Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 3 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
This question comes from SWIM who happens to have legal prescriptions for both. Last night he took one 50mg tramadol for a moderate tension headache. About 30 mins later, he took 5mg dexmethylphenidate (generic Focalin). The effects were surprising!
SWIM will take a therapeutic dose of up to 40mg of focalin a day. After 3 years, he's built a bit of a tolerance and is VERY used to the effects. He's also been taking Tramadol, on occasion, for the last year or so, and enjoys the mild stimulant effects that accompany the VERY mild opioid euphoria.
Last night was totally different. In a lot of ways, it felt like the first time SWIM ever tried Focalin, but longer-lasting: Energy, focus, physical stamina, positive mood shift, etc. Not overwhelming. Not that "tweaked" feeling. Just a nice, even, somewhat euphoric alertness. And it lasted for 8 hours! He hasn't felt such clear, consistent benefits of d-methylphenidate in years. And this was just 5mg!
Can anyone out there explain why this combo would have such an effect?
Since the last post, SWIM has done some further "research" on the subject and the results have been really interesting.
Compated to their opiate and amphetamine cousins, Tramadol and dexmethylphenidate (I'm going to shorten that to d-MPH) are both kind of mild when it comes to the euphoric effects. But taken together, there seems to be a significant increase in both the intensity and duration of the euphoria! This is noticeable for SWIM at doses as low as 50mg Tramadol / 5mg d-MPH.
When increased to 100mg tramadol/ 10mg d-MPH, the stimulant effects are dramatically stronger. Focus, energy, mental clarity, and even motivation are enhanced far beyond what SWIM is used to on 30mg of d-MPH alone.
WARNING! This potentiation of positive effects can apparently shift QUICKLY to an intensification of NEGATIVE effects. SWIM rarely experiences the rapid heart rate, high blood pressure, and anxiety symptoms that he gets from amphetamine— even on 40-50mg/day. But with a combination of 150mg tramadol / 20mg d-MPH (taken as four 5mg generic focalin doses over 3 hours) the stimulant rush got way too intense. Euphoria was NOT improved. Focus and motivation were actually diminished. And heartrate/bp went through the roof! And it lasted WAY too long. I have now idea how long, because SWIM took 1.5mg of klonopin after his heartrate still wasn't slowing down after 30-40 mins.
SWIMs personal conclusion (while assuming all people will react differently to this) is that this combo could potentially be a very useful tool for him to aid focus, positive mood, and energy, but offers very little at even the low end of "recreational" doses.
General conclusion: excercise caution when combining these drugs! Even if swiy knows how they respond to them individually.
Yeah, SWIM always tells people to start with low doses and increase slowly on future doses. In this case he's VERY glad he took his own advice.
And SWIM feels lucky about the first experience, too, because he didn't even consider a possible interaction. He knows that whenever he combines drugs (prescription or otherwise) it's best to research possible contraindications. He didn't do that in this case, but at least he wasn't stupid enough to take his usual full dose of both at once and luckily avoided a trip to the hospital or worse! (THIS TIME).