X, Rothman RB

RATIONALE: 3,4-Methylenedioxymethamphetamine (MDMA) is a widely abused illicit drug. In animals, high-dose administration of MDMA produces deficits in serotonin (5-HT) neurons (e.g., depletion of forebrain 5-HT)...
 
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13-05-2008
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Keywords: mdma neurotoxicity
Access denied 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) and driving impairment (2001)
Journal of Forensic Sciences 2001 Nov;46(6):1426-33

Logan BK, Couper FJ

3,4-Methylenedioxymethamphetamine, or MDMA, is increasing in popularity in the United States as a drug of abuse. It has stimulant and empathogenic mood altering properties with the potential to affect psychomotor skills...
 
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Submitted by Jatelka Find all entries from this user
30-04-2007
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Keywords: mdma
Access denied 3,4-Methylenedioxymethamphetamine induces monoamine release, but not toxicity, when administered centrally at a concentration occurring following a peripherally injected neurotoxic dose (2001)
Psychopharmacology 2001 Mar;154(3):251-60

Esteban B (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Esteban%20B%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), O'Shea E...
 
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Submitted by Bajeda Find all entries from this user
01-10-2007
124.21 Kbytes Hits 46
Keywords: 5-hydroxytryptamine neurotoxicity mdma
Access denied 5-HT2 receptors exert a state-dependent regulation of dopaminergic function: studies with MDL 100,907 and the amphetamine analogue, 3,4-methylenedioxymethamphetamine
Eur J Pharmacol. 1992 Nov 13;223(1):65-74.
Schmidt CJ, Fadayel GM, Sullivan CK, Taylor VL.

Abstract

The highly selective 5-HT2 receptor antagonist, MDL 100,907, was used to explore the role of serotonin in the stimulation of dopaminergic function produced by the amphetamine analogue...
 
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01-12-2010
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Access denied 5-HTTLPR polymorphism, mood disorders and MDMA use in a 3-year follow-up study. (2010)
Martın-Santos, R., Torrens, M., Poudevida, S., Langohr, K., Cuyás, E., Pacifici, R., et al.
Addiction biology, 15(1), 15–22. (2010)

Abstract
A 3-year longitudinal prospective study was conducted to compare the incidence of substance use disorders (SUD) and non-substance use disorders (NSUD)...

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Submitted by staples Find all entries from this user
01-01-2010
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Keywords: cannabis ecstasy mdma
Access denied A behavioural economic analysis of alcohol, amphetamine, cocaine and ecstasy purchases by polysubstance misusers. (2004) 4 *
Drug Alcohol Depend. 2004 Oct 5;76(1):93-9

Harry R. Sumnall, Elizabeth Tyler, Graham F. Wagstaff, Jon C. Cole

Behavioural economic models of substance choice describe the relationship between changes in unit price and consumption. As the majority of UK non-dependent substance misusers are...

See also Cocaine & Crack Documents  Amphetamine Documents  Alcohol Documents  Drug Use Documents 
 
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Submitted by ThirdEyeFloond Find all entries from this user
16-01-2008
103.98 Kbytes Hits 441
Keywords: alcohol amphetamine mdma poly-drug polysubstance
Access denied A Bitter Pill: Overview of Ecstasy (MDMA, MDA) Related Fatalities (2004)
Psychopharmacology 2004 May;173(3-4):242-8

Schifano F

RATIONALE: The issue of ecstasy-related fatalities has extensively attracted the attention of both the media and the general public, but less so of the scientific literature. OBJECTIVES: The aim of the present review is to focus on the...
 
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Submitted by Jatelka Find all entries from this user
30-04-2007
151.44 Kbytes Hits 143
Keywords: mdma mda
Access denied A clash of policy approaches: The rise (and fall?) of Dutch harm reduction policies towards ecstasy consumption (2005)
International Journal of Drug Policy 16 (2005) 65-72

Uitermark and Cohen

This paper describes the origins and evolution of Dutch harm reduction policies towards ecstasy. It is argued that the national government has allowed and supported local stakeholders to experiment with harm reduction...

