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Dissociatives Documents
Documents about DXM, Ketamine, Nitrous Oxide (N2O), PCP
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Access denied A large amount of new designer drug diphenidine coexisting with a synthetic cannabinoid 5-fluoro-AB-PINACA found in a dubious herbal product (2014)
  Forensic Toxicology, Vol. 32, Issue 2, Pages 331-337, Aug.2014

Amin Wurita, Koutaro Hasegawa, Kayoko Minakata, Kanako Watanabe, Osamu Suzuki

Case report


Package of ‘‘ALADDIN SPACIAL EDITION’’ dealt with in this case report

See also Cannabinoids Documents 
 
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Submitted by Behrang Find all entries from this user
04-10-2014
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Access denied A new age of antidepressants: Ketamine and its fast acting effects.
This is a short (500 word) paper i wrote on the subject of ketamine being used in the world of psychology as a fast acting antidepressant with near to no side effects. However, it contains information that can be used for harm reduction. The paper is written to university (BSc Hons) standard and is...

See also Ketamine Documents  Antidepressants Documents 
 
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Submitted by C11H15 Find all entries from this user
28-11-2011
185.91 Kbytes Hits 70
Access denied A study about the synthesis of seven-membered-ring analogues of ketamine (2014)
Research on Chemical Intermediates, Published online: Sep.2014

Abolghasem Moghimi, Mohammad Reza Shahdadi, Sajjad Keshipour, Morteza Sadeghzadeh

Abstract:
Synthesis of seven-membered ring analogues of ketamine was studied with two strategies. In the first approach a sequence of five...

See also Ketamine Documents  Research Chemicals Documents 
 
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Submitted by Behrang Find all entries from this user
25-09-2014
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Access denied ACMD avice on methoxetamine and arylcyclohexylamines
ACMD advice on legislation to control methoxetamine and proposals for a generic "analogue" law for arylcyclohexylamines

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Submitted by davestate Find all entries from this user
21-11-2012
427.39 Kbytes Hits 55
Access denied Acute D2/D3 Dopaminergic Agonism but Chronic D2/D3 Antagonism Prevents NMDA Antagonist Neurotoxicity (2006)
BIOL PSYCHIATRY 2006;60:630–638

Nuri B. Farber, Brian Nemmers, Kevin K. Noguchi

BACKGROUND: Antagonists of the N-methyl-D-aspartate (NMDA) glutamate receptor, most likely by producing disinhibtion in complex circuits, acutely produce psychosis and cognitive disturbances in humans, and...
 
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Submitted by ThirdEyeFloond Find all entries from this user
17-01-2008
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Keywords: nmda dopamine neurotoxicity
Access denied Acute toxicity associated with the recreational use of the ketamine derivative methoxetamine
David M. Wood, Susannah Davies, Malgorzata Puchnarewicz, Atholl Johnston and Paul I. Dargan.

Journal Name: European Journal of Clinical Pharmacology
Publisher: Springer Berlin / Heidelberg
Issn: 0031-6970
Doi: 10.1007/s00228-011-1199-9

Abstract

Purpose
 
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Submitted by Bajeda Find all entries from this user
08-01-2012
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Keywords: methoxetamine toxicity ketamine dissociatives bladder
Access denied Acute toxicity associated with the recreational use of the ketamine derivative methoxetamine
"Long-term regular use of ketamine has been reported to be associated with severe symptomatic urinary tract problems. Methoxetamine, an arylcyclohexylamine derivative of ketamine, is marketed as a “bladder safe” derivative of ketamine, and no cases of acute toxicity following analytically confirmed...  
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Submitted by enquirewithin Find all entries from this user
25-03-2012
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Keywords: bladder ketamine methoxetamine arylcyclohexylamine
Access denied Acute toxicity associated with the recreational use of the ketamine derivative methoxetamine
David M. Wood & Susannah Davies & Malgorzata Puchnarewicz & Atholl Johnston & Paul I. Dargan

Abstract
PURPOSE:
Long-term regular use of ketamine has been reported to be associated with severe symptomatic urinary tract problems. Methoxetamine, an arylcyclohexylamine derivative of ketamine, is...

