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  #1  
Old 24-12-2009, 06:54
Nnizzle Nnizzle is offline
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Oxycodone FAQ

Oxycodone FAQ

Oxycodone is an opioid. It is synthesized from thebaine which is an alkaloid found in opium from poppy plants. It is used most commonly for the treatment of moderate acute and chronic pain.

OxyContin vs Roxicodone vs Oxycodone

There is a lot of confusion about Oxycontin particularly, I assume because the name is so similar to oxycodone. Oxycontin is not a drug, it is a brand name for a preparation of oxycodone. Oxycodone is the active chemical in oxycontin, the rest is fillers (otherwise some pills would be tiny), binders, or substances which create the time-release mechanism. The same goes for Roxicodone, and other common preparations. Some preparations, such as Percocet, also contain acetaminophen to prevent abuse or supposedly to help pain relief, although my dog does not count on acetaminophen to help treat anything.

IR vs CR


OxyIR is oxycodone hydrochloride and fillers/binders. It is designed for acute treatment of pain, and is an immediate release formulation, meaning as soon as it is ingested it goes to work. OxyContin is designed for longer lasting analgesia, releasing the drug over a period of about 12 hours. It contains an outer colored coating, which, contrary to popular belief, is not the time release mechanism. The colored coating is just a system so that ingredients can be easily recognized. The time release mechanism is a wax matrix inside which "suspends" the oxycodone. Even after removing the coating, the pill must be crushed to defeat the mechanism to make it suitable for insufflation or injecting.

Injecting oxycodone

Unless swiy is getting lab grade, pure oxycodone, it is highly inadvisable to inject products which contain anything besides oxycodone hydrochloride (or another suitable salt, my dog doesn't know of any pharmaceuticals which don't contain the hydrochloride salt). If one does have pure oxycodone, it is quite simple to inject it, however keep in mind that even generic, instant release versions of oxycodone will likely contain inert binders or fillers even if they don't contain any other active ingredients. It is dangerous to inject these ingredients. If one is intent on injecting, it is fairly simple. The process, like injecting other drugs, involves creating a solution containing the oxycodone and preparing it for injection. There is a great thread called Injecting Basics which can be of great use, as well as a thread specifically about preparing oxycodone hydrochloride for injection here. To inject OxyContin, the coating must be removed. A great process is described here.

Preparations


Oxycodone comes in a variety of forms:
OxyIR (oxycodone hydrochloride): 5 mg, 10 mg, 20 mg (Canada)
OxyContin (oxycodone hydrochloride and time release mechanism): 5 mg (blue, only available in Canada and the UK), 10 mg (white, Canada, US, UK), 15 mg (grey, US), 20 mg (pink, Canada, US, UK), 30 mg (brown, US), 40 mg (tan, Canada, US, UK), 60 mg (red, US), and 80 mg (green, Canada, US, UK), 160 mg used to be available but was taken off shelves due to a few accidental deaths and because of "diversion" problems.
Roxicodone (generic oxycodone hydrochloride): 5 mg (white, recently ceased), 15 mg (green), 30 mg (blue); 5mg/5ml oral solution; 20mg/ml concentrate
Percocet (oxycodone hydrochloride/acetaminophen, Canada and US): 2.5 mg/325 mg (pink oval), 5 mg/325 mg (blue round), 7.5 mg/325 mg (peach oval), 7.5mg/500 mg (peach capsule-shaped), 10 mg/325 mg (yellow capsule-shaped), 10 mg/650 mg (yellow oval), 10 mg/1000 mg (blue oval)
Percodan (oxycodone hydrochloride/aspirin, US only): 5 mg/325 mg
OxyNorm (oxycodone hydrochloride solution): 5, 10, or 20 mg capsules; 5 mg/5 ml, 250 ml bottles (Australia, NZ, UK), 10mg/ml and 50mg/ml injection solution (NZ, UK)
Depalgos (oxycodone hydrochloride/acetaminophen, Italy): 5 (yellow), 10 (pink), and 20 (red) mg/325 mg

Relative strength


Oxycodone is about 1.5-2 times as strong as morphine. Science says that oxycodone is about 1.5 times as strong as hydrocodone, but in my dog's experience they have been pretty much the same. Others swear oxycodone is stronger.

