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  #1  
Old 04-11-2010, 02:24
Randomiiza Randomiiza is offline
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Injecting(IV) Seroquel and other Anti-Psychotics

Howdy y'all,

I searched and could not find ANYTHING on this, if I didn't search hard enough, I blame the TFSE.

So swim has been on meds for about 10 months.

Anti-psychotics for 8, Seroquel for 3.

He has developed a tolerance, obviously, where 100mg would make him too drowzy, now 600mg is easily shruggable.

Medically, this is fine, sleep is still normal, schizophrenic symptoms abated, but swim would like to know if injection,whether IV or IM is possible with these substances?

Swim is sober, lol off illegals anyways/and alcohol, but he used to be an avid IM user. Why IM? Because that's what needle he first found.

But he's always been interested in trying IV.

So IVing his seroquel is his only chance, at least for using a psychoactive drug.

And yeh I can imagine the answers...DON'T IV MEDS, FILLERS,BINDERS BLAHA. And STAY AWAY FROM NEEDLES!

But I'd imagine people are going to do this anyway, there should at least be some information on it.

I can say personally, swim will NOT do this without information, but I'm sure there are others who search this site, find nothing, and get hurt.

My only regret is that this thread will give people ideas...


Thanks for the informative replies!

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honest about own use and a valid call for discussion of associated risks
  #2  
Old 04-11-2010, 02:42
Neznam Neznam is offline
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Re: Injecting(IV) Seroquel and other Anti-Psychotics

Well Nez's happy mask has tried previously at IVing seroquel.

This is just his experience, and in no way does he recommend anything....

Having a major needle fixation and IVing pretty much any substance whether illicit or pills he thought it would be 'not a good idea' but 'hey ill give it a try' sort of thing. He has read somewhere that prisoners used to use seroquel + cocaine to mimic the effects of a speedball except they called it a Q-Ball, so of course the addict in him pushed on for this little experiment.

He tried this at least 4 times, as a few times he sort of chickened out due to fact that the preperation looked very questionable to him and common sense kicked in and said 'ehh maybe you shouldnt'. The one time he actually did do it, it was 50mg that he had prepared... the solution was really cloudy and again he was hesitant but he did inject it. At first he just froze expecting this overwhelming sedative effects but nothing happened. Didnt feel anything at all. Not saying 50mg is too small of a dose and that a higher dose needs to be tried... its just what Nez's happy mask did. After some thought about why this failed, he sort of just realized that it was pointless to try again as he could really fuck himself up and if anything was to go wrong he would rather it be Heroin than Seroquel.

He has pretty much given up on the thought of IVing any other pills than Narcotics. Hes not going to bother saying dont do it cause from his own experience, he does it anyway... but if you are really like nez's happy mask... trust him when he says, its a waste of time.

Be careful...
  #3  
Old 04-11-2010, 04:14
catseye catseye is offline
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Re: Injecting(IV) Seroquel and other Anti-Psychotics

^^ please listen to Nez's happy mask!
Seroquel(quetiapine fumarate) is only moderately water soluble - so really not a good choice for injecting (aside from the obvious points the OP made about not IV'ing pills anyway). A quick search on the internet says their bioavailability orally is 100% so there wouldn't be anything gained from altering the ROI effects-wise.
If your friend absolutely still must try, please use a wheel filter at the very least to minimise the binders, etc. entering the blood stream.

Last edited by catseye; 04-11-2010 at 04:16. Reason: clarify comment
  #4  
Old 04-11-2010, 11:44
Canmedaa Canmedaa is offline
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Re: Injecting(IV) Seroquel and other Anti-Psychotics

Haloperidol is the IV anti-psychotic of choice, however no physician in their right mind would prescribe it to a patient who would be self-administering. IV anti-psychotics are for use in the hospital alone, and often only used during crises situations in which a patient has become violent or otherwise unruly. IV Haloperidol is also used as a 'chemical restraint' in some patients.

If one finds that they are expeiriencing tolerance to their medications and wishes to increase the dosage then they are strongly advised to take these concerns to the prescribing physician. Haloperidol is availble for prescription to patients who will be self-administering if the OP would be interested in discussing changing the current anti-psychotic to a different one.

Good Luck,
-CAN

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There is no indication for the use of IV haloperidol in treatment or management of psychosis
  #5  
Old 04-11-2010, 16:43
Randomiiza Randomiiza is offline
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Re: Injecting(IV) Seroquel and other Anti-Psychotics

Swim was previously on Haloperidol, 1mg every four hours.

He still has some. Canmedaa, were you talking about pills or prepared liquid?

And no, swim needs to stress that this tolerance is fine medically, only irksome mentally.

If Seroquel is 100% active orally, would injection feel exactly the same, or would there be some kinda rush?