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Submitted by Gradient Find all entries from this user
25-04-2012
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Keywords: methoxetamine mxe
Access denied Age-Specific Neurotoxicity in the Rat Associated with NMDA Receptor Blockade: Potential Relevance to Schizophrenia? (1995)
BIOL PSYCHIATRY 1995;38:788-796

Nuri B. Farber, David F. Wozniak, Madelon T. Price, Joann Labruyere, Janice Huss, Heidi St. Peter, and John W. Olney

Agents that block the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor induce a schizophrenialike psychosis in adult humans and...
 
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Submitted by ThirdEyeFloond Find all entries from this user
17-01-2008
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Keywords: neurotoxicity nmda
Access denied Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism (2004)
American Journal of Psychiatry 2004 Oct;161(10):1776-82.

Petrakis IL, Limoncelli D, Gueorguieva R, Jatlow P, Boutros NN, Trevisan L, Gelernter J, Krystal JH.

OBJECTIVE: A family history of alcoholism is a risk factor for the development of ethanol dependence. Ethanol is an antagonist of...

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Submitted by Paracelsus Find all entries from this user
13-11-2007
1.88 Mbytes Hits 80
Keywords: ketamine addiction alcoholism
Access denied Antiepileptic drugs and agents that inhibit voltage-gated sodium channels prevent NMDA antagonist neurotoxicity (2002)
Molecular Psychiatry [2002] 7, 72&-733

NB Farber, X-P Jiang, C Heinkel and B Nemmers

N-methyl-D-aspartate (NMDA) glutamate receptor antagonists are used in clinical anesthesia and are being developed as therapeutic agents for preventing neurodegeneration in stroke, epilepsy, and brain...
 
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Submitted by ThirdEyeFloond Find all entries from this user
17-01-2008
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Keywords: neurotoxicity nmda
Access denied Antioxidants attenuate MK-801-induced cortical neurotoxicity in the rat (CL. Willis et al. 2006)
NeuroToxicology 28 (2007) 161–167

Colin L. Willis, David E. Ray

Oxidative stress has been implicated in the pathogenesis of several neurodegenerative diseases and may result from excessive free radical production due to increased local metabolism. Non-competitive N-methyl-D-aspartate (NMDA)...
 
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Submitted by ThirdEyeFloond Find all entries from this user
17-01-2008
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Keywords: mk-801 neurotoxicity
Access denied Assessment of the effect of dextromethorphan and ketamine on the acute nociceptive threshold and wind-up of the second pain response in healthy male volunteers.
Hughes AM, Rhodes J, Fisher G, Sellers M, Growcott JW. British Journal of Clinical Pharmacology 2002 Jun;53(6):604-612.

AIMS: The aim of this study was to assess the efficacy of dextromethorphan and ketamine relative to placebo on the acute nociceptive threshold and wind-up of second pain...
 
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21-10-2007
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Access denied Autoradiographic study on the pharmacological characteristics of [3H]3-OH-PCP binding sites in rat brain (1996)
Authors: Toshihito Suzuki, Toshifumi Yamamoto, Takafumi Hori, Atsuomi Baba, Hiroyasu Shiraishi, Takehiko Ito, John E. Piletz, Ing Kang Ho

Abstract: The pharmacological characteristics and the regional distribution of [3H]3-OH-PCP (l-[l(3-hydroxyphenyl)-cyclohexyl]piperidine) binding were...
 
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Submitted by Mersann Find all entries from this user
06-06-2012
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Access denied Characterizing metabolites and potential metabolic pathways for the novel psychoactive substance methoxetamine (2013)
Drug Testing and Analysis, Vol. 6, Issue 6, Pages 506–515, Jun.2014

E. L. Menzies, S. C. Hudson, P. I. Dargan, M. C. Parkin, D. M. Wood, A. T. Kicman

Abstract:
The classic approach of controlled volunteer studies to study drug metabolism is difficult or impossible to undertake for novel...
 