Tolerance


Oxycodone users can develop a tolerance to the drug just like users of other opiates/opioids. Tolerance is heavily dependent on frequency of use, length of use, dose, and many factors unique to individuals. Oxycodone is cross-tolerant with basically all other opiates/opioids.

Combinations

Oxycodone, as an opioid, should not be combined with other opiates/opioids, benzodiazepines, alcohol, or any other drugs which have an inhibiting effect. Oxycodone causes respiratory depression, combining it with other drugs which do the same can have serious consequences, possibly respiratory failure and possible overdose and/or death.

Dosage

For the opiate intolerant, 5 mg is generally a no-risk dose. Many people might not get much euphoria off of 5 mg, but it is important to start as low as possible if one has no tolerance and/or has never had an opiate experience. For most people, 10-15 mg will produce noticeable euphoria, sedation, etc. (all the good stuff). Anywhere above 15 mg for a first timer might be overwhelming. Taking too much of an opioid can induce nausea. For the opiate tolerant, one must decide for themselves, as individual tolerances vary greatly.

Routes of administration

Oxycodone can be administered orally, intravenously, rectally, sublingually, rectally, or via insufflation. Oxycodone is unique as it is an opioid with relatively high oral bioavailability (the amount of a drug which reaches the brain).

Bioavailability

Oral:
60-87%
Intranasal: 46% +/- 34%
IV: for all intensive purposes, 100%
Rectal: 61% +/- 30%
Sublingual: 45.4% +/- 20.1%

Intranasal, rectal, and sublingual will hit faster than oral, and IV will obviously hit the fastest. Insufflation of oxycodone, especially oxycodone prepared with other substances, can cause damage to the nasal mucosa. Injecting fillers/binders can cause a multitude of bad things. It is safest to take oxycodone orally.

Pharmacology


For information on how oxycodone produces a high, please see the thread Pharmacology of Common Recreational Drugs.

Primary effects

Oxycodone, as a recreational drug, is usually used to achieve the euphoria characteristic of opiates. Other positive effects include relaxation, sedation, anxyiolysis, and analgesia. If swiy doesn't feel these effects at a common dose, he is either naturally tolerant to oxycodone, has built a tolerance from other opioid use, ate too much beforehand, etc. Experiences vary, talk to your doctor if you are really interested in why you don't feel what you are supposed to feel.

Common neutral or adverse side effects

Miosis (pupil constriction)
Sweating
Slowed reaction time
Focus and attention problems
Loss of appetite
Constipation (dose and frequency dependent)
Nausea/vomiting (can be attenuated with cannabis or an antiemetic)
Dizziness
Itching
Dry mouth
Fatigue
Insomnia

Potentiation


Oxycodone can be potentiated the same way that other opiates/opioids can. A very comprehensive thread about potentiation can be found here.

Drug test

Oxycodone will not test positive on a drug test which tests for opiates. A separate test designed for opioids such as oxycodone is needed, although nowadays oxycodone abuse is quite well known and it is likely that if one is suspected of opiate use, they will also be tested for oxycodone.

Please add info concerning oxycodone here.

Post Quality Evaluations:
great contribution!
uoght to be a sticky.
Awesome FAQ!
very detailed
Much appreciated!
So much accurate information
  #2  
Old 25-12-2009, 05:28
NeuroChi NeuroChi is offline
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Re: Oxycodone FAQ

Excellent article nnizzle, could you put this in the wiki format and create a new article for Oxycodone?
A list of sources of information would be good as well.
  #3  
Old 25-12-2009, 17:07
desertimplant desertimplant is offline
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Re: Oxycodone FAQ

SWIM has noticed nnizzle has done a great job starting experience\how-to\info threads on most of the more popular opiates. Hopefully many more will chime in and add to these threads. Once they get more filled out they pretty much should answer 99.9% of any questions\concerns\possible problems related to any popular opiate in use currently...nice work Nnizzle
  #4  
Old 12-05-2013, 01:03
abagailadams abagailadams is offline
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Re: Oxycodone FAQ

I think you left out 10mg Roxicodone (pink).


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