are CYP2D6 inducers which would account for greater euphoria
from the hydrocodone
Hydrocodone is metabolized into hydromorphone
by the p450 liver enzyme via CYP2D6 therefor the adderall and codeine both of which are CYP2D6 substrates would create a greater conversion of hydrocodone to hydromorphone.
Also the Codeine would be converted into morphine
because of the same concept (Hydrocodone & Adderall CYP2D6 inducers).
has always had greater analgesia/euphoria when he mixed cyp2d6 inducers with hydrocodone & oxycodone
(I.E. dihydro/codeine +/or adderall & hydrocodone, oxycodone & codeine/dihydrocodeine &/or adderall)
This should be pointed out in the opiate