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the other day swim who takes 60mg of adderall xr and drinks coffee on a daily basis took 200mg of tramadol at around 4p.m. swim was ok but he wonders if he will be ok if he tool 300mg of tramadol along with the adderall and coffee if he takes them roughly around the same time one morning say around 7 a.m.
chamfan93 added 1 Minutes and 53 Seconds later...
sorry for the double post guys, im new to this sight and messed up typing something
chamfan93 added 2 Minutes and 1 Seconds later...
maybe a mod could delete this one? once again sorry for the double post
Last edited by chamfan93; 24-10-2010 at 21:57.
Reason: Automerged Doublepost
SWIM would say to be really careful combining tramadol and strong stimulants. Tramadol could have some odd interactions with stimulants due to its serotonergic/noradrenergic action. SWIM would keep the amphetamine and tramadol separate.
Dammit SWIM typed up a long post and it didn't go through. To sum it up quickly, don't do that combo because of the risk of seizures.
Some info from a drug interaction website:
MONITOR CLOSELY: The risk of seizures may be increased during coadministration of tramadol with any substance that can reduce the seizure threshold, such as selective serotonin reuptake inhibitors (SSRI antidepressants or anorectics), monoamine oxidase inhibitors, neuroleptic agents, central nervous system stimulants, opioids, tricyclic antidepressants, other tricyclic compounds (e.g., cyclobenzaprine, phenothiazines), carbapenems, cholinergic agents, fluoroquinolones, interferons, chloroquine, mefloquine, lindane, and theophylline. These agents are often individually epileptogenic and may have additive effects when combined. Many of these agents also exhibit CNS- and/or respiratory-depressant effects, which may be enhanced during their concomitant use with tramadol.
MANAGEMENT: Caution is advised if tramadol is administered with any substance that can reduce the seizure threshold, particularly in the elderly and in patients with epilepsy, a history of seizures, or other risk factors for seizures (e.g., head trauma, brain tumor, metabolic disorders, alcohol and drug withdrawal, CNS infections).
SWIY can also do some searches and see where others have made the mistake.
That is a high dose of tramadol regardless of any tolerance. Being a prodrug, tramadol can take up to four hours to come on full effect. This combination, particularly with the doses stated, is not safe enough to recommend attempting.
Absolute no-no. SWIM has combined these 2 before. He is very experienced with each substance by itself, but just 15mg Adderall (IR) and 50mg tramadol taken together made him sick as a dog.
His face was white as a ghost, extreme nausea, vomiting, abnormally fast heart-rate, sweating non-stop, stomach pains, pounding headache, couldn't eat.... and on and on. This lasted about 24 hours + after a single dose if this combo.
Maybe SWIM is just sensitive to this combo, but it was certainly very bad for him and probably would be bad for others too.
There is a real danger of serotonin syndrome from combining these too. Thinking back to SWIM's symptoms when he mixed adderall and tramadol, it could have actually been serotonin syndrome... who knows... but anyway, don't take this combo!
Try mixing some ephedrine with the tramadol (instead of Adderall) -- SWIM never had a problem with that, and the 2 synergize very well. Very pleasant experience. Or, on the other hand, SWIY could try mixing the adderall with another opiate (not tramadol). Just some thoughts.
My pet ferret concurs with previous posters....just to be safe it's probably not a good idea. And really, tramadol tends to give most people that slight speedy-revved up feeling by itself, so taking adderall with it might be a waste.
My pet badger would like to preface the following with that fact that he does not recommend the use of tramadol as a recreational drug due to the high liability for seizures in high doses, and ridiculous addiction potential. However, my pet badger also takes 60mg of adderall xr daily, with a 10mg instant release in the afternoon. At about noon, my pet badger took 200mgs of tramadol while already having consumed the 60mgs of xr at 9am. This is not a good idea because the seizure threshold is lowered when a combination like this is ingested. However, my pet badger became incredibly tired and somnelant and relaxed, slightly euphoric and incredibly comfortable while sitting on a couch. The effects lasted from 2pm till around 7pm, and he fell asleep soon after. He did not experience any ill effects whatsoever, however THIS DOES NOT MEAN THE COMBO IS SAFE. Tramadol and adderall are both metabolized/exhibit their pharmacologic effects differently from person to person. Tramadol is not something to take lightly, just read reports about the withdrawl. Not to mention that seizures are unpredictable and can happen after multiple good experiences. Be safe, and welcome to DF (I'm a newbie myself)