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  #1  
Old 17-07-2010, 01:13
DextroClonazyCodone DextroClonazyCodone is offline
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Insufflation of antipsychotics for quicker onset

For those of the people who aren't you that take or have taken an antipsychotic, has SWIY ever crushed and insufflated SWIY's medicine to have a quicker onset of symptomatic relief?

Insufflating antipsychotics generally does not yield a higher bioavailability, but it is important to look the oral BA up before trying this. Just a warning.

To SWIM, this method of administration can essentially eliminate the need to ever go to a psychiatric hospital. In the hospital, they would give SWIY an IM injection for quick relief, which SWIY can't do at home. However, one can do this at home to have symptoms relieved in 2 minutes or so (from SWIM's experience). That is a big deal considering many antipsychotics take 45 minutes to work orally.

SWIM discovered this about 6 months ago. He was in a horrible agitated depression and desperately snorted a crushed up 20mg Zyprexa (olanzapine). He felt completely better in 2 minutes and fell asleep in 10 minutes.

Any one else besides SWIM try this?

SWIM would only recommend this for extreme agitation or delusions associated with schizophrenia or bipolar mixed states.
  #2  
Old 18-07-2010, 05:55
Neznam Neznam is offline
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Re: Insufflation of antipsychotics for quicker onset

Swim has tried this with seroquel, but only does it in his most desperate of times. When he was so desperate for relief he even IVed it, both desperation and his needle fixation both played a great deal in this. Few times he would prepare for injection but would throw away as he knows this isnt the safest thing out there. His medication is soon going to be adjusted so hopefuly he wont need to resort to such unsafe measures anymore, although lately its been getting worse and worse.
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Old 22-09-2012, 00:51
Mindless Mindless is offline
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Re: Insufflation of antipsychotics for quicker onset

Intramuscular injections of any antipsychotic drug do not lead to a faster speed of onset or improved bioavailability. They are generally given either as depot injections (which release over a period of 2-4 weeks) or because a patient is not complying with oral medication. Insufflation probably won't work either, the drug would most likely end up being ingested via nasal drip. Intravenous use of antipsychotic medication increases the risk of sudden cardiac death, as well as the host of other problems associated with intravenous use of tablets intended for oral use:

"There is also a higher probability of QT-interval prolongation in patients using any intravenous antipsychotic drug, or any antipsychotic drug or combination of antipsychotic drugs with doses exceeding the recommended maximum. Cases of sudden death have occurred.' (British National Formulary 63 March 2012).

Last edited by Mindless; 24-09-2012 at 13:43. Reason: added quote and source

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antipsychotic, antipsychotics, bioavailability, drugs-forum, insufflate, insufflated, insufflation, olanzapine, quetiapine, seroquel, snorting, snorting drugs, zyprexa

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