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10-04-2007
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Keywords: mdma policy ecstasy harm-reduction
Access denied A Clinical Plan For MDMA in the Treatment of Post Traumatic Stress Disorder: Partnering with The FDA (Doblin, 2002)
Originally published in The Journal of Psychoactive Drugs.

"The article presents the rationale behind MAPS (Multi-Disciplinary Association for Psychedelic Studies) efforts to sponsor research... investigating MDMA's effects in PTSD"
 
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07-02-2007
1.87 Mbytes Hits 77
Access denied A Comparative Study on the Acute and Long Term Effects of MDMA and 3,4-dihydroxymethamphetamine (HHMA) on Brain Monoamine Levels After IP or Striatal Administration in Mice (2005)
British Journal of Pharmacology (2005) 144 231-241

Escobedo I, O'Shea E, Orio L, Sanchez V, Segura M, de la Torre R, Farre M, Green AR, Colado MI.

1. This study investigated whether the immediate and long-term effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in mouse brain...
 
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01-02-2007
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Keywords: monoamine mdma
Access denied A comparison of the neurotoxic potential of methylenedioxyamphetamine (MDA) and its N-methylated and N-ethylated derivatives
Eur J Pharmacol. 1987 Feb 10;134(2):245-8.
Stone DM, Johnson M, Hanson GR, Gibb JW.

Abstract

Three psychoactive amphetamine congeners were evaluated for their ability to cause long-term changes in several neurochemical parameters indicative of central serotonergic function. Two weeks after...
 
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02-12-2010
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Keywords: neurotoxicity mdma mda
Access denied A Comparison of the Physiological, Behavioural, Neurochemical and Microglial Effects of Methamphetamine and MDMA in the Mouse (2008)
Neuroscience 2008 Jan 24;151(2):533-43

Fantegrossi WE, Ciullo JR, Wakabayashi KT, De La Garza R 2nd, Traynor JR, Woods JH.

3,4-Methylenedioxymethamphetamine (MDMA) and methamphetamine (METH) are amphetamine analogues with similar persistent neurochemical effects in the mouse which some have...

See also Methamphetamine Documents 
 
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09-01-2008
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Keywords: pharmacology neurotoxicity methamphetamine mdma
Access denied A direct comparison of the behavioral and physiological effects of methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) in humans (2012)
Psychopharmacology (Berl) 2012,219(1):109-122

Kirkpatrick MG, Gunderson EW, Perez AY, Haney M, Foltin RW, Hart CL

RATIONALE: Despite their chemical similarities, methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) produce differing neurochemical and behavioral responses in animals....

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19-05-2013
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Keywords: mdma methamphetamine
Access denied A long hangover from party drugs: residual proteomic changes in the hippocampus of rats 8 weeks after gamma-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination
Neurochem Int. 2010 Jul;56(8):871-7. Epub 2010 Mar 19.
PMID: 20227452
van Nieuwenhuijzen et al.

3,4-Methylenedioxymethamphetamine (MDMA) and g-hydroxybutyrate (GHB) are popular party drugs that are used for their euphoric and prosocial effects, and sometimes in combination. Both drugs...

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10-06-2010
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Keywords: ghb hippocampus mdma proteomics
Access denied A Long-Term Ecstasy Related Change in Visual Perception (2007)
Psychopharmacology 2007 Aug;193(3):437-46

Brown J, Edwards M, McKone E, Ward J.

RATIONALE: The present study provides the first evidence of the long-term consequences of ecstasy use on visual processes thought to reflect serotonergic functions in the occipital lobe....
 
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03-01-2008
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Keywords: mdma
Access denied A method of conducting thereputic sessions with MDMA (1998)
Journal of Psychoactive Drugs 1998 30(4)

Greer and Tolbert

A method for preparing clients and conducting therapeutic sessions with 3,4-methylenedioxymethamphetamine (MDMA) is described, with emphasis on the need for careful attention to the mental set of therapists and clients and the...
 