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06-10-2014
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Access denied Drugs During Pregnancy and Lactation, 3rd Ed. (Treatment Options and Risk Assessment) - 2.21: Recreational drugs (2015)
Drugs During Pregnancy and Lactation, 3rd Ed. (Treatment Options and Risk Assessment)

Edited by: Christof Schaefer, Paul W J Peters, Richard K Miller

ISBN: 978-0-12-408078-2

http://www.sciencedirect.com/science/book/9780124080782
...

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Access denied Effect of Age and Sex on N-Methyl-D-Aspartate Antagonist-Induced Neuronal Necrosis in Rats (1996)
Stroke. 1996;27:743-746.

Roland N. Auer, MD, PhD

BACKGROUND AND PURPOSE: Although N-methyl-D-aspartate (NMDA) antagonism may be a useful therapeutic approach in stroke treatment, it has been found that these pharmacological agents cause neuronal necrosis in restricted cortical regions of...
 
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Submitted by ThirdEyeFloond Find all entries from this user
17-01-2008
249.08 Kbytes Hits 37
Keywords: nmda neurotoxicity
Access denied Effects of NMDA receptor antagonists and sigma ligands on the acquisition of conditioned fear in mice (1991)
Psychopharmacology 1991;104(1):27-34.

Sanger DJ (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Sanger%20DJ%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Joly D...

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Submitted by Bajeda Find all entries from this user
06-07-2007
1015.55 Kbytes Hits 35
Keywords: nmda memory learning
Access denied EMCDDA–Europol Joint Report on a new psychoactive substance: methoxetamine (2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone) (2014)
In accordance with Article 5 of Council Decision 2005/387/JHA on the information exchange, risk assessment and control of new psychoactive substances

ISSN: 1977-7868
 
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Submitted by Behrang Find all entries from this user
11-10-2014
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Access denied From "Special K" to "Special M": the evolution of the recreational use of ketamine and methoxetamine (2013)
CNS Neuroscience & Therapeutics (Special Issue: Ketamine Revisited), Vol. 19, Issue 6, Pages 454–460, Jun.2013

Ornella Corazza, Sulaf Assi, Fabrizio Schifano

Summary:
This article reviews the recreational use of ketamine ("Special K"; KET) and explores the recent diffusion of its new...
 
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06-10-2014
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Access denied From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs (2014)
Drug Testing and Analysis (Special Issue: New psychoactive substances part II), Vol. 6, Issue 7-8, Pages 614–632, Jul-Aug.2014

Hamilton Morris, Jason Wallach

Abstract:
PCP or phencyclidine was discovered in 1956 and soon became a popular street drug. Dissociatives including PCP, ketamine,...
 
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04-10-2014
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Access denied Here today, gone tomorrow…and back again? A review of herbal marijuana alternatives (K2, Spice), synthetic cathinones (bath salts), kratom, Salvia divinorum, methoxetamine, and piperazines (2012)
Journal of Medical Toxicology, Vol. 8, Issue 1, Mar/2012, Pages 15-32

Christopher D. Rosenbaum, Stephanie P. Carreiro, Kavita M. Babu

Abstract:
Despite their widespread Internet availability and use, many of the new drugs of abuse remain unfamiliar to health care providers. The herbal...

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Submitted by Behrang Find all entries from this user
26-07-2014
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Access denied In the adult CNS, ethanol prevents rather than produces NMDA antagonist-induced neurotoxicity.
Farber NB, Heinkel C, Dribben WH, Nemmers B, Jiang X.

Brain Res. 2004 Nov 26;1028(1):66-74.

Abstract:
Single doses of an NMDA antagonist cause an adult or a prepubertal form of neurodegeneration, depending on the age of the animal. Single doses of ethanol (EtOH) by blocking NMDA receptors...
 