And I would have expected more experience reports, lol I didn't ask for them, but I didn't think it would be this uncommon. Maybe we just need time.
  #6  
Old 04-11-2010, 16:52
dyingtomorrow dyingtomorrow is offline
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Re: Injecting(IV) Seroquel and other Anti-Psychotics

I can understand trying to satisfy a needle fixation, but I still don't understand why someone would want to inject Seroquel.

SWIM has injected all kinds of drugs, but has to say he doesn't see the point in injecting something that isn't going to do anything, besides destroy your veins and cause health problems with all the filler in the pills. For a greater bioavailability? If that's the case it would be much better to just take more.

I am curious - is it the needle fixation? SWIM would highly recommend injecting something else, something that is definitely injectable, rather than IVing Seroquel. I doubt it is a very common thing, and there is undoubtedly very little information about it. It has a moderate chance of being extremely harmful.
  #7  
Old 04-11-2010, 17:46
Randomiiza Randomiiza is offline
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Re: Injecting(IV) Seroquel and other Anti-Psychotics

Yeh I guess it is lol

Swim just doesn't want to use illegal drugs.

Off topic to ask for suggestions eh

Well, it's pretty obvious...find a new fixation.
  #8  
Old 05-11-2010, 16:31
VyRuZ VyRuZ is offline
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Re: Injecting(IV) Seroquel and other Anti-Psychotics

Regarding SWIYou's tolerance to Seroquel, I think it's only perceived.

SWIM's doctor put SWIM on 800mg Seroquel XR, the max clinical dose, because 600mg didn't feel alright. It actually has a paradoxic effect on SWIM - 300mg & 600mg caused more sleepiness than 800mg, which feels perfect. Doctor also described Seroquel as being paradoxic in effect, with higher doses causing even more energy.

Because SWIM has extremely depressive episodes, 2 or 3 times a week because of external factors, he was also put on Depakine/Valproic Acid, in order to make SWIM's fuse last longer. It worked from the very first damned pill.

Now, I deviated a bit, but what I wanted to say is this: you probably haven't developed a tolerance and you should probably not do the IV thing. Talk to your doctor to go to 800mg, and maybe you too will feel better. If you have any other effects which you feel aren't controlled by Seroquel, talk about adding something else. I'm sure there is a cure for everything!
  #9  
Old 05-11-2010, 16:52
kailey_elise kailey_elise is offline
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Re: Injecting(IV) Seroquel and other Anti-Psychotics

Quote:
Originally Posted by VyRuZ View Post
Regarding SWIYou's tolerance to Seroquel, I think it's only perceived.

SWIM's doctor put SWIM on 800mg Seroquel XR, the max clinical dose, because 600mg didn't feel alright. It actually has a paradoxic effect on SWIM - 300mg & 600mg caused more sleepiness than 800mg, which feels perfect. Doctor also described Seroquel as being paradoxic in effect, with higher doses causing even more energy.
Atypical Antipsychotics are strange drugs indeed! I suppose that's part of the reason for the "atypical" in the name.

This post might help explain why 300mg & 600mg of Seroquel (quetiapine) are more sedating than 800mg. Though the linked post is in a distinctly non-medical-text style, it makes quite a lot of sense.

The linked thread is a good read for anyone, but especially people who are exposed to quetiapine (Seroquel) in some form.

To the OP - more isn't always better, especially when it comes to these medications! The above post can explain it better than I, but if one's looking for a more drowsy effect, they would be wise to add an additional drowsy medication (under doctor's supervision, of course!), rather than attempt injection of antipsychotic medication!

The BEST one could hope for, since quetiapine isn't overly water-soluble, is a suspension; this would be VERY BAD - particles floating around in the bloodstream, with the ability to clog up veins, arteries and/or capillaries, causing tissue death/limb death/overall death, without a rush or even a high to speak of on the way out? YUM, sign me up!

Jokes aside, I suppose the best next step would be for one to discuss the continued needle fixation with someone (therapist? 12-step program sponsor?) and try to work through it. Needle fixation isn't fun. (I realize I'm stating the obvious there!)

Good work for your buddy there, it's not easy staying away from alcohol & the illegals, no matter what reason it's being done for! *grin*

All the best.

