I've done/do it both ways. One of the effects of Tramadol
, for me at least, is that it simply kills my appetite. As said above, when taken on an empty stomach the effects come up faster, but stomach upset is always possible. I've found that laying down for 10 to 15 minutes will usually take care of this. There were times, during my higher dosing day's, that I would actually throw up, but it would come up empty as there was nothing in my stomach to throw-up. Afterwards it would settle down with no more problems.
As I mentioned above, Tramadol really takes my appetite away. I usually take 2 dose's a day, and if I take the second dose prior to eating supper, supper may sit on the stove for a few hours before I feel like I can eat it. This sometimes make's for a very dried out, overdone, supper!