Originally Posted by Ghetto_Chem
Swims friend has also dissolved his yayo in a saline nose spray bottle. It worked great but this was winter, and it only lasted three days so who knows about any extended times in solution.
Mr. Hamster used to do this all the time in saline solution and ethanol
. He never had a problem when he did such things.
He's requested a research paper on this be added to the archive. So, the jury is out until we can see some evidence from some controlled experiments.
Not that the hamster is doubting, but he'd like to see it backed up a bit more with an experimental study with controls and empirical evidence.
The paper is:
STABILITY OF COCAINE IN AQUEOUS SOLUTION
- John B. Murray,
- Hasan I. Al-Shora
Article first published online: 28 JUN 2008
Originally Posted by Ghetto_Chem
So if cocaine
in the body what is to say its not going to be created in the alcohol solution? Cocaine is best to stay in its crystal form.
Cocaethelyne is a product of an enzymatic methyl transcripterase which performs tranesterfication in vivo in the liver. Ethanol must be present in the body when this occurs. It's not something which spontaneously occurs in solution.
Medical cocaine solutions are 5-10% cocaine in alcohol. They last a very long time.
Agreed, it's best to stay in crystalline form as there would be a possibility of a reaction between any number of things which might be mixed in as adulterants. The only time one might want to use a solvent or reagent would be for cleaning or purification, then back into a solid.
wanderer added 726 Minutes and 8 Seconds later and the research is in...
While the research paper only examined cocaine solution in an opthalmic preparation, it does highlight a couple of things. It confirms that cocaine does indeed degrade in water solution. This is due to several things, the pH of the solution and the storage temperature. This was also done with distilled, sterilized water.
From the research paper: STABILITY OF COCAINE IN AQUEOUS SOLUTION
(Please refer to the document for the tables indicated in the text.)
Originally Posted by STABILITY OF COCAINE IN AQUEOUS SOLUTION
The main application of the work has been the determination of the stability of Cocaine Eye Drops BPC and a comparison with buffered cocaine solutions. The results are shown in Tables 3 and 4.
Cocaine Eye Drops BPC are unbuffered sterile solutions, the stability of which after autoclaving or steaming in 5-ml glass ampoules is shown in Table 3.
At pH 6.8 in Table 4 and 25°C the predicted t10% was 24.5 h + 1 .l, -1.06 (P = 0.95) and the experimental f was in the range 23.4-22.7 h. However, at 5°C the predicted and experimental t10% was not in close agreement, the difference being possibly due to the difficulty in control of the storage temperature at 5°C. At pH 5.0 good agreement was found at 25°C between the experimental and predicted t10%. The predicted t10% was 102.1 + 39.4/- 30.0 days and the found t10% was 87.0 f 1.9 days. Storage at 5°C for pH 5.0 showed only a 4% loss after 6 months.
Cocaine eye drops buffered at pH 2.2 were very stable losing only 5% after 6 months storage at 25°C. Although cocaine hydrochloride solutions buffered at pH 5 and at pH 2.2 exhibit good stability they may cause irritation before the eye can adjust the pH to 7.4. As cocaine is absorbed and acts as the free base, and with a pKa of 8.6 the quicker the pH increases the better for the anaesthetic properties of the solution.
In conclusion we consider that the formulation and methods of preparation recommended by the BPC 1973 are acceptable in respect of the chemical stability of the alkaloid
: the assay outlined above should replace the BPC assay and the eye drops should be stored
at 5°C with a time limit of 6 months.
So the hamster concedes that there is degradation, but it doesn't appear to be as rapid as some critters believe, though environmental factors are a consideration. The faster degradation in water shown in anecdotal evidence could be due to several factors, the pH of the water, storage temperature, and any potential reactants in the water in the case of nondistilled unsterilized water. Ultimately, water is not that good a long term storage medium, but it's not altogether terrible if it's done under the right conditions, and a six month shelf-life is indicated as it only loses 10% concentration over that period in a solution with pH of 5.5. Although, the higher the pH, the less degradation occurs.
Now, the hamster hasn't found anything on storage in alcohol which would be the case for a topical solution, or for internal use in anesthetizing and/or cauterizing the sinuses or other topical applications where alcohol concentration is not as great a factor as it would be in the case of an opthalmic application such as a surgical procedure. The hamster would like to find some experimental data on pure alcohol as a medium and see what its conclusions are.
The hamster hopes that settles the debate regarding an aqueous solution, and helps to confirm SWIGhetto_Chem's hypothesis based on his critter's experimental observations. The hamster would also like to thank SWIGhetto_Chem's critter for bringing this subject to light and helping to explore it in a bit more detail.