Originally Posted by Emin
I saw this about a month ago, I'm considering asking my doctor about getting some. To me, it makes more sense to make a zaleplon
sublingual formulation because of the short half-life
While Zaleplon isn't specifically approved for middle-of-the-night awakenings, it is noted throughout literature on the nonbenzodiazepines that zaleplon's short duration implicates its use for this purpose, and its maximum recommended daily dose of 20mg allows doctors to easily prescribe enough for the patient to use it in the middle of the night if necessary. In other words: short of achieving on-label use, zaleplon in its oral formulation is already considered and appropriate agent for middle-of-the-night awakenings (at least in the US).
I was particularly excited to find out that zaleplon could be used this way, but unfortunately I was disappointed with zaleplon's efficacy (or, lack thereof). That is why I was happy to come across this new formulation of zolpidem
. However, if you have found zaleplon effective and would like to use it for middle-of-the-night awakenings, your doctor may be happy to prescribe it for such (or s/he may not be familiar with this usage, in which case, you should use your discretion regarding finding a more specialized doctor or bringing this use to your current doctor's attention). I've uploaded the following (and there should be other papers/reviews already in the archive which mention this usage, but I'm sure I can find more if there aren't): Zaleplon: A Review of its Use in the Treatment of Insomnia.
Originally Posted by Zaleplon: A Review of its Use in the Treatment of Insomnia
The pharmacokinetic profile of zaleplon (short t˝β and lack of active metabolites) makes this drug particularly well suited for patients with sleep onset insomnia. Its short duration of action and its rapid absorption enables zaleplon to be used on an ‘as needed’ basis. Thus, the patient does not have to predict which nights insomnia is likely to occur and can control administration of the drug. In addition, because of its lack of next-day effects, zaleplon is useful for middle-of-the-night administration as long as patients then receive at least 4 hours sleep after taking the dose.
Thanks for the link!