~Kailey

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good reply on possibity of cardivascular occlusions
  #10  
Old 05-11-2010, 17:17
Randomiiza Randomiiza is offline
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Re: Injecting(IV) Seroquel and other Anti-Psychotics

Very interesting...well the next time Swim sees his doctor, this will be brought up.
  #11  
Old 05-11-2010, 19:02
SWIMJIM SWIMJIM is offline
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Re: Injecting(IV) Seroquel and other Anti-Psychotics

*gets tardive diskinesia just thinking about this* No way.
  #12  
Old 29-09-2012, 02:00
Mindless Mindless is offline
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Re: Injecting(IV) Seroquel and other Anti-Psychotics

Another reason to avoid intravenous use of antipsychotics is this:

"There is also a higher probability of QT-interval prolongation in patients using any intravenous antipsychotic drug, or any antipsychotic drug or combination of antipsychotic drugs with doses exceeding the recommended maximum. Cases of sudden death have occurred." (British National Formulary 63 March 2012).

An increased probability of sudden cardiac death for no real recreational gain. Even if quetiapine had recreational value this would be a very risky route of administration.

Last edited by Mindless; 29-09-2012 at 02:04. Reason: new sentence
  #13  
Old 29-09-2012, 02:44
sikk66 sikk66 is offline
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Re: Injecting(IV) Seroquel and other Anti-Psychotics

My friend's pet penguin has done this. Several times. In doses ranging anywhere from 50mg to 500mg. He did use a wheel filter for these experiments. He wanted me to let you know that it is a complete waste of time. He had no effects whatsoever from the IV Seroquel.
Zero reward for way too much risk.

Just thought I'd pass this story along to you.
Please be safe

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relevant and informative post
  #14  
Old 27-10-2012, 03:10
medicated_life medicated_life is offline
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Re: Injecting(IV) Seroquel and other Anti-Psychotics

Injecting Seroquel is pointless, it's not very water soluable and provides no rush/euphoria whatsoever from injecting. THIS MEDICATION HAS NO RECREATIONAL VALUE. I don't know why people think it does...

And injecting seroquel is dangerous becuase of the binders/fillers in the pills, just like injecting most psychiactric medications. Very very bad idea.
  #15  
Old 27-11-2012, 06:27
jermeypayne420 jermeypayne420 is offline
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Re: Injecting(IV) Seroquel and other Anti-Psychotics

Bangin' seroquil was used as a last resort to fall asleep faster than oral injestion while dopesick and tryin to kick heroin. 400mg's slowly dissolved in water for around 10 minutes. Felt it a little, but the junkie wasnt subdued.

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use as described in this post may have fatal consequences
incredibly dangerous advice.

Last edited by Phenoxide; 22-07-2013 at 17:15.
  #16  
Old 30-11-2012, 18:40
Mindless Mindless is offline
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Re: Injecting(IV) Seroquel and other Anti-Psychotics

The oral dose proposed in the above post would present an increased risk of adverse effects. It is worth noting that the total maximum daily dose is 800 mg, in two doses. Some of the more alarming risks that accompany doses in excess of this maximum are cardiovascular side-effects such as tachycardia, arrhythmias and hypotension. Seizures are another possibility, as are Stevens-Johnson syndrome and rhabdomyolysis (the release of muscle fibres into the bloodstream) which may result in kidney damage.

QT-interval prolongation is more likely where maximum dose is exceeded. There have been cases of sudden cardiac death associated with QT-interval prolongation arising from antipsychotic use. I'm aware that I'm repeating information I gave earlier in this thread, I just want to make it clear that there are substantial increases in risk associated with excessive oral doses as well. This applies to antipsychotic drugs in general.

It is important that there is a controlled titration of dose with quetiapine. For example 25 mg twice daily is the maximum dose on day one, 50 mg on day two and so on, increasing in increments. Suicidal ideation may occur with quetiapine use, especially on initiation of use. Please only take this drug as prescribed and definitely not at single doses of 800-1000 mg.

Source: British National Formulary November 2012.

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good specific information

Last edited by Mindless; 01-12-2012 at 00:31. Reason: format and new comment
  #17  
Old 14-01-2013, 20:10
Psychonauticunt Psychonauticunt is offline
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Re: Injecting(IV) Seroquel and other Anti-Psychotics

Whatever neuroleptic you choose, make sure you research its solubility, and whether or not it is suitable for injection in general.

I have once shot up an antipsychotic, Nozinan (methotrimeprazine/levomepromazine). I had accidentally taken way too much amphetamines and had already been up two nights, so I could feel the shadow people gathering. Nozinan is absorbed very slowly when taken orally so I injected it. I filtered a tablet, but it is also supplied as injection ampoules so I figured it was a viable way of taking it.

Worked well; within 15 minutes I was sleeping like a baby and the shadow people were told the party was over and all left.
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Old 22-10-2015, 16:27
SideAffektz SideAffektz is offline
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Re: Injecting(IV) Seroquel and other Anti-Psychotics

i know this is about iv roi,and sorry to bring up a thread from ages ago, but it be smoked? chased on foil or through a pipe..? just curious if anyone has tried it.. saw the question missed on bluelight no one really answered,, i figured if theres talk about injecting it then there should be the "smoking it" warning too.

