says that they wait about 2-3 hours, however it depends on each person's metabolism. Considering that hydrocodone
is processed through the stomach and liver before it does you any good, SWIM says that after eating a high calorie, high fat meal such as a burger and fries, the liver will be working overtime, and SWIY should wait as long as possible (closer to 4 hours) before taking the hydrocodone, especially if the NSAID it's combined with is acetaminophen
, which easily causes hepatoxicity at high doses and can harm the liver more if it's already fatigued after a meal such as that. That's SWIM's two cents of advice...