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  #1  
Old 28-12-2010, 17:19
cheesefan cheesefan is offline
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Kadian 20 mg questions

Hello. SWIM recently came across kadian 20 mg pills and was looking to use them recreationally. The person who gave them to SWIM recommended he crush up some of the beads and take orally. SWIM has some experience with opiates, but takes them rarely so does not have much of a tolerance.

SWIM is curious about recreational dosages for someone like him. He weighs 220 lbs or 99kg. He recently took 5, 5mg Hydrocodone with a nice but not-too-intense high.
SWIM is prone to sinus infections so does not want to insufflate.

SWIM is also curious about side effects and how common they are. SWIM read that common side effects include constipation, nausea, dry mouth, sweating. SWIM would appreciate any opinions or experiences with side effects.

SWIM would really appreciate any information.

Thanks
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Old 28-12-2010, 18:26
kailey_elise kailey_elise is offline
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Re: Kadian 20 mg questions

Make certain to do some more research in this (the Morphine) forum.

Morphine isn't very active orally - you lose a LOT of it to first-pass metabolism in the liver when it's taken orally. IIRC, oral morphine dose is 1-to-1 with oral hydrocodone; meaning that if one usually takes 25mg of hydrocodone to get relief, one would need 25mg of morphine orally to obtain the same level of relief. Keep in mind that the extended release format of Kadian changes that somewhat (in that the suggestion to crush the beads first would be a good one).

Morphine is FAAAAAR more bioavailable (meaning it works MUCH better) by pretty much ANY method other than oral - half the oral amount could be used, say, rectally, and would lead to much more relief than the oral dose. Nasal administration is also more effective. This is because rectal & nasal admin bypass much of the first-pass metabolism effect of the liver. Rectally, one could crush the beads, mix with a small amount of water, suck the solution into a syringe without a needle or (even better) with an oral/liquid medicine syringe, lube slightly (olive oil or hand lotion works in a pinch), insert in anus & release liquid.

The method above could be recommended for every opioid, but it is ESPECIALLY recommended for administration of morphine; it sounds very strange & awkward, but really makes THAT much of a difference over oral admin. The only way one could get a better kick out of morphine is via IV (which is not recommended). There are many who might even say that morphine orally is a waste of the drug.

Side effects are generally the same as any other opioid; if one has experienced hydrocodone, the side effects are about the same.

Do some more research, be safe & good luck!

~Kailey
  #3  
Old 28-12-2010, 21:19
cheesefan cheesefan is offline
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Re: Kadian 20 mg questions

Thanks for your response. SWIM knows morphine (as well as many other drugs) are more bioavailable when used rectally, but SWIM has been reading that orally more efficient than insufflation. SWIM read a couple of threads here and read in other sources that orally its bioavailability is 25-30%, whereas insufflation is around 15-20%.

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drug, drugs, drugs forum, insufflation, kadian, morphine, morphine modes of administration, n2o

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