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19-07-2007
6.46 Mbytes Hits 46
Keywords: therapy mdma
Access denied A Profile of Ecstasy (MDMA) Use in Sao Paulo, Brazil: An Ethnographic Study (2006)
Battisti MC, Noto AR, Nappo S, Carlini Ede A.
J Psychoactive Drugs. 2006 Mar;38(1):13-8.

The use of Ecstasy in Brazil has gained visibility in recent years. Nevertheless, scientific data on this issue remain scarce. The present study focused on clarifying this phenomenon by means of...

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25-02-2010
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Keywords: addiction drug ethnology brazil ethnography pharmacology america
Access denied A Prospective Cohort Study on Sustained Effects of Low-Dose Ecstasy Use on the Brain in New Ecstasy Users (2007)
Neuropsychopharmacology 2007 Feb;32(2):458-70

de Win MM, Reneman L, Jager G, Vlieger EJ, Olabarriaga SD, Lavini C, Bisschops I, Majoie CB, Booij J, den Heeten GJ, van den Brink W

It is debated whether ecstasy use has neurotoxic effects on the human brain and what the effects are of a low...
 
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21-11-2006
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Keywords: mdma
Access denied A prospective study of learning, memory, and executive function in new MDMA users
A prospective study of learning, memory, and executive function in new MDMA users

Addiction 2012 (Early View)

Daniel Wagner, Benjamin Becker, Philip Koester, Euphrosyne Gouzoulis-Mayfrank &
Joerg Daumann

ABSTRACT

Aims It is still unclear if cognitive abnormalities in human...
 
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20-08-2012
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Access denied A randomized, controlled pilot study of MDMA ({+/-}3,4-Methylenedioxymethamphetamine)-assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD) (2012)
J Psychopharmacol 2012,Published online Oct 31

Oehen P, Traber R, Widmer V, Schnyder U.

Psychiatrists and psychotherapists in the US (1970s to 1985) and Switzerland (1988-1993) used MDMA legally as a prescription drug, to enhance the effectiveness of psychotherapy. Early reports suggest that...
 
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19-05-2013
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Keywords: mdma psychotherapy ptsd psychedelic-psychotherapy
Access denied A Review of The Acute Effects of MDMA in Healthy Volunteers (2006)
Journal of Psychopharmacology 2006 Mar;20(2):176-87

Dumont GJ (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Dumont%20GJ%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Verkes RJ...
 
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02-08-2006
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Keywords: mdma
Access denied A role for oxytocin and 5-HT1A receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine (2007)
Neuroscience 2007 May 11;146(2):509-14

Thompson MR, Callaghan PD, Hunt GE, Cornish JL, McGregor IS

The drug 3,4 methylenedioxymethamphetamine (MDMA; ecstasy) has a widely documented ability to increase feelings of love and closeness toward others. The present study investigated whether...
 
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28-04-2007
901.52 Kbytes Hits 56
Keywords: mdma
Access denied A structured review of reasons for ecstasy use and related behaviours: pointers for future research (2009)
BMC Public Health 2009 Jul 13;9:230

Peters GJ, Kok G.

BACKGROUND: While the health risks of using ecstasy warrant intervention development, a recent meta-analysis of determinants of ecstasy use identified a number of lacunae in the literature. Specifically, no studies were included that...

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20-08-2009
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Keywords: mdma-use mdma
Access denied A Study on the Mechanisms by Which Minocycline Protects Against MDMA (‘Ecstasy’)-Induced Neurotoxicity of 5-HT Cortical Neurons
Neurotox Res (2010) 18:187–199
DOI 10.1007/s12640-009-9120-3

Orio et al.

Abstract 3,4-Methylenedioxymethamphetamine (MDMA, ‘ecstasy’) is a selective 5-HT neurotoxin in rat brain which has been shown to produce acute neuroinflammation characterized by activation of microglia and release of...
 
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