Drugs-Forum  
Home Wiki Studies Forum Groups Blog Video Images News
Go Back   Drugs Forum > DRUG-FORUMS > Various drugs not covered by other forums > Nootropics
Mark Forums Read
Register Tags

Notices

Nootropics Smartdrugs, Brain boosters & Cognitive enhancers.

 
Thread Tools
  #1  
Old 18-06-2010, 20:29
supermil supermil is offline
Banned
 
Join Date: 17-06-2010
Male
Posts: 24
supermil needs to UTFSE some more before posting.
Idra-21

IDRA 21, a positive allosteric modulator of the glutamate AMPA receptor, produced a concentration-dependent inhibition of glutamate-induced inactivation of membrane currents in recombinant HEK 293 (human embryonic kidney) cells stably transfected with human GluR1/2 flip receptors. IDRA 21 doubled the charge transfer at a concentration of 70 μM, suggesting that this compound can facilitate excitatory neurotransmission via GluR 1/2 receptors. We next sought to exploit this mechanism of action by examining the drug as a potential cognition-enhancing agent in non-human primates.
Oral administration of IDRA 21 produced a highly significant improvement in the performance of a delayed matching-to-sample (DMTS) task by young adult rhesus monkeys. The pattern of task improvement over the dose range 0.15–10 mg/kg was maintained to 48 hr after the single dose administration. For sessions run after administration of the individualized Best Dose of IDRA 21, task accuracy for Long delay (most difficult) trials was increased by 34% of vehicle. Animals were randomly assigned fixed doses of IDRA 21 to determine whether the positive mnemonic response could be maintained. The repeated doses were separated by 3 days, thus allowing for potential cumulative effects. IDRA 21 produced a gradual increase in task accuracy that was maintained on average above vehicle performance levels over an intermittent dosing schedule during a total period of 3 weeks. A separate group of aged monkeys (>20 y) were, as a group, impaired (during vehicle testing) in DMTS performance efficiency relative to the young cohort. IDRA 21 also improved task accuracy by aged rhesus monkeys over the same dose range, but the responses were not as robust as those exhibited by young animals. Aged subjects also appeared to be more individually sensitive to drug dose, and they exhibited shorter task latencies than did the young group. Despite these differences, when the individualized Best Doses were considered, IDRA 21 produced a robust increase in DMTS accuracy of up to 18% of vehicle for trials associated with Medium delay intervals. For both study groups, no obvious untoward effects of IDRA 21 were noted. These findings support the use of AMPA modulators like IDRA 21 in the treatment of cognitive/memory disorders, including those associated with aging. They also indicate that the drug is associated with long-term effects that could limit dosing regimens to one dose every two or three days. The nature of the protracted mnemonic effects produced by the compound remains to be elucidated.

Post Quality Evaluations:
Please provide references, opposed to just copying and pasting other's information.
This is not useful. Give a source at least. Formating would be nice.
  #2  
Old 22-06-2010, 18:58
Jatelka Jatelka is offline
Psychedelic Shepherdess
 
Join Date: 16-10-2005
38 y/o Female from United Kingdom
Posts: 5,487
Jatelka is a true resource and beyond reputeJatelka is a true resource and beyond reputeJatelka is a true resource and beyond reputeJatelka is a true resource and beyond reputeJatelka is a true resource and beyond reputeJatelka is a true resource and beyond reputeJatelka is a true resource and beyond reputeJatelka is a true resource and beyond reputeJatelka is a true resource and beyond reputeJatelka is a true resource and beyond reputeJatelka is a true resource and beyond repute
Points: 10,860, Level: 15 Points: 10,860, Level: 15 Points: 10,860, Level: 15
Activity: 6.8% Activity: 6.8% Activity: 6.8%
Re: Idra-21

Here is the Pubmed reference:

The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys
Buccafusco JJ, Weiser T, Winter K, Klinder K, Terry AV.
Neuropharmacology. 2004 Jan;46(1):10-22.

Have also uploaded a related paper to the archive here... https://drugs-forum.com/forum/loc...03&linkid=9239

Share this on:

Tags
dosage, pharmacy

Thread Tools


» New Threads
The taste of meth
Last post by wha'happened
59 Replies, 55,854 Views
Takes hours to feel the effects of...
Last post by wha'happened
12 Replies, 1,690 Views
No Euphoria . Just wondering if it...
Last post by wha'happened
2 Replies, 141 Views
Terrible taste when smoking meth.
Last post by wha'happened
9 Replies, 2,505 Views
Suboxone and tramadol
Last post by Marchy87
2 Replies, 318 Views
Weirdest pipe scraping tool you've...
Last post by Milena Hexum
26 Replies, 5,156 Views
Phenibut Effect on Cognitive...
Last post by Adas
1 Replies, 201 Views
MYLAN Brand Fentanyl No Longer...
Last post by TraSea1972
9 Replies, 2,162 Views
Will Meth heads go to heaven?
Last post by Milena Hexum
70 Replies, 3,962 Views
Anyone here keep up with their...
Last post by ceelowks
5 Replies, 312 Views
» New Wiki Articles
DMT

Sitelinks: Information:

All times are GMT +1. The time now is 12:08.


Copyright: SIN Foundation 2003 - 2014, All rights reserved