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Submitted by Salvinorin A Find all entries from this user
15-01-2010
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Access denied Ketamine-derived designer drug methoxetamine: metabolism including isoenzyme kinetics and toxicological detectability using GC-MS and LC-(HR-)MSn (2013)
Analytical and Bioanalytical Chemistry, Vol. 405, Issue 19, Jul/2013, Pages 6307-6321

Markus R. Meyer, Martina Bach, Jessica Welter, Michael Bovens, Alain Turcant, Hans H. Maurer

Abstract:
Methoxetamine (MXE; 2-(3-methoxyphenyl)-2-(N-ethylamino)-cyclohexanone), a ketamine analog, is a new...
 
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24-07-2014
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Access denied Ketamine-derived designer drug methoxetamine: metabolism including isoenzyme kinetics and toxicological detectability using GC-MS and LC-(HR-)MSn - Electronic Supplementary Material (2013)
 
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24-07-2014
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Access denied Ketamine-like Effects After Recreational Use of Methoxetamine
  Methoxetamine, the N-ethyl derivative of ketamine, is a novel recreational drug that is not at present subject to restrictive regulations in most countries. To our knowledge, no case of methoxetamine abuse has been published to date in the scientific literature, and the only sources of information...

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Submitted by enquirewithin Find all entries from this user
19-09-2012
222.56 Kbytes Hits 24
Keywords: mxe mdma methoxetamine
Access denied Methoxetamine (MXE) – A Phenomenological Study of Experiences Induced by a “Legal High” from the Internet (2013)
Journal of Psychoactive Drugs, Vol. 45, Issue 3, 2013, Pages 276-286

Anette Kjellgren, Kristoffer Jonsson

Abstract:
Methoxetamine (MXE), a ketamine analogue, is one of the new “legal highs” sold on the Internet. The aim of this qualitative study was to provide an initial understanding of...
 
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11-10-2014
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Access denied Methoxetamine - a novel recreational drug with potent hallucinogenic properties (2014)
Toxicology Letters, Available online 13.Aug.2014, In Press, Uncorrected Proof

Jolanta B. Zawilska

Abstract:
Methoxetamine is one of the constantly growing group of novel psychoactive substances that has emerged in recent years. The compound belongs to the arylcyclohexylamine class, which is...
 
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14-09-2014
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Access denied Methoxetamine associated reversible cerebellar toxicity: Three cases with analytical confirmation
Methoxetamine associated reversible cerebellar toxicity: Three cases with analytical confirmation (2012)

Clinical Toxicology (Phila). 2012 Jun;50(5):438-40

Jennifer E. Shields, Paul .J. Dargan, David M. Wood , Malgorzata Puchnarewicz,Susannah Davies, and W. Stephen Waring

There have been...

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Submitted by Calliope Find all entries from this user
17-07-2012
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Keywords: toxicity mxe methoxetamine
Access denied Methoxetamine monograph
This monograph provides basic chemical/physical data and along with Gas Chromatography (GC), Mass Spectrometry (MS), Infrared spectra (FT IR), Nuclear Magnetic Resonance (NMR) analyses of MXE (methoxetamine).

Source : http://www.swgdrug.org/monographs.htm
 
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Submitted by John_bob Find all entries from this user
07-12-2014
511.13 Kbytes Hits 5
Keywords: mxe monograph methoxetamine data chemistry chemical analysis
Access denied Methoxetamine: a novel ketamine analog and growing health-care concern
  A report from the US about a case of MXE in a healthcare setting in the US. People should be careful. This is the type of situation which leads to bans.  
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Submitted by enquirewithin Find all entries from this user
28-11-2011
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Access denied Methoxetamine: from drug of abuse to rapid-acting antidepressant (2012)
Medical Hypotheses, Vol. 79, Issue 4, Pages 504–507, Oct.2012

M. Coppola, R. Mondola

Abstract:
Methoxetamine is a dissociative anaesthetic showing pharmacodynamic similarities with its analogue ketamine, a medication with demonstrated rapid-acting antidepressant effects. Like ketamine and...
 
