First of all, and I don't mean to chide, but a quick google search of "rectal administration of acetaminophen
" will lead you mostly to abstracts, two of which are:
Now, even though both of these studies were done with children, we adults can garner a bit of insight. Without much knowledge on the matter, those studies at least say to me, "If acetaminophen can be, has been, and is given to children rectally at an equivalent dose for their age and size, acetaminophen can, probably, be safely taken rectally by an adult in moderation of both dose and frequency." If you were only taking 650mg of APAP
that way (which is only slightly more than a single Tylenol tablet) and didn't do it often, I would guess it's not an issue. Keyword: "guess," not "guarantee," and certainly not "condone."
Most of us around here are aware of the dangers of APAP and the liver, though I won't pretend to know a damn thing about how the liver gets involved when you plug. The short story is, however, the less APAP you can take the better, so if you were able to perform a fairly successful CWE on 2 5-325 tablets and have a good time, then that's just less you have to worry about.
As for "plugging
takes 1/10 oral," that is absolutely untrue. But it is only untrue because it's a blanket statement. For drugs
, which have an extremely low oral bioavailability, I could easily see that being the case. Oxycodone
happens to have a very high oral bioavailability. I've seen the number close to 90%, which means IVing oxycodone would only get you about 10% (give or take) more of the medication at peak plasma levels. The time it takes to reach
peak plasma levels is phenomenally less when one IVs and dose must be altered accordingly. I am not an IV drug
user, and I'm not suggesting it here... but my point is plugging lies in something a gray area in between oral use and an IM injection, depending on the drug. You have to understand there hasn't exactly been a lot of research on drug abusers who prefer rectal administration.
I would say, because of the high oral availability of oxycodone, you are about correct that perhaps a half an oral dose is a good place to start for plugging, since it will come on slightly quicker and last slightly less long. As for morphine
, they're two totally different ballgames (from both each other and oxycodone) so I would suggest making a post in the forums for those drugs if it ever becomes a possibility that you will plug them in the near future.
As for your final question, CNS depressants
safe to mix.
Hope that helps!