Drugs-Forum  
Home Wiki Studies Forum Groups Blog Video Images News
Go Back   Drugs Forum > DRUG-FORUMS > Various drugs not covered by other forums > Antipsychotics
Mark Forums Read
Register Tags

Notices

 
Thread Tools
  #1  
Old 01-01-2010, 20:07
OrbitalSPIN OrbitalSPIN is offline
Account Awaiting Email Confirmation.
 
Join Date: 16-08-2009
33 y/o Male from United States
Posts: 39
OrbitalSPIN is learning how to become a psychonaut.
Points: 66, Level: 1 Points: 66, Level: 1 Points: 66, Level: 1
Activity: 0% Activity: 0% Activity: 0%
Loxapine : More of an atypical or typical antipsychotic ?

As a hobbie and for pesonal reasons SWIM researches Pharmaceuticals. One in particular has caught SWIMs attention. It is an antipsychotic called Loxapine, Its a member of the Dibenzoxazepine class, its chemical structure is 2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f] [1,4]oxazepine. Its structurally related to Clozapine and it has antidepressant effects. When Loxapine is metabolized in the body some of it is metabolized by N-demethylation to Amoxapine, a tricyclic antidepressant. Its been argued amoung many Pharmaceutical researchers and some Doctors that Loxapine behaves more like an atypical antipsychotic than a typical antipsychotic. SWIM agrees with this notion of Loxapine being an atypical and thinks that this medication should be given a second look to treat some Psychiatric problems. Question#1: Although Loxapine is classified as a typical antipsychotic does a FOAF think its more of an atypical antipsychotic ? Question#2: Does a FOAF think that this medication should be given a second look amoung Pharmaceutical researchers and Doctors ?

Post Quality Evaluations:
well stated question on loxapine
  #2  
Old 02-01-2010, 22:02
chibi curmudgeon chibi curmudgeon is offline
Gold Finger
 
Join Date: 26-11-2008
34 y/o Female from United States
Posts: 1,420
chibi curmudgeon must mainline Medlinechibi curmudgeon must mainline Medlinechibi curmudgeon must mainline Medlinechibi curmudgeon must mainline Medlinechibi curmudgeon must mainline Medlinechibi curmudgeon must mainline Medlinechibi curmudgeon must mainline Medlinechibi curmudgeon must mainline Medlinechibi curmudgeon must mainline Medlinechibi curmudgeon must mainline Medlinechibi curmudgeon must mainline Medline
Points: 2,537, Level: 7 Points: 2,537, Level: 7 Points: 2,537, Level: 7
Activity: 1.3% Activity: 1.3% Activity: 1.3%
Re: Loxapine : More of an atypical or typical antipsychotic ?

Loxapine kind of sucks. Based on the side effect profile, I'd consider it a typical AP, though iirc it's closer to clozapine than, say, haloperidol. It's possible I'm confusing it with something else, though.

My humble opinion is that clozapine isn't that bad, as long as one doesn't have a problem with weight gain or white blood cells, and I wouldn't consider it last-line therapy. But loxapine has all of the dyskinetic, NMS, hyperprolactin type crap going on, and I'd place it in the last resort category.

I don't think I've ever seen it prescribed, and in class it wasn't even brought up. Typical or not, it's one of the crappier APs.

Post Quality Evaluations:
accurate reply well put

Share this on:

Tags
antipsychotic comparison, loxapine

Thread Tools


» New Threads
DXM Entertainment - Things to watch
Last post by Meth Orphan
19 Replies, 1,629 Views
DXM Drug Test? WTF.
Last post by Rob Cypher
4 Replies, 173 Views
Hydromorphone help please??
Last post by whatthedillie
8 Replies, 349 Views
Ohio mom allowed dealer to...
Last post by Rob Cypher
0 Replies, 9 Views
Rutgers University (NJ) student...
Last post by Rob Cypher
0 Replies, 10 Views
question : why do people drink...
Last post by Ewald
3 Replies, 135 Views
Science behind Hydrocodone on drug...
Last post by talula509
0 Replies, 24 Views
4-fluoro-alpha-PVP (pFPVP) Drug...
Last post by Rob Cypher
14 Replies, 7,767 Views
Fellow Tweakers. What is it that...
Last post by tweakerangel
59 Replies, 10,006 Views
Drinking Alone
Last post by JR88
35 Replies, 3,626 Views
» New Wiki Articles

Sitelinks: Information:

All times are GMT +1. The time now is 06:51.


Copyright: SIN Foundation 2003 - 2014, All rights reserved