Drugs-Forum  
Home Wiki Studies Forum Groups Blog Video Images News Chat
Go Back   Drugs Forum > DRUG-FORUMS > Ethnobotanicals
Mark Forums Read
Register Tags

Notices

Ethnobotanicals Psychedelic plants, Iboga, Calea, Blue lotus, Ephedra, Sinicuichi, Betel nut, etc.

 
Thread Tools
  #1  
Old 28-06-2010, 07:44
Porvata Porvata is offline
Titanium Member
 
Join Date: 02-06-2010
Male from USA - Connecticut
Posts: 101
Porvata really adds to the discussion.Porvata really adds to the discussion.Porvata really adds to the discussion.Porvata really adds to the discussion.Porvata really adds to the discussion.Porvata really adds to the discussion.
Points: 785, Level: 4 Points: 785, Level: 4 Points: 785, Level: 4
Activity: 0% Activity: 0% Activity: 0%
Psychotria Umbellata-Opiate, anxiolytic and possible dissociative/psychedelic?

So SWIM was just scouring the internet in an attempt to stumble upon some obscure plants with possible psychoactivity and they found some articles on this plant.

First off, it contains Umbellatine, which seems to have opiate-like activity as well as possible NMDA antagonism.

Quote:
“Interesting analgesic activity has been previously identified in alkaloids isolated from the genus Psychotria (Rubiaceae). We here report the analgesic activity of umbellatine, a new glycoside indole monoterpene alkaloid isolated from Psychotria umbellata. Umbellatine produced a dose-dependent (100-300 mg/kg) analgesic effect, partially reversed by naloxone, in the tail-flick and hot-plate models. These results suggest an analgesic effect at least in part associated with the activation of opioid receptors. In the formalin- and capsaicininduced pain models, umbellatine (100-300 mg/kg) elicited significant and dose-related antinociception. Umbellatine acts synergistically when co-administered with the NMDA antagonist MK-801. These results indicate the involvement of NMDA receptors in the umbellatine mechanism of action. Such a combined mode of action can be of relevance for developing analgesics useful in neurophatic pain.”
Another compound found in this plant, Psychollatine appears to have anxiolytic effects and bind to the 5-HT2a subtype receptor.

Quote:
“Behavioral effects of psychollatine, a new glycoside indole monoterpene alkaloid isolated from Psychotria umbellata, was investigated in models of anxiety, depression, memory, tremor, and sedation related to 5-HT and/or GABA neurotransmission. The GABA antagonist picrotoxin and the 5-HT2 antagonist ritanserin were used to examine the role of GABA and 5-HT2 receptors in psychollatine-induced effects. In the light/dark and hole-board models of anxiety, diazepam (0.75 mg/kg) and psychollatine (7.5 and 15 mg/kg) showed anxiolytic-like effect at doses that do not increase sleeping time nor alter spontaneous locomotor activity. The anxiolytic effect of psychollatine was prevented by prior administration of ritanserin, but not of picrotoxin, indicating that 5-HT2 but not GABA receptors are implicated. In the forced swimming model of depression, psychollatine (3 and 7.5 mg/kg) effects were comparable to the antidepressants imipramine (15 mg/kg) and fluoxetine (20 mg/kg). Psychollatine suppressed oxotremorine-induced tremors in all doses. In the step-down learning paradigm, diazepam (0.85 mg/kg), MK-801 (0.15 mg/kg), and psychollatine 100 mg/kg impaired the acquisition of learning and memory consolidation, without interfering with retrieval. It is concluded that the effects of psychollatine at the central nervous system involve serotonergic 5HT2(A/C) receptors.”
SWIM was under the impression that most 5-HT2a agonists are psychedelic so they wonder if this compound might possibly have psychedelic properties if it does indeed act on those receptors. Needless to say this sounds like a very interesting plant.

Post Quality Reviews:
Very interesting. First bit of info I've ever seen on this plant.

Last edited by Porvata; 28-06-2010 at 07:51. Reason: Removal of incorrect information.
  #2  
Old 17-09-2010, 01:55
phenythylamine phenythylamine is offline
Account Awaiting Email Confirmation.
 
Join Date: 11-09-2010
Male from United States
Posts: 752
phenythylamine must live here.phenythylamine must live here.phenythylamine must live here.phenythylamine must live here.phenythylamine must live here.phenythylamine must live here.phenythylamine must live here.
Points: 1,580, Level: 6 Points: 1,580, Level: 6 Points: 1,580, Level: 6
Activity: 0% Activity: 0% Activity: 0%
Re: Psychotria Umbellata-Opiate, anxiolytic and possible dissociative/psychedelic?

Wow this is really interesting. Has anyone tried this, if so I would love to read an experience report

Share this on:

Tags
opiate, opiates, psychedelia, psychedelic, psychotria

Thread Tools


» New Threads
Confused and worried
Last post by safetyfirst11
20 Replies, 1,144 Views
what is your biggest pet peeve...
Last post by Spunanddelirious
26 Replies, 2,450 Views
Off the Hydrocodone, Cold Turkey,...
Last post by thespeedofdark
4 Replies, 291 Views
If you could tell the person who...
Last post by kellivlem
39 Replies, 4,052 Views
Smoking out of broken meth pipe
Last post by Such is life
7 Replies, 20,619 Views
Your most euphoric combination
Last post by VISTREL
842 Replies, 199,737 Views
Hypothetically, what is the most...
Last post by Smurfettewv
18 Replies, 15,888 Views
Why am I not addicted?
Last post by Waiting For The Fall
10 Replies, 1,097 Views
Yes, it will probably make you...
Last post by Ariky
35 Replies, 5,648 Views
Very unusual withdrawal symptoms,...
Last post by Tangent_String
1 Replies, 60 Views
» New Wiki Articles
GHB

Sitelinks: Information:

All times are GMT +1. The time now is 08:04.


Copyright: SIN Foundation 2003 - 2014, All rights reserved