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off topic, there is more than enough information in this forum for you to read, there is no need to dig up an old thread that has nothing to do with this question.
  #19  
Old 24-10-2015, 11:19
Mindless Mindless is offline
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Re: Injecting(IV) Seroquel and other Anti-Psychotics

Psychonauticunt, although it seems reasonable to research the solubilty of an antipsychotic, this does not address the (posssibly) unkown fillers and binders. These may or may not be water soluble. What steps do you take regarding filtration?

Where a professionally formulated antipsychotic is available in injectable vials, this does not imply that tablets or capsules are safe to use intravenously.

Antipsychotics are not the drug of choice when one has over-indulged in amphetamines. In a clinical setting benzodiazepines are favoured, these would be a less risky alternative at home as well. The risks of serious adverse reactions are fewer and generally less potentially life-threatening. Benzodiazepines are easiest to use orally, generally with good effect.

Last edited by Mindless; 26-10-2015 at 14:34.
  #20  
Old 03-01-2016, 04:15
cjh1221cjh cjh1221cjh is offline
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Re: Injecting(IV) Seroquel and other Anti-Psychotics

Exactly correct that less is more sedating but that it because in smaller doses, ie. 100 mg. or less, the anti-psychotic properties are diminished greatly and Quintiapine Fumarate, (Seroquel) acts as an anti-histamine (think Benadryl but waaaay stronger) more than anything else. In doses above 100 mg. and increasingly so as mg. increase, the anti-psychotic properties increase and the anti-histamine and sedation qualities decrease. By the time you reach 100 mg. +, the sedation has stopped for the most part and will begin to have the opposite affect (effect?...I always mix up the two haha). The higher the dose after 100 mg., the more stimulating and anti-psychotic qualities it has. You also can, and will, develop a tolerance to it. To stop this, simply take a few days to a week off when it stops working (for sedation). Your tolerance will return to baseline and at such low doses, titration is a non-issue. Actually, you should titrate up, and down in 25 mg. increments, but for doses of 100 mg. or less, it is really a non-issue.

As far as IV goes, it is really an over-the-top ROA to be honest, and just silly. The oral bioavailability of Seroquel is close to 100%. There is no way to get a higher amount into your system. IV administration would have the same BA, assuming you could actually get ALL of the active ingredients out of the tablet. Because it is only partially soluable in water, you are essentially turning, for example, (and in no way are these numbers correct, just using them for an abstract example), a 100 mg. tablet into less than that. If I had to guess, I would say that you could extract maybe 60% of the active ingredient. That would mean you are turning a 100 mg. tablet into a 60 mg. dose AND adding the risks that are involved with IV administration. Anything from bacteria, abscess, foreign matter, vein necrosis, particles of fillers/binders lodging in lungs, and injection of inactive ingredients, to name a few. So the actual dose (estimated) of a 100 mg. tablet would actually be 100 mg. entering the blood stream via oral administration vs. about 60 mg. administered via IV. I really hate to be the bearer of bad news or come off sounding condescending, but I hope I have opened your eyes to the stupidity of IVing Seroquel, and many other drugs for that matter.
I also would like to apologize in advance for reviving such an old thread, but, in the interest of harm reduction and hoping to supply anyone wondering the same thing that runs across this thread in the future with the most correct and safest information available, I felt it was a good idea.

In summation, don't do it. It's dumb. If you are looking for the most effective sedation from Seroquel, orally administer around 75 mg. If you are looking for the anti-psychotic effects (affects? Lol), then ask your doctor about it and go ahead and climb into the 100+mg. ranges. Please don't do more than 800 mg./day split into at least two separate doses. It's just not safe or worth it, as mentioned above.
Thanks for reading my little rant. Please play safe!

Edit*

For the love of God....KNOW WHAT YOU ARE PUTTING INTO YOUR BODIES PEOPLE!!!!! Regardless of ROA or type of medication, please research it at least a little bit before choosing to put it inside yourself! It's just common sense!

Edit*

Quintiapine Fumarate, (Seroquel) is a very abnormal anti-psychotic. Most other anti-psychotics/anti-histamines do not work the same way. I can only think of one other and I cannot remember it's name as, if I'm not mistaken, it is no longer even legal to prescribe in the US or most of Europe. I do know that it is/was very similar molecularly to Seroquel, therefore it makes sense that it would act similarly. I doubt it is even manufactured anymore to be honest.

PLAY SAFE!

Last edited by cjh1221cjh; 03-01-2016 at 04:42. Reason: Forgot to add something...if you can believe there could be more haha!

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antipsychotics and sudden cardiac death, bad ideas, intravenous injection, qt interval prolongation, risks of iv antipsychotic use

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