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Hello I had a dream about my friend having a dream where he was watching a movie the main character was a guy named SWIM in this movie SWIM asked his friends this question. how much do you need to snort to OD.SWIM knew he was not going to OD, but SWIM was just worried and wanted to know for the future. Before the movie SWIM said thank you to every that helps him gain the knowledge that he wants to know. Then my dream ended.
While this doesn't list the dose for humans, it does, Mr. Hamster believes states that the LD50 for rats and mice is between 40-50mg/kg when injected IV.
Insufflation would be fairly close to IV, but a bit less efficient depending on the sinus conditions. Both routes bypass first pass metabolism by the liver.
A responsible hamster would never want to try to get anywhere near the LD50 of any substance.
However, the normal dose for the IR formulation taken orally is typically 10-20mg.
Given this, one could say that 10-20mg insufflated might be safe, but every hamster and chinchilla are different. So the best advice is to start small if taking medications in a nonprescribed manner and always remember one can always take more, but can never untake what's been taken.
Also, take a look at this thread, this is a subject which has been discussed before:
LD50's aside, SWIM's poo flinging monkey in a dream (SPFMIAD) said that the amount SWIY's nose is clogged has a whole hell lot more to do with bioavalibility. in any case, ritalin psychosis, which SWIY seems to have, according to SPFMIAD, wears off not as quick as SWIY would hope, but seeing as this post was written about week ago, please allow SWIY to look retrospectively on the whole experience and evaluate whether his/her experience was really worth the deafening paranoia. if SWIY does some soul searching, this psychotic episode must have been a pretty powerful lesson. HIGH DOSES OF METHYLPHENIDATE CAUSES PSYCHOSIS!!! (not going generally 'off the farm' but definitely paranoid thoughts).
My rabbit performed a test over Thanksgiving break and didn't take her methylphenidate because she didn't have work or school responsibilities and her system kind of corrected itself.
Now that my rabbit is taking Concerta a few days a week again it is irregular again, to the point where she may have to look for another medication all together It however, isn't as severe as when she would take Concerta in the morning and Ritalin at 4pm.