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My understanding is that when Mr Albert Hoffman was making lsd he tried various methods of synthesis. His 25 try was the best method. Ergo LSD-25. Not 100% sure of the accuracy of it but it is what I had read.
A lot. Though they're both 5-HT agonists and hallucinogens, 25I-NBOMe is a phenethylamine, whereas LSD is an ergoline. Both are active in very low doses, but LSD has a much better safety margin than 25I-NBOMe.