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14-09-2014
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Access denied Methoxetamine: Harm Reduction Advice 3 *
  Harm Reduction Advice from ACMD, UK

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Submitted by enquirewithin Find all entries from this user
19-09-2012
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Keywords: mxe acmd methoxetamine
Access denied Muscimol prevents NMDA antagonist neurotoxicity by activating GABAA receptors in several brain regions (2003)
Brain Research 993 (2003) 90–100

Nuri B. Farber, Xiaoping Jiang, Krikor Dikranian, Brian Nemmers

N-Methyl-D-aspartate (NMDA) glutamate receptor antagonists are being developed as therapeutic agents for several clinical conditions. However, the ability of these agents to produce...
 
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16-01-2008
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Keywords: nmda neurotoxicity
Access denied Neuroprotective and neurotoxic properties of the 'inert' gas, xenon
Ma D, Wilhelm S, Maze M, Franks NP. British Journal of Anaesthesia 2002;89(5):739-46.

BACKGROUND: Antagonists of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors have been shown not only to have neuroprotective effects but also to exhibit neurotoxic properties. In this study, we...
 
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13-11-2007
276.45 Kbytes Hits 95
Keywords: neuroprotection xenon
Access denied Neuropsychotoxicity of abused drugs: potential of dextromethorphan and novel neuroprotective analogs of dextromethorphan with improved safety profiles in terms of abuse and neuroprotective effects
Shin EJ, Lee PH, Kim HJ, Nabeshima T, Kim HC. Journal of Pharmacological Sciences 2008 Jan;106(1):22-7.

Drug abuse involving dextromethorphan, an antitussive, has been a social problem in various geographic locations since the 1960s. Ironically, high doses of the drug confer neuroprotective...

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Submitted by ThirdEyeFloond Find all entries from this user
21-01-2008
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Keywords: dxm
Access denied NMDA Receptor Antagonists Disinhibit Rat Posterior Cingulate and Retrosplenial Cortices: A Potential Mechanism of Neurotoxicity (2002)
The Journal of Neuroscience, April 15, 2002, 22(8):3070–3080

Qiang Li, Suzanne Clark, Darrell V. Lewis, and Wilkie A. Wilson

NMDA receptor antagonists produce region-specific neurodegeneration by an undetermined mechanism, but one proposed mechanism involves disinhibition. In certain areas...
 
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16-01-2008
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Keywords: nmda neurotoxicity
Access denied Novel Psychoactive Substances: How to Understand the Acute Toxicity Associated With the Use of These Substances
Novel Psychoactive Substances: How to Understand the Acute Toxicity Associated With the Use of These Substances (2012)


Therapeutic Drug (https://drugs-forum.com/forum/showwiki.php?title=Drug) Monitoring. 2012 Aug;34(4):363-7.

David M. Wood, MD, MRCP (UK), FBPharmacolS and Paul I....

See also Research Chemicals Documents  Mephedrone & other Beta-ketones Documents  Piperazines Documents  Cannabinoids Documents 
 
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Submitted by Calliope Find all entries from this user
17-07-2012
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Keywords: toxicity methoxetamine mephedrone highs dissociatives cannabinoids
Access denied Ontogeny of the N-Methyl-D-Aspartate (NMDA) Receptor System and Susceptibility to Neurotoxicity (2002)
TOXICOLOGICAL SCIENCES 68, 9–17 (2002)

Kathleen A. Haberny, Merle G. Paule, Andrew C. Scallet, Frank D. Sistare, David S. Lester, Joseph P. Hanig and William Slikker, Jr.

The NMDA receptor has been widely investigated in recent years as a target for the pharmacological management of...
 
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16-01-2008
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Keywords: nmda neurotoxicity
Access denied Paradoxical effects of very low dose MK-801 (2006)
European Journal of Pharmacology 537 (2006) 77–84

Yuanjia Tang, Hong Zou, Judith A. Strong, Yiwen Cui, Qinglian Xie, Guoping Zhao, Meilei Jin, Lei Yu

Systemic injection of the noncompetitive NMDA (N-methyl-D-aspartate) receptor antagonist MK-801 (dizocilpine maleate) is known to cause...
 
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Submitted by ThirdEyeFloond Find all entries from this user
23-01-2008
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Keywords: mk-801
 



 
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